2024
DOI: 10.1162/imag_a_00356
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Hippocampal microscopic fractional anisotropy is reduced in temporal lobe epilepsy

Nico J.J. Arezza,
Hana H. Abbas,
Caroline Chadwick
et al.

Abstract: Surgical resection is the method of choice for treating drug-resistant focal temporal lobe epilepsy (TLE). Postsurgical outcomes are better when magnetic resonance imaging (MRI) findings can localize the seizure focus for resection. However, many patients are MR-negative, meaning the focus cannot be differentiated from normal tissue in relaxation-weighted MRI. Diffusion MRI shows promise as a preoperative marker of neuronal abnormalities due to its sensitivity to cellular changes such as axon damage, indexed b… Show more

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