Hippocampal, parahippocampal and occipital-temporal contributions to associative and item recognition memory: an fMRI study

Yonelinas, Andrew P.; Hopfinger, Joseph B.; Buonocore, Michael H.; Kroll, Neal E. A.; Baynes, Kathleen

doi:10.1097/00001756-200102120-00035

Cited by 222 publications

(158 citation statements)

References 22 publications

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“…The results of the PPI analyses revealed that, in healthy older participants (and not in AD+ patients), the inferior precuneus/PCC was functionally connected to the hippocampus, the inferior parietal cortex and the DLPFC specifically during successful controlled retrieval of the association. The hippocampus has been found to be engaged during retrieval of word pairs (Giovanello et al, 2004(Giovanello et al, , 2009Meltzer and Constable, 2005;Prince et al, 2005;Stark and Squire, 2001), face-name associations (Kirwan and Stark, 2004;Small et al, 2001), face-object associations (Ranganath et al, 2004a), face-spatial location associations (Duzel et al, 2003) and retrieval of an item with its learning context (Slotnick, 2010;Yonelinas et al, 2001). These findings support the idea that the hippocampus plays a role in the use of relational information in declarative memory (Preston et al, 2004).…”

Section: Functional Connectivity During Associative Cermentioning

confidence: 68%

Item familiarity and controlled associative retrieval in Alzheimer's disease: An fMRI study

Genon

Collette

Feyers

et al. 2013

Cortex

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Typical Alzheimer's disease (AD) is characterized by an impaired form of associative memory, recollection, that includes the controlled retrieval of associations. In contrast, familiarity-based memory for individual items may sometimes be preserved in the early stages of the disease. This is the first study that directly examines whole brain regional activity during one core aspect of the recollection function: associative controlled episodic retrieval (CER), contrasted to item familiarity in AD patients. Cerebral activity related to associative CER and item familiarity in AD patients and healthy controls (HC) was measured with functional magnetic resonance imaging during a word-pair recognition task to which the process dissociation procedure was applied. Some patients had null CER estimates (AD-), whereas others did show some CER abilities (AD+), although significantly less than HC. In contrast, familiarity estimates were equivalent in the three groups. In AD+, as in controls, associative CER activated the inferior precuneus/posterior cingulate cortex (PCC). When performing group comparisons, no region was found to be significantly more activated during CER in HC than AD+ and vice versa. However, during associative CER, functional connectivity between this region and the hippocampus, the inferior parietal and dorsolateral prefrontal cortex (DLPFC) was significantly higher in HC than in AD+. In all three groups, item familiarity was related to activation along the intraparietal sulcus (IPS). In conclusion, whereas the preserved automatic detection of an old item (without retrieval of accurate word association) is related to parietal activation centred on the IPS, the inferior precuneus/PCC supports associative CER ability in AD patients, as in HC. However, AD patients have deficient functional connectivity during associative CER, suggesting that the residual recollection function in these patients might be impoverished by the lack of some recollection-related aspects such as autonoetic quality, episodic details and verification.

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Section: Functional Connectivity During Associative Cermentioning

confidence: 68%

Item familiarity and controlled associative retrieval in Alzheimer's disease: An fMRI study

Genon

Collette

Feyers

et al. 2013

Cortex

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“…Increased ER firing to repeats has been observed in monkeys when the repeated stimuli are also the behavioral targets (Suzuki et al, 1997). Some hemodynamic studies have found specific medial temporal activation during intentional recall and experiential recognition over implicit repetition, and lesion studies have found a specific deficit after medial temporal lesions in the same circumstances (Yonelinas et al, 2001;Yonelinas et al, 2002), but both findings are inconsistent (Squire et al, 2004). A variety of evidence in animals has led to the suggestion that familiarity/recognition depends on the repetition-induced decreases in cell firing in more lateral neocortical segments of the ventral temporal lobe, whereas conscious retrieval and recollection depends on medial structures, and especially the HC (Brown and Aggleton, 2001).…”

