Hippocampal integrity and neurocognition in first-episode schizophrenia: A multidimensional study

Hasan, Alkomiet; Wobrock, Thomas; Falkai, Peter; Schneider‐Axmann, Thomas; Guse, Birgit; Backens, M.; Ecker, Ullrich K. H.; Heimes, Janina; Galea, Joseph M.; Gruber, Oliver; Scherk, Harald

doi:10.3109/15622975.2011.620002

Cited by 41 publications

(24 citation statements)

References 52 publications

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“…In our study, similar to these results, NAA levels in the hippocampus were significantly decreased in the CSPs when compared to healthy controls. Consistent with previous reports, this finding was not found in the FEP group, so it suggests a progressive process in schizophrenia (14)(15)(16)48).…”

Section: Discussionsupporting

confidence: 82%

“…Starting with Nasrallah et al 's study, a decreased hippocampal NAA level was supported by several other studies in schizophrenia patients, and it was reported that NAA decrease in the hippocampus was approximately 22% (52). Considering that the decrease in hippocampal NAA levels is a more consistent result when compared to those in other brain areas such as the frontal cortex, basal ganglion, thalamus, and cingulate cortex in CSPs, it may be interpreted as strong evidence for neuronal/axonal loss in the hippocampus in schizophrenia (14,16,20,(53)(54)(55). In our study, similar to these results, NAA levels in the hippocampus were significantly decreased in the CSPs when compared to healthy controls.…”

Section: Discussionsupporting

confidence: 70%

“…However, several studies reported decreased PFC NAA levels in medicated chronic schizophrenia patients (CSPs) (8,9), first episode patients (FEPs) (7,10,11), and medicated schizophreniform spectrum patients (12). Similarly, several studies reported decreased hippocampal NAA levels (4), and a few studies reported unaltered NAA levels in chronic patients (13,14) and in medicated and unmedicated FEPs (15)(16)(17). Contrasting the above results, FEPs and drug-naive schizophrenia patients showed decreased hippocampal NAA/Cre ratios compared to medicated FEP (18).…”

Section: Introductionmentioning

confidence: 99%

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1H-magnetic resonance spectroscopy in first episode and chronic schizophrenia patients

Kirtaş¹,

Karadağ²,

Şengül³

et al. 2016

Turk J Med Sci

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

1H-magnetic resonance spectroscopy in first episode and chronic schizophrenia patients

Kirtaş¹,

Karadağ²,

Şengül³

et al. 2016

Turk J Med Sci

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“…Two studies found unaltered hippocampal Glx levels in medicated (Hasan et al . ) and unmedicated FEP (Wood et al . ) and in schizophrenia spectrum patients (Wood et al .…”

Section: H‐mrs Findings In Schizophreniamentioning

confidence: 99%

Metabolic alterations associated with schizophrenia: a critical evaluation of proton magnetic resonance spectroscopy studies

Schwerk

Alves

Pouwels

et al. 2013

Journal of Neurochemistry

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By reviewing the existing 1 H-magnetic resonance spectroscopy literature in schizophrenia, the relationship of different sample characteristics and applied methodologies with metabolite alterations is explored. Furthermore, we emphasize common pitfalls and discrepancies in the methodological framework of the reviewed studies that introduce unwanted variation in findings and complicate the comparison of studies. A total of 92 studies were reviewed. Articles were retrieved by searching the Pubmed database. Care was taken to note down reliability and validity measures of each included study. Despite many methodological differences and shortcomings, progressive NAA reductions could be seen in several brain regions implicated in the pathogenesis of schizophrenia. In terms of treatment effects, cross-sectional evidence implicates a normalizing role for atypical antipsychotic medication; however, longitudinal studies remain inconclusive on this issue. Choline, creatine, and myo-inositol levels remain largely unchanged and a time-dependent role of glutamate finds confirmation in several spectroscopy studies. Other findings are less consistent and need further replication. Most studies lack power and methodological precision. Future studies should aim for standardization and for more distinguished study populations to gain more valid and reliable findings.

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“…The hippocampus has well-studied roles in long-term and working memory, which are abilities that are often impaired in people with schizophrenia (Aleman et al, 1999;Libby et al, 2013). A reduction of hippocampal volume and/or alterations of hippocampal asymmetry have been found by independent studies and meta-analyses to associate with schizophrenia (Adriano et al, 2012;Gruber et al, 2008;Hasan et al, 2011;Haukvik et al, 2013;Jaaro-Peled et al, 2010;Shenton et al, 2010;Shepherd et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

A schizophrenia-associated HLA locus affects thalamus volume and asymmetry

Brucato

Guadalupe

Franke

et al. 2015

Brain, Behavior, and Immunity

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a b s t r a c tGenes of the Major Histocompatibility Complex (MHC) have recently been shown to have neuronal functions in the thalamus and hippocampus. Common genetic variants in the Human Leukocyte Antigens (HLA) region, human homologue of the MHC locus, are associated with small effects on susceptibility to schizophrenia, while volumetric changes of the thalamus and hippocampus have also been linked to schizophrenia. We therefore investigated whether common variants of the HLA would affect volumetric variation of the thalamus and hippocampus. We analysed thalamus and hippocampus volumes, as measured using structural magnetic resonance imaging, in 1.265 healthy participants. These participants had also been genotyped using genome-wide single nucleotide polymorphism (SNP) arrays. We imputed genotypes for single nucleotide polymorphisms at high density across the HLA locus, as well as HLA allotypes and HLA amino acids, by use of a reference population dataset that was specifically targeted to the HLA region. We detected a significant association of the SNP rs17194174 with thalamus volume (nominal P = 0.0000017, corrected P = 0.0039), as well as additional SNPs within the same region of linkage disequilibrium. This effect was largely lateralized to the left thalamus and is localized within a genomic region previously associated with schizophrenia. The associated SNPs are also clustered within a potential regulatory element, and a region of linkage disequilibrium that spans genes expressed in the thalamus, including HLA-A. Our data indicate that genetic variation within the HLA region influences the volume and asymmetry of the human thalamus. The molecular mechanisms underlying this association may relate to HLA influences on susceptibility to schizophrenia.

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Hippocampal integrity and neurocognition in first-episode schizophrenia: A multidimensional study

Abstract: These results point to a relationship between verbal memory and hippocampal integrity in schizophrenia patients which might be independent from deficits in other memory domains. Disturbed verbal memory functions in FE-SZ might be linked specifically to hippocampal function.

Cited by 41 publications

References 52 publications

1H-magnetic resonance spectroscopy in first episode and chronic schizophrenia patients

1H-magnetic resonance spectroscopy in first episode and chronic schizophrenia patients

Metabolic alterations associated with schizophrenia: a critical evaluation of proton magnetic resonance spectroscopy studies

A schizophrenia-associated HLA locus affects thalamus volume and asymmetry

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