Hippocampal noradrenergic activation is necessary for object recognition memory consolidation and can promote BDNF increase and memory persistence

Mello‐Carpes, Pâmela Billig; Vargas, Liane da Silva de; Gayer, Mateus Cristofari; Roehrs, Rafael; Izquierdo, Iván

doi:10.1016/j.nlm.2015.11.014

Cited by 61 publications

(27 citation statements)

References 38 publications

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“…Noradrenergic signaling is known to be an important regulator of Bdnf expression. Application of norepinephrine to neurons in culture or injection of exogenous norepinephrine in vivo increases Bdnf expression (Chen et al 2007;Mello-Carpes et al 2016). A similar increase in hippocampal Bdnf expression is observed following treatment with antidepressants, including norepinephrine reuptake inhibitors such as reboxetine (Baj et al 2012;Larsen et al 2008;Musazzi et al 2009;Russo-Neustadt et al 2004).…”

Section: Glutamate Receptorsmentioning

confidence: 74%

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A single bout of exercise increases hippocampalBdnf: influence of chronic exercise and noradrenaline

Venezia

Quinlan

Roth

2017

Genes Brain and Behavior

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Research in human subjects suggests that acute exercise can improve memory performance, but the qualities of the exercise necessary to promote improved memory, and the signaling pathways that mediate these effects are unknown. Brain-derived neurotrophic factor (Bdnf), noradrenergic signaling, and post-translational modifications to AMPA receptors have all been implicated in the enhancement of memory following emotional or physical arousal; however, it is not known if a single bout of exercise is sufficient to engage these pathways. Here we use a rodent model to investigate the effects of acute and chronic exercise on hippocampal transcript-specific Bdnf expression and phosphorylation of the GluR1 subunit of the AMPA-type glutamate receptor. A single bout of treadmill exercise was insufficient to mimic the increased expression of GluR1 protein and phosphorylation at Ser845 observed following one month of voluntary wheel running. However, acute exercise was sufficient to increase Bdnf transcript IV mRNA expression in sedentary subjects, but not subjects housed for one month with a running wheel. High-intensity acute exercise increased total Bdnf mRNA in sedentary mice, but not above levels observed following chronic access to the running wheel. Although depletion of central noradrenergic signaling with DSP-4 reduced total Bdnf and Bdnf IV mRNA, the effect of acute exercise on Bdnf mRNA persisted. Our characterization of the effects of acute exercise on Bdnf expression and persistence in the absence of noradrenergic modulation may inform strategies to employ physical activity to combat cognitive aging and mental health disorders.

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Section: Glutamate Receptorsmentioning

confidence: 74%

“…; Mello‐Carpes et al . ). A similar increase in hippocampal Bdnf expression is observed following treatment with antidepressants, including norepinephrine reuptake inhibitors such as reboxetine (Baj et al .…”

mentioning

confidence: 97%

A single bout of exercise increases hippocampalBdnf: influence of chronic exercise and noradrenaline

Venezia

Quinlan

Roth

2017

Genes Brain and Behavior

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“…Later Mello-Carpes et al (2016) endorse this result and showed that hippocampal norepinephrine acting on ß-adrenergic receptors is essential also for object recognition memory consolidation [12]. Its release depends on Nucleus of the Solitary Tract-Nucleus Paragigantocellularis-Locus coeruleus-CA1 region of dorsal hippocampus pathway has been mentioned earlier [13].…”

Section: Molecular Basis Of Hippocampus Memory Functionmentioning

confidence: 91%

“…Besides ß-noradrenergic mechanisms there is also hippocampal mechanisms mediated by brain-derived neurotrophic factor are important for the persistence of fear-motivated long-term memory and object recognition memory [2,12].…”

