Hippocampal neurogenesis facilitates cognitive flexibility in a fear discrimination task
Alonso Martínez-Canabal,
Grecia López-Oropeza,
Francisco Sotres-Bayón
Abstract:Hippocampal neurogenesis, the continuous creation of new neurons in the adult brain, influences memory, regulates the expression of defensive responses to threat (fear), and cognitive processes like pattern separation and behavioral flexibility. One hypothesis proposes that neurogenesis promotes cognitive flexibility by degrading established memories and promoting relearning. Yet, empirical evidence on its role in fear discrimination tasks is scarce. In this study, male rats were initially trained to different… Show more
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