Hippocampal Development: Structure, Function and Implications

Lee, Joshua K.; Johnson, Elliott G.; Ghetti, Simona

doi:10.1007/978-3-319-50406-3_6

Cited by 29 publications

(24 citation statements)

References 136 publications

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“…The hippocampus does however appear to be involved in a broad specter of cognitive functions and behaviors that may also include e.g. spatial navigation, emotional behavior, stress regulation, imagination and prediction ( Aribisala et al, 2014 ; Lee et al, 2017 ; Mullally and Maguire, 2014 ; Rubin et al, 2014 ). Intriguingly, in a large study of older adults, general intelligence was found to be associated with several measures of tissue microstructure in the hippocampus, which were derived from diffusion tensor imaging, magnetization transfer and relaxometry, but not with whole hippocampus volume ( Aribisala et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

“…Further, a recent study showed greater variance in males than females for several brain volumes including the hippocampus ( Wierenga et al, 2018a ), and future studies should investigate whether such variability differences are general or specific for distinct hippocampal subregion volumes and development. Next, future developmental studies should integrate subregion segmentation in the transverse plane and along the longitudinal axis of the hippocampus ( Lee et al, 2017 ). Finally, future studies could also investigate development of hippocampal-cortical networks at the level of specific hippocampal subregions, e.g.…”

Section: Discussionmentioning

confidence: 99%

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Longitudinal development of hippocampal subregions from childhood to adulthood

Tamnes

Bos

Kamp

et al. 2018

Developmental Cognitive Neuroscience

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HighlightsHippocampal subregions develop in differential ways from childhood to adulthood.Subiculum, CA1, ML and fimbria showed nonlinear trajectories with initial increases.Parasubiculum, presubiculum, CA2/3, CA4 and GC-DG showed linear volume decreases.There were no sex differences in hippocampal subregion development.General cognitive ability associated with CA2/3 and CA4 volumes and ML development.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Longitudinal development of hippocampal subregions from childhood to adulthood

Tamnes

Bos

Kamp

et al. 2018

Developmental Cognitive Neuroscience

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…Further, a recent study showed greater variance in males than females for several brain volumes including the hippocampus (Wierenga et al, in press), and future studies should investigate whether such variability differences are general or specific for distinct hippocampal subregion volumes and development. Next, future developmental studies should integrate subregion segmentation in the transverse plane and along the longitudinal axis of the hippocampus (Lee et al, 2017). Finally, future studies could also investigate development of hippocampal-cortical networks at the level of specific hippocampal subregions, e.g.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal development of hippocampal subregions from childhood to adulthood

Tamnes

Bos

Kamp

et al. 2017

Preprint

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Detailed descriptions of the development of the hippocampus promise to shed light on the neural foundation of development of memory and other cognitive functions, as well as the emergence of major mental disorders. Hippocampus is a heterogeneous structure with a well characterized internal complexity, but development of its distinct subregions in humans has remained poorly described. We analyzed magnetic resonance imaging (MRI) data from a large longitudinal sample (270 participants, 678 scans) using an automated segmentation tool and mixed models to delineate the development of hippocampal subregion volumes from childhood to adulthood. We also examined sex differences in subregion volumes and their development, and associations between hippocampal subregions and general cognitive ability. Nonlinear developmental trajectories with early volume increases were observed for subiculum, cornu ammonis (CA) 1, molecular layer (ML) and fimbria. In contrast, parasubiculum, presubiculum, CA2/3, CA4 and the granule cell layer of the dentate gyrus (GC-DG) showed linear volume decreases. No sex differences were found in hippocampal subregion development. Finally, general cognitive ability was positively associated with CA2/3 and CA4 volumes, as well as with ML development. In conclusion, hippocampal subregions appear to develop in diversified ways across adolescence, and specific subregions may link to general cognitive level.HighlightsHippocampal subregions develop in differential ways from childhood to adulthoodSubiculum, CA1, ML and fimbria showed nonlinear trajectories with initial increasesParasubiculum, presubiculum, CA2/3, CA4 and GC-DG showed linear volume decreasesThere were no sex differences in hippocampal subregion developmentGeneral cognitive ability associated with CA2/3 and CA4 volumes and ML development

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“…Thus, initial work suggested that memory development during middle childhood and adolescence is mainly driven by maturation of the prefrontal cortex (see [1] for a review), supported by converging structural [19,42–44] as well as functional neuroimaging [45,46] evidence. However, this view has been challenged when improvements in magnetic resonance imaging (MRI) allowed for mapping developmental trajectories of human hippocampus in vivo with increasing precision [see 47 for a recent review on MRI imaging of hippocampal development]. As a result, some studies reported data suggesting age-related changes within the hippocampal circuitry that extend beyond childhood and potentially even adolescence [41,48].…”

Section: Human Hippocampal Maturation Continues Into Adolescencementioning

confidence: 99%

Hippocampal Maturation Drives Memory from Generalization to Specificity

Keresztes

Ngo

Lindenberger

et al. 2018

Trends in Cognitive Sciences

129

119

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During early ontogeny, the rapid and cumulative acquisition of world knowledge contrasts with slower improvements in the ability to lay down detailed and long-lasting episodic memories. This emphasis on generalization at the expense of specificity persists well into middle childhood and possibly into adolescence. During this period, recognizing regularities, forming stable representations of recurring episodes, predicting the structure of future events, and building up semantic knowledge may be prioritized over remembering specific episodes. We highlight recent behavioral and neuroimaging evidence suggesting that maturational differences among subfields within the hippocampus contribute to the developmental lead-lag relation between generalization and specificity, and lay out future research directions.

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Hippocampal Development: Structure, Function and Implications

Cited by 29 publications

References 136 publications

Longitudinal development of hippocampal subregions from childhood to adulthood

Longitudinal development of hippocampal subregions from childhood to adulthood

Longitudinal development of hippocampal subregions from childhood to adulthood

Hippocampal Maturation Drives Memory from Generalization to Specificity

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