Hippocampal Interneuronal Dysfunction and Hyperexcitability in a Porcine Model of Concussion

Ulyanova, Alexandra V.; Cottone, Carlo; Adam, Christopher D.; Maheshwari, Nikhil; Grovola, Michael R.; Fruchet, Oceane E.; Alamar, Jami; Koch, Paul F.; Johnson, Victoria E.; Cullen, D. Kacy; Wolf, John A.

doi:10.1101/2022.03.08.483543

Cited by 2 publications

(1 citation statement)

References 94 publications

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“…Patients with epilepsy experience sudden abnormal neural electrical activity, leading to seizures with varying degrees of severity, ranging from minor distractions to a complete loss of consciousness [2]. The unpredictability of this disease imposes significant physical and psychological burdens on patients [3], limiting their social participation and quality of life. Electroencephalography (EEG), as an effective tool for monitoring electrical activity in the brain, has become an indispensable part of epilepsy research [4].…”

Section: Introductionmentioning

confidence: 99%

Technological Vanguard: The Outstanding Performance of the LTY-CNN Model for the Early Prediction of Epileptic Seizures

yang,

Luan,

et al. 2023

Preprint

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Background: Epilepsy is a common neurological disorder that affects approximately 60 million people worldwide. Characterized by unpredictable neural electrical activity abnormalities, it results in seizures with varying intensity levels. Electroencephalography (EEG), as a crucial technology for monitoring and predicting epileptic seizures, plays an essential role in improving the quality of life for people with epilepsy. Method: This study introduces an innovative deep learning model, a lightweight triscale yielding convolutional neural network” (LTY-CNN), that is specifically designed for EEG signal analysis. The model integrates a parallel convolutional structure with a multihead attention mechanism to capture complex EEG signal features across multiple scales and enhance the efficiency achieved when processing time series data. The lightweight design of the LTY-CNN enables it to maintain high performance in environments with limited computational resources while preserving the interpretability and maintainability of the model. Results: In tests conducted on the SWEC-ETHZ and CHB-MIT datasets, the LTY-CNN demonstrated outstanding performance. On the SWEC-ETHZ dataset, the LTY-CNN achieved an accuracy of 99.9%, an area under the receiver operating characteristic curve (AUROC) of 0.99, a sensitivity of 99.9%, and a specificity of 99.8%. Furthermore, on the CHB-MIT dataset, it recorded an accuracy of 99%, an AUROC of 0.932, a sensitivity of 99.1%, and a specificity of 93.2%. These results signify the remarkable ability of the LTY-CNN to distinguish between epileptic seizures and nonseizure events. Compared to other existing epilepsy detection classifiers, the LTY-CNN attained higher accuracy and sensitivity. Conclusion: The high accuracy and sensitivity of the LTY-CNN model demonstrate its significant potential for epilepsy management, particularly in terms of predicting and mitigating epileptic seizures. Its value in personalized treatments and widespread clinical applications reflects the broad prospects of deep learning in the health care sector. This also highlights the crucial role of technological innovation in enhancing the quality of life experienced by patients.

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Section: Introductionmentioning

confidence: 99%

Technological Vanguard: The Outstanding Performance of the LTY-CNN Model for the Early Prediction of Epileptic Seizures

yang,

Luan,

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Technological Vanguard: the outstanding performance of the LTY-CNN model for the early prediction of epileptic seizures

Yang,

Luan,

et al. 2024

J Transl Med

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Background: Epilepsy is a common neurological disorder that affects approximately 60 million people worldwide. Characterized by unpredictable neural electrical activity abnormalities, it results in seizures with varying intensity levels. Electroencephalography (EEG), as a crucial technology for monitoring and predicting epileptic seizures, plays an essential role in improving the quality of life for people with epilepsy. Method: This study introduces an innovative deep learning model, a lightweight triscale yielding convolutional neural network” (LTY-CNN), that is specifically designed for EEG signal analysis. The model integrates a parallel convolutional structure with a multihead attention mechanism to capture complex EEG signal features across multiple scales and enhance the efficiency achieved when processing time series data. The lightweight design of the LTY-CNN enables it to maintain high performance in environments with limited computational resources while preserving the interpretability and maintainability of the model. Results: In tests conducted on the SWEC-ETHZ and CHB-MIT datasets, the LTY-CNN demonstrated outstanding performance. On the SWEC-ETHZ dataset, the LTY-CNN achieved an accuracy of 99.9%, an area under the receiver operating characteristic curve (AUROC) of 0.99, a sensitivity of 99.9%, and a specificity of 98.8%. Furthermore, on the CHB-MIT dataset, it recorded an accuracy of 99%, an AUROC of 0.932, a sensitivity of 99.1%, and a specificity of 93.2%. These results signify the remarkable ability of the LTY-CNN to distinguish between epileptic seizures and nonseizure events. Compared to other existing epilepsy detection classifiers, the LTY-CNN attained higher accuracy and sensitivity. Conclusion: The high accuracy and sensitivity of the LTY-CNN model demonstrate its significant potential for epilepsy management, particularly in terms of predicting and mitigating epileptic seizures. Its value in personalized treatments and widespread clinical applications reflects the broad prospects of deep learning in the health care sector. This also highlights the crucial role of technological innovation in enhancing the quality of life experienced by patients.

show abstract

Hippocampal Interneuronal Dysfunction and Hyperexcitability in a Porcine Model of Concussion

Cited by 2 publications

References 94 publications

Technological Vanguard: The Outstanding Performance of the LTY-CNN Model for the Early Prediction of Epileptic Seizures

Technological Vanguard: The Outstanding Performance of the LTY-CNN Model for the Early Prediction of Epileptic Seizures

Technological Vanguard: the outstanding performance of the LTY-CNN model for the early prediction of epileptic seizures

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