1992
DOI: 10.1016/0306-4522(92)90379-g
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Hippocampal excitatory amino acid receptors in elderly, normal individuals and those with Alzheimer's disease: Non-N-methyl-d-aspartate receptors

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Cited by 49 publications
(16 citation statements)
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“…These data are consistent with the results of a number of autoradiographic studies (Greenamyre et al, 1987;Jansen et al, 1990;Penney et al, 1990;Geddes et al, 1992) and with the data of Hyman et al (19941, who also observed intense GluRl immunolabeling within the molecular layer of the dentate gyrus. In our study, as well as in Hyman's investigation (19941, it was demonstrated that a considerable degree of the immunolabeling within the molecular layer could be attributed to GluR1-positive dendrites originating from neurons in the granule cell layer.…”
Section: Discussionsupporting
confidence: 94%
See 1 more Smart Citation
“…These data are consistent with the results of a number of autoradiographic studies (Greenamyre et al, 1987;Jansen et al, 1990;Penney et al, 1990;Geddes et al, 1992) and with the data of Hyman et al (19941, who also observed intense GluRl immunolabeling within the molecular layer of the dentate gyrus. In our study, as well as in Hyman's investigation (19941, it was demonstrated that a considerable degree of the immunolabeling within the molecular layer could be attributed to GluR1-positive dendrites originating from neurons in the granule cell layer.…”
Section: Discussionsupporting
confidence: 94%
“…Interestingly, our data for the distribution of GluRl and GluR213, as well as those of Hyman et al (19941, disagree with previous studies demonstrating that r3H1AMPA binding sites are most dense within the CA1 field (Dewar et al, 1991;Geddes et al, 1992). Although the reasons for these various findings remain to be uncovered, there are a number of functional and mechanical variables that might affect the binding of a ligand to its receptor andlor the binding of an antibody to its respective antigen.…”
Section: Discussioncontrasting
confidence: 81%
“…In addition, the same group reported that there is also decreased ligand binding in the cerebellum in AD [81]. However, other studies have demonstrated that the binding of ligand is unaltered in frontal cortex [82] and increased in the infragranular layer [83].…”
Section: Ampa and Kainate Receptorsmentioning
confidence: 88%
“…In contrast in AD, there is not an excessive release of glutamate. However, the number of NMDA and other glutamate receptors is decreased in neocortex and hippocampal regions compared with that in age-matched control subjects (Geddes et al, 1992). This decrease results in an alteration in calcium homeostasis and breakdown of membrane phospholipids due to the stimulation of cPLA 2 and PlsEtn-PLA 2 activities.…”
Section: G Head Injurymentioning
confidence: 92%