Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol

Ma, Lin-Hui; Wan, Jie; Yan, Jing; Wang, Ning; Liu, Yan-Ping; Wang, Hai-Bi; Zhou, Chenghua; Wu, Yuqing

doi:10.1007/s12035-021-02684-4

Cited by 16 publications

(15 citation statements)

References 47 publications

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“…Which the structural plasticity of hippocampal neurons is crucial for learning and memory has been confirmed in previous studies 14,32 . TEM was used to investigate alterations in the synaptic structure of the hippocampal CA1 area in SNI mice.…”

Section: Resultsmentioning

confidence: 52%

“…In addition, activation of SIRT1 enhances, whereas its loss‐of‐function impairs, dendritic branching, axon development, and axon extension 20,63,64 . Reduced SIRT1 by repeated neonatal propofol exposure plays an important role in cognitive dysfunction by suppressing synaptic plasticity 32 . Besides, in cases of neurotoxicity, SIRT1 may also play an important protective function 65,66 .…”

Section: Discussionmentioning

confidence: 99%

“…Which the structural plasticity of hippocampal neurons is crucial for learning and memory has been confirmed in previous studies. 14,32 TEM was used to investigate alterations in the synaptic structure was reduced as the synaptic fissure widened in SNI mice (Figure 2A-C). Furthermore, the expression of postsynaptic density 95 (PSD95), a crucial postsynaptic protein, was assessed by Western blotting.…”

Section: Chronic Pain Impaired Structural and Functional Synaptic Pla...mentioning

confidence: 99%

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Hippocampal synaptic plasticity injury mediated by SIRT1 downregulation is involved in chronic pain‐related cognitive dysfunction

Liu,

Wang

et al. 2023

CNS Neurosci Ther

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AimsCognitive dysfunction associated with chronic pain may be caused by impaired synaptic plasticity. Considering the impact of silent information regulator 1 (SIRT1) on synaptic plasticity, we explored the exact role of SIRT1 in cognitive impairment caused by chronic pain.MethodsWe evaluated the memory ability of mice with the fear conditioning test (FCT) after spared nerve injury (SNI) model. Western blotting and immunofluorescence were used to analyze the expression levels of SIRT1. Hippocampal synaptic plasticity was detected with Golgi staining, transmission electron microscopy, and long‐term potentiation (LTP). In the intervention study, AAV9‐CaMKIIα‐Cre‐EGFP was injected to SIRT1flox/flox mice to knockdown the expression levels of SIRT1. Besides, SNI mice were injected with AAV2/9‐CaMKIIα‐SIRT1‐3*Flag‐GFP or SRT1720 to increase the expression levels or enzymatic activity of SIRT1.ResultsOur current results indicated that cognitive function in SNI mice was impaired, SIRT1 expression in glutaminergic neurons in the hippocampal CA1 area was downregulated, and synaptic plasticity was altered. Selective knockdown of SIRT1 in hippocampus damaged synaptic plasticity and cognitive function of healthy mice. In addition, the impaired synaptic plasticity and cognitive dysfunction of SNI mice could be improved by the upregulation of SIRT1 expression or enzyme activity.ConclusionsReduced SIRT1 expression in hippocampus of SNI mice may induce cognitive impairment associated with chronic pain by mediating the impaired synaptic plasticity.

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Section: Resultsmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Chronic Pain Impaired Structural and Functional Synaptic Pla...mentioning

confidence: 99%

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Hippocampal synaptic plasticity injury mediated by SIRT1 downregulation is involved in chronic pain‐related cognitive dysfunction

Liu,

Wang

et al. 2023

CNS Neurosci Ther

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“…The silencing information regulator 1 (SIRT1) is an NAD + -dependent deacetylase that regulates gene expression through histone deacetylation and plays a complex role in a variety of diseases [58,59]. It has been reported that SIRT1 plays a vital role in regulating synaptic plasticity [60,61]. However, its mechanism had not yet been fully understood.…”

Section: Hydrogen Sulfide Improves Diabetes-associated Cognitive Dysf...mentioning

confidence: 99%

Hydrogen Sulfide Plays an Important Role by Regulating Endoplasmic Reticulum Stress in Diabetes-Related Diseases

Zhao

Liu

Yang

et al. 2022

IJMS

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Endoplasmic reticulum (ER) plays important roles in protein synthesis, protein folding and modification, lipid biosynthesis, calcium storage, and detoxification. ER homeostasis is destroyed by physiological and pharmacological stressors, resulting in the accumulation of misfolded proteins, which causes ER stress. More and more studies have shown that ER stress contributes to the pathogenesis of many diseases, such as diabetes, inflammation, neurodegenerative diseases, cancer, and autoimmune diseases. As a toxic gas, H2S has, in recent years, been considered the third most important gas signal molecule after NO and CO. H2S has been found to have many important physiological functions and to play an important role in many pathological and physiological processes. Recent evidence shows that H2S improves the body’s defenses to many diseases, including diabetes, by regulating ER stress, but its mechanism has not yet been fully understood. We therefore reviewed recent studies of the role of H2S in improving diabetes-related diseases by regulating ER stress and carefully analyzed its mechanism in order to provide a theoretical reference for future research.

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“…SIRT1 regulates transcription factors, including nuclear factor-E2-related factor 2 (Nrf2), a major regulator in antioxidant defenses, to exert a neuroprotective effect by inducing neurite outgrowth in Neuro-2a cells ( Duangjan et al, 2021 ), peroxisome proliferator-activated receptor coactivator-1α (PGC-1α), a fasting-induced transcriptional coactivator recruited during PPAR stimulation, to restore neuronal network disconnection through reversing synaptic failure in hippocampal neuron in vitro ( Panes et al, 2020 ). In neonatal propofol exposure experiment, SIRT1 was tightly related to synaptic plasticity and neuronal excitability in the hippocampal CA1 region ( Ma et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Sirtuins functions in central nervous system cells under neurological disorders

et al. 2022

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The sirtuins (SIRTs), a class of NAD+ -dependent deacylases, contain seven SIRT family members in mammals, from SIRT1 to SIRT7. Extensive studies have revealed that SIRT proteins regulate virous cell functions. Central nervous system (CNS) decline resulted in progressive cognitive impairment, social and physical abilities dysfunction. Therefore, it is of vital importance to have a better understanding of potential target to promote homeostasis of CNS. SIRTs have merged as the underlying regulating factors of the process of neurological disorders. In this review, we profile multiple functions of SIRT proteins in different cells during brain function and under CNS injury.

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Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol

Cited by 16 publications

References 47 publications

Hippocampal synaptic plasticity injury mediated by SIRT1 downregulation is involved in chronic pain‐related cognitive dysfunction

Hippocampal synaptic plasticity injury mediated by SIRT1 downregulation is involved in chronic pain‐related cognitive dysfunction

Hydrogen Sulfide Plays an Important Role by Regulating Endoplasmic Reticulum Stress in Diabetes-Related Diseases

Sirtuins functions in central nervous system cells under neurological disorders

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