Hippocampal formation lesions produce memory impairment in the rhesus monkey

Beason‐Held, Lori L.; Rosene, Douglas L.; Killiany, Ronald; Moss, Mark B.

doi:10.1002/(sici)1098-1063(1999)9:5<562::aid-hipo10>3.0.co;2-x

Cited by 184 publications

(152 citation statements)

References 34 publications

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“…For example, some animal lesion data indicate that recognition can be impaired after selective hippocampal damage (25,26,40), and findings from humans with damage thought to be limited to the hippocampus raise the possibility that item familiarity and contextual recollection may be similarly impaired (31,34,41). Such outcomes are consistent with the perspective that subregions within MTL interact to contribute to recognition memory, with hippocampal computations mediating both item memory and contextual recollection.…”

mentioning

confidence: 67%

“…Although the preceding evidence points to functional differentiation within MTL, other data raise questions regarding whether the hippocampus and perirhinal cortex make distinct contributions to recognition (25,26,(38)(39)(40). For example, some animal lesion data indicate that recognition can be impaired after selective hippocampal damage (25,26,40), and findings from humans with damage thought to be limited to the hippocampus raise the possibility that item familiarity and contextual recollection may be similarly impaired (31,34,41).…”

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confidence: 99%

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Multiple routes to memory: Distinct medial temporal lobe processes build item and source memories

Davachi

Mitchell

Wagner

2003

Proc. Natl. Acad. Sci. U.S.A.

805

647

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A central function of memory is to permit an organism to distinguish between stimuli that have been previously encountered and those that are novel. Although the medial temporal lobe (which includes the hippocampus and surrounding perirhinal, parahippocampal, and entorhinal cortices) is known to be crucial for recognition memory, controversy remains regarding how the specific subregions within the medial temporal lobe contribute to recognition. We used event-related functional MRI to examine the relation between activation in distinct medial temporal lobe subregions during memory formation and the ability (i) to later recognize an item as previously encountered (item recognition) and (ii) to later recollect specific contextual details about the prior encounter (source recollection). Encoding activation in hippocampus and in posterior parahippocampal cortex predicted later source recollection, but was uncorrelated with item recognition. In contrast, encoding activation in perirhinal cortex predicted later item recognition, but not subsequent source recollection. These outcomes suggest that the subregions within the medial temporal lobe subserve distinct, but complementary, learning mechanisms.

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confidence: 67%

mentioning

confidence: 99%

Multiple routes to memory: Distinct medial temporal lobe processes build item and source memories

Davachi

Mitchell

Wagner

2003

Proc. Natl. Acad. Sci. U.S.A.

805

647

View full text Add to dashboard Cite

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“…While controversy remains about the role of the hippocampus proper on recognition memory (Murray and Mishkin 1998), some lesion studies have reported that damage limited to the hippocampal region produces a significant and long-lasting impairment in DNMS delay performance (Zola-Morgan et al 1994;Alvarez et al 1995;Beason-Held et al 1999). Furthermore, when the lesion is extended to the adjacent parahippocampal and perirhinal cortices in monkeys, the memory impairment is more severe (Zola-Morgan et al 1989Alvarez et al 1995).…”

Section: Delayed Nonmatching-to-samplementioning

confidence: 99%

Neuronal and morphological bases of cognitive decline in aged rhesus monkeys

Hara

Rapp

Morrison

2011

AGE

121

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Rhesus monkeys provide a valuable model for studying the basis of cognitive aging because they are vulnerable to age-related decline in executive function and memory in a manner similar to humans. Some of the behavioral tasks sensitive to the effects of aging are the delayed response working memory test, recognition memory tests including the delayed nonmatching-to-sample and the delayed recognition span task, and tests of executive function including reversal learning and conceptual set-shifting task. Much effort has been directed toward discovering the neurobiological parameters that are coupled to individual differences in age-related cognitive decline. Area 46 of the dorsolateral prefrontal cortex (dlPFC) has been extensively studied for its critical role in executive function while the hippocampus and related cortical regions have been a major target of research for memory function. Some of the key age-related changes in area 46 include decreases in volume, microcolumn strength, synapse density, and α1-and α2-adrenergic receptor binding densities. All of these measures significantly correlate with cognitive scores. Interestingly, the critical synaptic subtypes associated with cognitive function appear to be different between the dlPFC and the hippocampus. For example, the dendritic spine subtype most critical to task acquisition and vulnerable to aging in area 46 is the thin spine, whereas in the dentate gyrus, the density of AGE (2012) large mushroom spines with perforated synapses correlates with memory performance. This review summarizes age-related changes in anatomical, neuronal, and synaptic parameters within brain areas implicated in cognition and whether these changes are associated with cognitive decline.

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“…On the one hand, selective hippocampal lesions have been reported to impair recognition memory performance in humans (10), monkeys (11)(12)(13), and rodents (14)(15)(16)(17). Yet, it also has been reported that recognition performance is largely spared by hippocampal lesions (18)(19)(20)(21).…”

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confidence: 99%

Spatial memory, recognition memory, and the hippocampus

Broadbent

Squire

Clark

2004

Proc. Natl. Acad. Sci. U.S.A.

836

577

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There is wide agreement that spatial memory is dependent on the integrity of the hippocampus, but the importance of the hippocampus for nonspatial tasks, including tasks of object recognition memory is not as clear. We examined the relationship between hippocampal lesion size and both spatial memory and object recognition memory in rats. Spatial memory was impaired after bilateral dorsal hippocampal lesions that encompassed 30 -50% total volume, and as lesion size increased from 50% to Ϸ100% of total hippocampal volume, performance was similarly impaired. In contrast, object recognition was intact after dorsal hippocampal lesions that damaged 50 -75% of total hippocampal volume and was impaired only after larger lesions that encompassed 75-100% of hippocampal volume. Last, ventral hippocampal lesions that encompassed Ϸ50% of total hippocampal volume impaired spatial memory but did not affect object recognition memory. These findings show that the hippocampus is important for both spatial memory and recognition memory. However, spatial memory performance requires more hippocampal tissue than does recognition memory.

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Hippocampal formation lesions produce memory impairment in the rhesus monkey

Cited by 184 publications

References 34 publications

Multiple routes to memory: Distinct medial temporal lobe processes build item and source memories

Multiple routes to memory: Distinct medial temporal lobe processes build item and source memories

Neuronal and morphological bases of cognitive decline in aged rhesus monkeys

Spatial memory, recognition memory, and the hippocampus

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