Hippocampal morphology mediates biased memories of chronic pain

Berger, Sara; Vachon-Presseau, Étienne; Abdullah, Taha; Baria, Alex T.; Schnitzer, Thomas J.; Apkarian, A. Vania

doi:10.1016/j.neuroimage.2017.10.030

Cited by 50 publications

(45 citation statements)

References 73 publications

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“…On the other hand, the limbic system, including the hippocampus gyrus, is activated in pain processing [66]. The hippocampus is possibly involved in the formation of pain-associated memory and emotional responses [67,68]. Earlier researches have proposed that the sensory and limbic networks of pain are parallel and independent [25].…”

Section: Altered Functional Connectivity Of Insulamentioning

confidence: 99%

The Reorganization of Insular Subregions in Individuals with Below-Level Neuropathic Pain following Incomplete Spinal Cord Injury

Chen

et al. 2020

Neural Plasticity

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Objective. To investigate the reorganization of insular subregions in individuals suffering from neuropathic pain (NP) after incomplete spinal cord injury (ISCI) and further to disclose the underlying mechanism of NP. Method. The 3D high-resolution T1-weighted structural images and resting-state functional magnetic resonance imaging (rs-fMRI) of all individuals were obtained using a 3.0 Tesla MRI system. A comparative analysis of structure and function connectivity (FC) with insular subareas as seeds in 10 ISCI individuals with below-level NP (ISCI-P), 11 ISCI individuals without NP (ISCI-N), and 25 healthy controls (HCs) was conducted. Associations between the structural and functional alteration of insula subregions and visual analog scale (VAS) scores were analyzed using the Pearson correlation in SPSS 20. Results. Compared with ISCI-N patients, when the left posterior insula as the seed, ISCI-P showed increased FC in right cerebellum VIIb and cerebellum VIII, Brodmann 37 (BA 37). When the left ventral anterior insula as the seed, ISCI-P indicated enhanced FC in right BA18 compared with ISCI-N patients. These increased FCs positively correlated with VAS scores. Relative to HCs, ISCI-P presented increased FC in the left hippocampus when the left dorsal anterior insula was determined as the seed. There was no statistical difference in the volume of insula subregions among the three groups. Conclusion. Our study indicated that distinctive patterns of FC in each subregion of insula suggest that the insular subareas participate in the NP processing through different FC following ISCI. Further, insula subregions could serve as a therapeutic target for NP following ISCI.

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Section: Altered Functional Connectivity Of Insulamentioning

confidence: 99%

The Reorganization of Insular Subregions in Individuals with Below-Level Neuropathic Pain following Incomplete Spinal Cord Injury

Chen

et al. 2020

Neural Plasticity

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“…The headache days per month is often evaluated in the clinical contexts by patient self-report, which may rely on patient memory (Houle et al, 2013;Niere & Jerak, 2004). However, memories may be enhanced to various extents, causing the measurement of headache days to become unreliable or inaccurate (i.e., recall headache days may be higher than the actual headache days) (Berger et al, 2018;Haywood et al, 2018). An objective measurement of headache days per month might be helpful in the decision-making process of providing preventive medication for migraine patients.…”

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confidence: 99%

Neuroimaging features of whole‐brain functional connectivity predict attack frequency of migraine

Chen

Quan

et al. 2019

Human Brain Mapping

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Migraine is a chronic neurological disorder characterized by attacks of moderate or severe headache accompanying functionally and structurally maladaptive changes in brain. As the headache days/month is often measured by patient self-report and tends to be overestimated than actually experienced, the possibility of using neuroimaging data to predict migraine attack frequency is of great interest. To identify neuroimaging features that could objectively evaluate patients' headache days, a total of 179 migraineurs were recruited from two data center with one dataset used as the training/test cohort and the other used as the validating cohort. The guidelines for controlled trials of prophylactic treatment of chronic migraine in adults were used to identify the frequency of attacks and migraineurs were divided into low (MOl) and high (MOh) subgroups. Whole-brain functional connectivity was used to build multivariate logistic regression models with model iteration optimization to identify MOl and MOh. The best model accurately discriminated MOh from MOl with AUC of 0.91 (95%CI [0.86, 0.95]) in the training/test cohort and 0.79 in the validating cohort. The discriminative features were mainly located within the limbic lobe, frontal lobe, and temporal lobe. Permutation tests analysis demonstrated that the classification performance of these features was significantly better than chance. Furthermore, the indicator of functional connectivity had a higher odds ratio than behavioral variables with implementing a holistic regression analysis. The current findings suggested that the migraine attack frequency could be distinguished by using machinelearning algorithms, and highlighted the role of brain functional connectivity in revealing underlying migraine-related neurobiology. K E Y W O R D Sattack frequency, functional connectivity, logistic regression, migraine, prediction | INTRODUCTIONMigraine is a neurological disorder characterized by attacks of moderate or severe headache, and can be divided into episodic migraine (attacks that occur ≤15 days/month) and chronic migraine (attacks Junya Mu and Tao Chen contributed equally to this work.

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“…It is important to bear in mind that pain may not help when recalling events, including those used to rate health-related quality of life [e.g. [47][48]. There is extensive evidence that pain is one of the key determinants of HRQol, including ratings in terms of cognitive functioning [e.g.…”

Section: Discussionmentioning

confidence: 99%

Oral health-related quality of life and cognitive functioning in myofascial temporomandibular disorders pain

Biegańska-Banaś¹,

Gierowski²,

Pihut³

et al. 2019

Arch Psych Psych

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Aim: The aims of the study were to assess whether the Oral Health Related Quality of Life (OHRQoL) is decreased in patients with temporomandibular disorders-myalgic type, to evaluate to what extent myofascial pain intensity affects OHRQoL and to investigate the relationships between cognitive function and OHRQoL. Subject or material and methods: The study included 45 patients diagnosed with the muscle-related temporomandibular disorders. The study group consisted of twenty three people with painful form of disorder. The control consisted of twenty two people without pain experience. The study was a part of a larger research project. The data to be analyzed for this article was obtained in the course of a single questionnaire survey conducted prior to the start of the treatment process. Results: The results show that the study group suffering from myofascial pain experiences related to temporomandibular disorders of myalgic type consistently reported higher quality of life levels than the patient group who reported lack of pain experiences. In principle the better OHRQoL, the poorer cognitive functioning in most neurocognitive domains investigated in the study. Discussion: The results, however surprising, may indicate specific relationships between factors analyzed in the study. These need to be confirmed with larger sample, taking into account general quality of patients life and psychoemotional factors. Conclusions: OHRQoL of patients with temporomandibular disorders shows a co-variation with certain aspects of cognitive functioning. The results should be considered with a caution that is resulting from the limitations of the research sample. cognitive functions, chronic pain, temporomandibular disorders, myofascial pain, Oral Health Related Quality of Life

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Hippocampal morphology mediates biased memories of chronic pain

Cited by 50 publications

References 73 publications

The Reorganization of Insular Subregions in Individuals with Below-Level Neuropathic Pain following Incomplete Spinal Cord Injury

The Reorganization of Insular Subregions in Individuals with Below-Level Neuropathic Pain following Incomplete Spinal Cord Injury

Neuroimaging features of whole‐brain functional connectivity predict attack frequency of migraine

Oral health-related quality of life and cognitive functioning in myofascial temporomandibular disorders pain

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