Hippocampal neural activity reflects the economy of choices during goal‐directed navigation

Tryon, Valerie L.; Penner, Marsha R.; Heide, Shawn W.; King, Hunter O.; Larkin, Joshua D.; Mizumori, Sheri J. Y.

doi:10.1002/hipo.22720

Cited by 35 publications

(35 citation statements)

References 70 publications

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“…Hippocampal activity is altered by changes in contextual features of rewarding stimuli 3,4 , and a population of reward associated cells have been identified in this region 5 . Activity-dependent enhancement of spike firing has been observed at hippocampus-NAc synapses 5,6 , and cocaine strengthens connectivity between the two nuclei 6 , leading us to hypothesize that plasticity of these excitatory synapses is associated with reward.…”

mentioning

confidence: 99%

Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses

LeGates

Kvarta

Tooley

et al. 2018

Nature

224

187

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mentioning

confidence: 99%

Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses

LeGates

Kvarta

Tooley

et al. 2018

Nature

224

187

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“…We are aware of a few papers that were not retrieved by our searches. For example, our searches retrieved a thesis [ 67 ], but not an original relevant publication [ 68 ] which was reprinted as chapter 2 in the thesis.…”

Section: Discussionmentioning

confidence: 99%

Risk-Based Decision Making: A Systematic Scoping Review of Animal Models and a Pilot Study on the Effects of Sleep Deprivation in Rats

et al. 2021

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Animals, including humans, frequently make decisions involving risk or uncertainty. Different strategies in these decisions can be advantageous depending the circumstances. Short sleep duration seems to be associated with more risky decisions in humans. Animal models for risk-based decision making can increase mechanistic understanding, but very little data is available concerning the effects of sleep. We combined primary- and meta-research to explore the relationship between sleep and risk-based decision making in animals. Our first objective was to create an overview of the available animal models for risky decision making. We performed a systematic scoping review. Our searches in Pubmed and Psychinfo retrieved 712 references, of which 235 were included. Animal models for risk-based decision making have been described for rodents, non-human primates, birds, pigs and honey-bees. We discuss task designs and model validity. Our second objective was to apply this knowledge and perform a pilot study on the effect of sleep deprivation. We trained and tested male Wistar rats on a probability discounting task; a “safe” lever always resulted in 1 reward, a “risky” lever resulted in 4 or no rewards. Rats adapted their preferences to variations in reward probabilities (p < 0.001), but 12 h of sleep deprivation during the light phase did not clearly alter risk preference (p = 0.21).

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“…Further, the decoding analysis suggests that ensemble activity in each route carries temporal information of reward delivery. Reward delivery (i.e., reward outcome) is one of the important factors in episodic memory (Mason et al, 2017); it modulates HF neuronal activity (Lee et al, 2012; Tryon et al, 2017; Boccara et al, 2019). These findings suggest that the HF plays an important role in disambiguation of overlapping action (navigation)-reward outcome association.…”

Section: Discussionmentioning

confidence: 99%

Neural Representation of Overlapping Path Segments and Reward Acquisitions in the Monkey Hippocampus

Bretas

Matsumoto

Nishimaru

et al. 2019

Front. Syst. Neurosci.

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Disambiguation of overlapping events is thought to be the hallmark of episodic memory. Recent rodent studies have reported that when navigating overlapping path segments in the different routes place cell activity in the same overlapping path segments were remapped according to different goal locations in different routes. However, it is unknown how hippocampal neurons disambiguate reward delivery in overlapping path segments in different routes. In the present study, we recorded monkey hippocampal neurons during performance of three virtual navigation (VN) tasks in which a monkey alternately navigated two different routes that included overlapping path segments (common central hallway) and acquired rewards in the same locations in overlapping path segments by manipulating a joystick. The results indicated that out of 106 hippocampal neurons, 57 displayed place-related activity (place-related neurons), and 18 neurons showed route-dependent activity in the overlapping path segments, consistent with a hippocampal role in the disambiguation of overlapping path segments. Moreover, 75 neurons showed neural correlates to reward delivery (reward-related neurons), whereas 56 of these 75 reward-related neurons showed route-dependent reward-related activity in the overlapping path segments. The ensemble activity of reward-related neurons represented reward delivery, locations, and routes in the overlapping path segments. In addition, ensemble activity patterns of hippocampal neurons more distinctly represented overlapping path segments than non-overlapping path segments. The present results provide neurophysiological evidence of disambiguation in the monkey hippocampus, consistent with a hippocampal role in episodic memory, and support a recent computational model of “neural differentiation,” in which overlapping items are better represented by repeated retrieval with competitive learning.

show abstract

Hippocampal neural activity reflects the economy of choices during goal‐directed navigation

Cited by 35 publications

References 70 publications

Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses

Reward behaviour is regulated by the strength of hippocampus–nucleus accumbens synapses

Risk-Based Decision Making: A Systematic Scoping Review of Animal Models and a Pilot Study on the Effects of Sleep Deprivation in Rats

Neural Representation of Overlapping Path Segments and Reward Acquisitions in the Monkey Hippocampus

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