Hippocampal subfields' volumes are more relevant to fluid intelligence than verbal working memory

Zhu, Bi; Chen, Chuansheng; Dang, Xixi; Dong, Qi; Lin, Chongde

doi:10.1016/j.intell.2017.02.003

Cited by 16 publications

(6 citation statements)

References 28 publications

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“…Accordingly, memory consolidation can take place in parallel to task processing. In our study, participants solved matrices which have been related to hippocampus functioning (Colom et al 2013; Zhu et al 2017). Based on the assumption that hippocampal structures are relevant to post-encoding memory consolidation (Dewar et al 2007) and that answering matrices involves the hippocampus, we should have found a detrimental effect of the distraction condition on memory retention in both age groups.…”

Section: Discussionmentioning

confidence: 91%

Wakeful resting and memory retention: a study with healthy older and younger adults

et al. 2018

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Studies indicate that a brief period of wakeful rest after learning supports memory retention, whereas distraction weakens it. It is open for investigation whether advanced age has a significant effect on the impact of post-learning wakeful rest on memory retention for verbal information when compared to a cognitively demanding distraction task. In this study, we examined (1) whether post-learning rest promotes verbal memory retention in younger and older adults and (2) whether the magnitude of the rest benefit changes with increasing age. Younger adults and older adults learned and immediately recalled two consecutive word lists. After one word list, participants rested wakefully for 8 min; after the other list, they solved matrices. Memory performance was again tested in a surprise free recall test at the end of the experimental session. We found that, overall, younger adults outperformed older adults. Also, memory retention was higher following a wakeful rest phase compared to distraction. A detailed analysis revealed that this wakeful rest benefit was significant for the older adults group, whereas the younger adults group retained a similar amount of information in both post-encoding conditions. We assume that older adults can profit more from a wakeful rest phase after learning and are more prone to distraction than younger adults. With increasing age, a short break immediately after information uptake may help better retain the previously learned information, while distraction after learning tends to weaken memory retention.

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Section: Discussionmentioning

confidence: 91%

Wakeful resting and memory retention: a study with healthy older and younger adults

et al. 2018

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“…Raz et al reported smaller hippocampal volume being associated with Gf 33 while Amat et al reported smaller hippocampal volume being associated with full-scale intelligence quotient (IQ) and IQ subscales 34 . Others reported hippocampal volume predicting Gf only in musically trained people 35 , and the volumes of hippocampal subfields being more relevant for Gf than working memory 36 , even though working memory has been linked to Gf 6 . Our current findings add to this prior work, particularly in the context of improved Gf prediction resulting from combination of subcortical regions, including the hippocampus, with cortical regions.…”

Section: Discussionmentioning

confidence: 99%

A multicohort geometric deep learning study of age dependent cortical and subcortical morphologic interactions for fluid intelligence prediction

Besson

Azcona

et al. 2022

Sci Rep

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The relationship of human brain structure to cognitive function is complex, and how this relationship differs between childhood and adulthood is poorly understood. One strong hypothesis suggests the cognitive function of Fluid Intelligence (Gf) is dependent on prefrontal cortex and parietal cortex. In this work, we developed a novel graph convolutional neural networks (gCNNs) for the analysis of localized anatomic shape and prediction of Gf. Morphologic information of the cortical ribbons and subcortical structures was extracted from T1-weighted MRIs within two independent cohorts, the Adolescent Brain Cognitive Development Study (ABCD; age: 9.93 ± 0.62 years) of children and the Human Connectome Project (HCP; age: 28.81 ± 3.70 years). Prediction combining cortical and subcortical surfaces together yielded the highest accuracy of Gf for both ABCD (R = 0.314) and HCP datasets (R = 0.454), outperforming the state-of-the-art prediction of Gf from any other brain measures in the literature. Across both datasets, the morphology of the amygdala, hippocampus, and nucleus accumbens, along with temporal, parietal and cingulate cortex consistently drove the prediction of Gf, suggesting a significant reframing of the relationship between brain morphology and Gf to include systems involved with reward/aversion processing, judgment and decision-making, motivation, and emotion.

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“…The hippocampus is a heterogeneous structure with multiple cell layers and several distinct "hippocampal subfields" (HS) that are structurally and functionally different from one another (Duncan et al, 2012;Leutgeb et al, 2007;Zeineh et al, 2000;Zhu et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Hippocampal subfields in adolescent anorexia nervosa

Myrvang

Vangberg

Stedal

et al. 2018

Psychiatry Research: Neuroimaging

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Patients with anorexia nervosa (AN) exhibit volume reduction in cerebral gray matter (GM), and several studies report reduced hippocampus volume. The hippocampal subfields (HS) are functionally and structurally distinct, and appear to respond differently to neuropathology. The aim of this study was to investigate HS volumes in adolescent females with restrictive AN compared to a healthy age-matched control group (HC). The FreeSurfer v6.0 package was used to extract brain volumes, and segment HS in 58 female adolescents (AN=30, HC=28). We investigated group differences in GM, white matter (WM), whole hippocampus and 12 HS volumes. AN patients had significantly lower total GM and total hippocampal volume. No group difference was found in WM. Volume reduction was found in 11 of the 12 HS, and most results remained significant when adjusting for global brain volume reduction. Investigations of clinical covariates revealed statistically significant relationships between the whole hippocampus, several HS and scores on depression and anxiety scales in AN. Results from this study show that young AN patients exhibit reduced volume in most subfields of the hippocampus, and that this reduction may be more extensive than the observed global cerebral volume loss.

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Hippocampal subfields' volumes are more relevant to fluid intelligence than verbal working memory

Cited by 16 publications

References 28 publications

Wakeful resting and memory retention: a study with healthy older and younger adults

Wakeful resting and memory retention: a study with healthy older and younger adults

A multicohort geometric deep learning study of age dependent cortical and subcortical morphologic interactions for fluid intelligence prediction

Hippocampal subfields in adolescent anorexia nervosa

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