Section: Molecular Basis Of Hippocampus Memory Functionmentioning

confidence: 99%

Role of the hippocampus in memory functioning: modern view

Assonov

Bozhuk

2017

ZMJ

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The purpose of this review was to develop the comprehensive conception of the hippocampus role in the functioning of human memory, based on data obtained by analysis of the latest scientific literature on the topic and make recommendations for further ways of researches in this topic. The scientific literature of the last 5 years on the role of the hippocampus in memory functioning was analyzed.Based on the reviewed literature, we made the next conclusions: the hippocampus is an extremely important for memory structure with various connections for different types of memory; the hippocampus is affected by a variety of substances, most studied now are glucocorticosteroids, whose effect on memory differs depending on the start time of action; the hippocampus volume in mental disorders affecting memory is less than normal, which makes it an important diagnostic criterion; at the moment, various promising methods that can help in the therapy of PTSD, depression, phobias and other disorders associated with memory impairment and based on the knowledge of the hippocampus for the treatment of memory disorders are being developed. Based on these conclusions and data, which were analyzed, we offered the following recommendations: to implement the hippocampal function examination in the diagnostics of mental disorders, which are accompanied by a violation of its work; to use the size of the hippocampus as one of the prognostic factors for the severity of the memory-associated disorders and the therapy progress; to carefully investigate the difference in the effect of various psychotherapies and pharmacotherapies on the hippocampus to determine exactly which of the therapies is the most morphologically reasonable; to find out how significant the decrease in the hippocampal volume is for the memory functioning; to use pathogenetically and morphologically based methods to improve the function of the hippocampus in the treatment of disorders that are accompanied by memory problems.Роль гіпокампа в роботі пам'яті: сучасний поглядМета роботи -розробити всебічну концепцію ролі гіпокампа у функціонуванні пам'яті людини на основі даних, що отри-мані під час аналізу новітньої наукової літератури з цієї теми, а також виробити рекомендації для дальших досліджень у цій області. Аналізувалась наукова література останніх 5 років про роль гіпокампа у функціонуванні пам'яті.Висновки. Гіпокамп є дуже важливою структурою пам'яті зі зв'язками, які відрізняються для різних типів пам'яті. На гіпокамп впливають різні речовини, найбільш вивченими серед них нині є глюкокортикостероїди, дія яких на пам'ять відрізняється залежно від часу початку їхньої дії. Розмір гіпокампа при психічних розладах, що впливають на пам'ять, менше норми, що робить його важливим діагностичним критерієм. Зараз розробляються різні перспективні методи, що можуть допомогти в терапії посттравматичного стресового розладу, депресії, фобій та інших розладів, котрі пов'язані з погіршенням пам'яті та засновані на знанні гіпокампа для лікування розладів пам'яті. На підставі цих вис...

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“…The vagus nerve mediates visceral stimuli to the LC. The LC communicates with various brain regions via noradrenergic neurons, and activation of LC-noradrenergic pathways improves object recognition [60,61]. The effects of MHBAs on hippocampal NE signaling were further examined, and MHBAs were found to increase NE content and extracellular NE levels in the hippocampus.…”

Section: Mhbas Enhance Cognitive Function Via Activation Of the Vagusmentioning

confidence: 99%

Improving Effects of Hop-Derived Bitter Acids in Beer on Cognitive Functions: A New Strategy for Vagus Nerve Stimulation

2020

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Dementia and cognitive decline are global public health problems. Moderate consumption of alcoholic beverages reduces the risk of dementia and cognitive decline. For instance, resveratrol, a polyphenolic compound found in red wine, has been well studied and reported to prevent dementia and cognitive decline. However, the effects of specific beer constituents on cognitive function have not been investigated in as much detail. In the present review, we discuss the latest reports on the effects and underlying mechanisms of hop-derived bitter acids found in beer. Iso-α-acids (IAAs), the main bitter components of beer, enhance hippocampus-dependent memory and prefrontal cortex-associated cognitive function via dopamine neurotransmission activation. Matured hop bitter acids (MHBAs), oxidized components with β-carbonyl moieties derived from aged hops, also enhance memory functions via norepinephrine neurotransmission-mediated mechanisms. Furthermore, the effects of both IAAs and MHBAs are attenuated by vagotomy, suggesting that these bitter acids enhance cognitive function via vagus nerve stimulation. Moreover, supplementation with IAAs attenuates neuroinflammation and cognitive impairments in various rodent models of neurodegeneration including Alzheimer’s disease. Daily supplementation with hop-derived bitter acids (e.g., 35 mg/day of MHBAs) may be a safe and effective strategy to stimulate the vagus nerve and thus enhance cognitive function.

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Hippocampal noradrenergic activation is necessary for object recognition memory consolidation and can promote BDNF increase and memory persistence

Cited by 61 publications

References 38 publications

A single bout of exercise increases hippocampalBdnf: influence of chronic exercise and noradrenaline

A single bout of exercise increases hippocampalBdnf: influence of chronic exercise and noradrenaline

Role of the hippocampus in memory functioning: modern view

Improving Effects of Hop-Derived Bitter Acids in Beer on Cognitive Functions: A New Strategy for Vagus Nerve Stimulation

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