Hippocampal distribution of parvalbumin neurons in female and male rats submitted to the same volume and intensity of aerobic exercise

Placencia, Eduardo Varejão Díaz; Serra, Fernando Tadeu; Henrique, Jéssica Salles; Arida, Ricardo Mário; Silva, Sérgio Gomes da

doi:10.1016/j.neulet.2018.10.028

Cited by 6 publications

(2 citation statements)

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“…Under control conditions it appears female C57Bl/6J mice have slightly more parvalbumin neurons [37], but levels are reportedly similar in both sexes in the hilus of the hippocampus [38]. The increase in paravalbumin levels in females following rCBI is unknown, but exercise is known to increase paravalbumin neuron number in the hippocampus and female mice in general, and as observed here after TBI, are more active [39].…”

Section: Discussionmentioning

confidence: 97%

Sex differences in cued fear responses and parvalbumin cell density in the hippocampus following repetitive concussive brain injuries in C57BL/6J mice

et al. 2019

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There is strong evidence to suggest a link between repeated head trauma and cognitive and emotional disorders, and Repetitive concussive brain injuries (rCBI) may also be a risk factor for depression and anxiety disorders. Animal models of brain injury afford the opportunity for controlled study of the effects of injury on functional outcomes. In this study, male and cycling female C57BL/6J mice sustained rCBI (3x) at 24-hr intervals and were tested in a context and cued fear conditioning paradigm, open field (OF), elevated zero maze and tail suspension test. All mice with rCBI showed less freezing behavior than sham control mice during the fear conditioning context test. Injured male, but not female mice also froze less in response to the auditory cue (tone). Injured mice were hyperactive in an OF environment and spent more time in the open quadrants of the elevated zero maze, suggesting decreased anxiety, but there were no differences between injured mice and sham-controls in depressive-like activity on the tail suspension test. Pathologically, injured mice showed increased astrogliosis in the injured cortex and white matter tracts (optic tracts and corpus callosum). There were no changes in the number of parvalbumin-positive interneurons in the cortex or amygdala, but injured male mice had fewer parvalbumin-positive neurons in the hippocampus. Parvalbumin-reactive interneurons of the hippocampus have been previously demonstrated to be involved in hippocampal-cortical interactions required for memory consolidation, and it is possible memory changes in the fear-conditioning paradigm following rCBI are the result of more subtle imbalances in excitation and inhibition both within the amygdala and hippocampus, and between more widespread brain regions that are injured following a diffuse brain injury.

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Section: Discussionmentioning

confidence: 97%

Sex differences in cued fear responses and parvalbumin cell density in the hippocampus following repetitive concussive brain injuries in C57BL/6J mice

et al. 2019

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“…These alterations may be reversed with a Complete EE (Montes et al, 2017; Paez-Martinez et al, 2013), but more research is necessary to understand the mechanisms underlying the benefits of exercise and social interaction on memory. Plausible mechanisms may involve the role of brain-derived neurotrophic factor, which increases in the hippocampus of mice after using running wheels and supports the growth, maintenance, and regeneration of neurons in this region (Varejaõ, Serra, Salles, Arida, & da Silva, 2018).…”

Section: Discussionmentioning

confidence: 99%

Physical exercise and social interaction in complex environments reverse memory deficits induced by inhalants

2019

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Inhalant abuse is a global issue with major behavioral, cognitive, and social consequences. Some effects of this abuse are observed in memory deficits, but the organism–environment interactions are poorly understood. We propose that studying environmental enrichment (EE) in animal models allows the elucidation of adaptive behavior mechanisms to face harmful effects, as well as plausible translational interventions; however, the effects of the different elements that comprise the complexity of EE must be determined. In this work, we measured the effects of housing under five environments for 4 weeks on memory impairments induced by the repeated administration of toluene in mice (4000 ppm, 30 min/day for 4 weeks). Recognition memory was recovered after housing in a complete enriched environment involving voluntary exercise with running wheels, cognitive stimulation with objects to explore, and social interaction. However, enrichment with only voluntary exercise in social conditions produced a significant memory recovery. In addition, EE in isolation showed fewer beneficial effects, while cognitive stimulation, even under social conditions, did not reverse the memory impairment by itself. We argue that physical exercise and social interaction could derive in cognitive enhancement and be used to advise on psychosocial interventions.

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Exercise ameliorates post-stroke depression by inhibiting PTEN elevation-mediated upregulation of TLR4/NF-κB/NLRP3 signaling in mice

Wang

et al. 2020

Brain Research

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Hippocampal distribution of parvalbumin neurons in female and male rats submitted to the same volume and intensity of aerobic exercise

Cited by 6 publications

References 35 publications

Sex differences in cued fear responses and parvalbumin cell density in the hippocampus following repetitive concussive brain injuries in C57BL/6J mice

Sex differences in cued fear responses and parvalbumin cell density in the hippocampus following repetitive concussive brain injuries in C57BL/6J mice

Physical exercise and social interaction in complex environments reverse memory deficits induced by inhalants

Exercise ameliorates post-stroke depression by inhibiting PTEN elevation-mediated upregulation of TLR4/NF-κB/NLRP3 signaling in mice

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