Section: Repetition and Retrieval Effectsmentioning

confidence: 99%

Processing stages underlying word recognition in the anteroventral temporal lobe

et al. 2006

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The anteroventral temporal lobe integrates visual, lexical, semantic and mnestic aspects of wordprocessing, through its reciprocal connections with the ventral visual stream, language areas, and the hippocampal formation. We used linear microelectrode arrays to probe population synaptic currents and neuronal firing in different cortical layers of the anteroventral temporal lobe, during semantic judgments with implicit priming, and overt word recognition. Since different extrinsic and associative inputs preferentially target different cortical layers, this method can help reveal the sequence and nature of local processing stages at a higher resolution than was previously possible.The initial response in inferotemporal and perirhinal cortices is a brief current sink beginning at 120ms, and peaking at ~170ms. Localization of this initial sink to middle layers suggests that it represents feedforward input from lower visual areas, and simultaneously increased firing implies that it represents excitatory synaptic currents. Until ~800ms, the main focus of transmembrane current sinks alternates between middle and superficial layers, with the superficial focus becoming increasingly dominant after ~550ms. Since superficial layers are the target of local and feedback associative inputs, this suggests an alternation in predominant synaptic input between feedforward and feedback modes. Word repetition does not affect the initial perirhinal and inferotemporal middle layer sink, but does decrease later activity. Entorhinal activity begins later (~200ms), with greater apparent excitatory postsynaptic currents and multiunit activity in neocortically-projecting than hippocampal-projecting layers. In contrast to perirhinal and entorhinal responses, entorhinal responses are larger to repeated words during memory retrieval.These results identify a sequence of physiological activation, beginning with a sharp activation from lower level visual areas carrying specific information to middle layers. This is followed by feedback and associative interactions involving upper cortical layers, which are abbreviated to repeated words. Following bottom-up and associative stages, top-down recollective processes may be driven by entorhinal cortex. Word processing involves a systematic sequence of fast feedforward information transfer from visual areas to anteroventral temporal cortex, followed by prolonged interactions of this feedforward information with local associations, and feedback mnestic information from the medial temporal lobe.

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“…FMRI recall task-Associative memory recall tasks done during functional MRI scanning have repeatedly been shown to result in robust activation of the hippocampal formation (e.g., Killgore 2000;Sperling et al 2001;Stark and Squire 2001;Yonelinas et al 2001;Duzel et al 2003;Sperling et al 2003;Giovanello et al 2004). These studies, and others, document both the role of the hippocampus in recall tasks and the ability of fMRI to measure the functioning of the hippocampus during such tasks.…”

Section: Brain Volume and Functionmentioning

confidence: 99%

“…To evaluate the activity of the hippocampus during a recall task, we followed a design similar to that used by Yonelinas et al (2001). Twenty-four hours before the MRI session, participants were presented with 244 line drawings from the Snodgrass set of pictures (Snodgrass and Vanderwart 1980).…”

Section: Brain Volume and Functionmentioning

confidence: 99%

Reduced Hippocampal Activation During Recall is Associated with Elevated FMR1 mRNA and Psychiatric Symptoms in Men with the Fragile X Premutation

Koldewyn

Hessl

Adams

et al. 2008

Brain Imaging and Behavior

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Recent studies reveal that young carriers of the fragile X premutation are at increased risk for psychiatric conditions, memory problems and executive deficits. Post mortem and structural MRI studies suggest the hippocampus is preferentially affected by the premutation. The current study utilized magnetic resonance imaging (MRI) to explore the relationship between hippocampal structure and function as well as molecular/genetic and psychiatric measures in men with the fragile X premutation. Although the groups did not differ in hippocampal volume, the premutation group showed reduced left hippocampal activation and increased right parietal activation during a recall task relative to controls. These results suggest that brain function underlying memory recall is affected by premutation status. Left hippocampal activation was negatively correlated with both FMR1 mRNA level and psychiatric symptomology in the premutation group. These associations support the theory that increased levels of FMR1 mRNA affect brain function and contribute to psychiatric symptoms.

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Hippocampal, parahippocampal and occipital-temporal contributions to associative and item recognition memory: an fMRI study

Cited by 222 publications

References 22 publications

Item familiarity and controlled associative retrieval in Alzheimer's disease: An fMRI study

Item familiarity and controlled associative retrieval in Alzheimer's disease: An fMRI study

Processing stages underlying word recognition in the anteroventral temporal lobe

Reduced Hippocampal Activation During Recall is Associated with Elevated FMR1 mRNA and Psychiatric Symptoms in Men with the Fragile X Premutation

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