Hippocampal Lipid Homeostasis in APP/PS1 Mice is Modulated by a Complex Interplay Between Dietary DHA and Estrogens: Relevance for Alzheimer’s Disease

Dı́az, Mario; Fabelo, Noemí; Casañas-Sánchez, Verónica; Marín, Raquel; Gómez, Tomás; Quinto-Alemany, David; Pérez, Jose Antonio Pérez

doi:10.3233/jad-150470

Cited by 19 publications

(32 citation statements)

References 79 publications

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“…Up-regulation of reelin is accompanied by increased TGF-β1 (transforming growth factor β1) mRNA, a decrease in that of DNMT1 (DNA (Cytosine-5-)-Methyltransferase 1) and by hypo-methylation of the reelin promoter region. These findings suggest that activation of reelin expression results from DNMT1-dependent hypo-methylation of its gene promoter region, which in turn may be provoked by the increase in TGF-β1 [3,6,7]. Human and mice colon cancer down-regulate reelin, that is accompanied by a slight decrease in α-SMA mRNA levels.…”

Section: S2-4 Human Hmg-coa Lyases: Two Genes Three En-zymes and Onementioning

confidence: 99%

“…(3) , Montoro R.J. (6) , Palés J. (2) , Pié J. , Sánchez D. (8) , y Sánchez-Barceló E. (3) Universities: (1) Autónoma de Madrid, (2) Barcelona, (3) Cantabria, (4) La Laguna, (5) País Vasco, (6) Sevilla, (7) Valencia, (8) Valladolid y (9) Zaragoza The Inter-university Group for Innovative Physiology Teaching (GIDF) has been working over the last decade to educate teachers in methods for more effective teaching of Medical Physiology. This is particularly relevant after the launching of the European Higher Education Area and the Medical Degree in our Universities, whose goal is to train future doctors to provide quality clinical care in the realm of evidence-based Medicine.…”

Section: S7-3mentioning

confidence: 99%

“…Objectives: We evaluated the effects of the microbiota depletion evoked by the oral administration of neomycin and bacitracin on the motor response mediated by 5-HT in mouse ileum. We also studied the gene expression of the 5-HT 2, 5-HT 3 , 5-HT 4 and 5-HT 7 receptors, and SERT in mouse ileum. Methods: Segments of ileum were suspended in an organ bath in the longitudinal direction of the smooth muscle cells.…”

Section: O3-03 Antibiotic-induced Depletion Of Microbiota In-duces Chmentioning

confidence: 99%

“…RELATIONSHIP BETWEEN MATERNAL OBESITY AND FATTY ACID PROFILE OF BREAST MILK Sara García (1) , Nieves Marta Díaz (2) , Maria Virginia Martín (3) , Roberto Dorta (4) , Nieves Guadalupe Acosta (1) , Mercedes Murray (5) , Inmaculada González (6) , Diana Escuder (7) , Covadonga Rodríguez (1) (1) Facultad de Ciencias. Universidad de La Laguna, La Laguna, Spain; (2) Introduction: Pregnancy is characterized by changes in lipid profiles, and an increase of inflammatory response and oxidative stress.…”

Section: P2-05mentioning

confidence: 99%

“…By carrying TTE out, students recognized the useful of this method to evaluate the valves and chambers of the heart from the outside of the body. (1) , Alex Rafacho (2) , Paloma Alonso-Magdalena (3) , Manuel Castellano-Muñoz (4) , Eva María Bru-Tarí (5) , Beatriz Merino (6) , Antonia Ruiz (7) , Esperanza Irles (7) , Melisa Bello (6) , Pau Iborra (8) , Sabrina Villar (7) , Jean Vetorazzi (9) , Manuel Nacher , Ramón Luque (12) , Angel Nadal (7) , Ivan Quesada (7) (1) Departament of Physiology, Genetics and Microbiology, University of Alicante, Sant Vicent del Raspeig, Spain; (2) (CORT-14) is a neuropeptide mainly expressed in the Central Nervous System (CNS) that shows structural homology with somatostatin (SST). It was first discovered by controlling sleep physiology, but besides this central effect it displays many other actions in peripheral tissues including modulation of pancreatic islet function.…”

Section: Introductionmentioning

confidence: 99%

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Abstracts of the XXXVIII Congress of the Spanish Society of Physiological Sciences (SECF), 13-16 September 2016, Zaragoza, Spain

2016

J Physiol Biochem

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Dear colleagues,For the Organising Committee is an honour to host the XXXVIII Congress of the Spanish Society of Physiological Sciences (SECF) in Zaragoza. We are proud to welcome all of the participants to our city during this event that will take place between 13th and 16th September 2016.Throughout the different meetings, the SECF Congress has been considered an important instrument in attaining one of the main objectives of the Society, which is "to generate interest, stimulate research and disseminate knowledge of Physiology and its applications". We hope that this Congress, like all the previous ones, will offer us the opportunity to learn all about the current research activities of our colleagues in the field of physiology, encouraging contact between scientists and facilitating the exchange of information. Different studies will be presented in the form of plenary sessions, symposia and posters and will include superb scientific material that was carefully selected by the Scientific Committee. These studies, originating from laboratories from all over Spain, assure that the meeting will be a major scientific event. Topics cover a wide range of subjects, mainly related to Cell and Molecular Physiology, Neurophysiology, Endocrinology, Cardiovascular Physiology, Respiratory Physiology, Gastrointestinal Physiology, Renal Physiology, Nutrition, metabolism and obesity, Chronobiology, Bioengineering, Teaching of Physiology and Sports Physiology.As President of the Organising Committee, I greatly appreciate the effort of the contributing authors, and especially of the invited speakers, the chairpersons and colleagues from the Organising and Scientific Committees. Last but not least, I would like to express my gratitude to the commercial and institutional sponsors, without whose support it would have been impossible to organise this Congress.We hope this meeting will be fruitful, not only from the scientific point of view but also as a social event. Enjoy the hospitality of Zaragoza, its weather, the taste of its gastronomy and its rich history.Ignacio Giménez President of the Organising Committee J Physiol Biochem (2016) Micro-and nanotechnologies are strongly associated with the design and manufacture of the integrated circuits that are present in the chips of our computer or cell phone, being the basis of the actual technological revolution. Besides being so common in the devices of our daily life, in the near future they are foreseen to interconnect many everyday objects in what is called the Internet of things. These technologies are also an opportunity for many advances in medicine, not only for enhance the communications but to achieve smaller devices with many different features. Among the large amount of devices, it is noteworthy to highlight the pacemakers or cochlear implants. Micro and nanotechnology fabrication processes have achieved astonishing advances in manufacturing chips. I will show that these technologies are more accessible than what is believed and its implementation is possible to prod...

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Section: S2-4 Human Hmg-coa Lyases: Two Genes Three En-zymes and Onementioning

confidence: 99%