Hippocampal volume, early cognitive decline and gait variability: Which association?

Beauchet, Olivier; Launay, Cyrille P.; Annweiler, Cédric; Allali, Gilles

doi:10.1016/j.exger.2014.11.002

Cited by 58 publications

(78 citation statements)

References 49 publications

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“…Larger ventricular volumes have been associated with slower gait velocity among individuals with dementia [33], but the association is not consistent in healthy older adults [34–37]. In our sample, ventricular volume was not associated with slower gait velocity.…”

Section: Discussioncontrasting

confidence: 71%

The association of brain structure with gait velocity in older adults: a quantitative volumetric analysis of brain MRI

et al. 2015

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Introduction While cortical processes play an important role in controlling locomotion, the underlying structural brain changes associated with slowing of gait in aging are not yet fully established. Our study aimed to examine the relationship between cortical gray matter volume (GM), white matter volume (WM), ventricular volume (VV), hippocampal and hippocampal subfield volumes, and gait velocity in older adults free of dementia. Methods Gait and cognitive performance was tested in 112 community-residing adults, age 70 years and over, participating in the Einstein Aging Study. Gait velocity (cm/s) was obtained using an instrumented walkway. Volumetric MRI measures were estimated using a FreeSurfer software. We examined the cross-sectional relationship of GM, WM, VV, and hippocampal total and subfield volumes and gait velocity using linear regression models. In complementary models, the effect of memory performance on the relationship between gait velocity and regional volumes was evaluated. Results Slower gait velocity was associated with smaller cortical GM and total hippocampal volumes. There was no association between gait velocity and WM or VV. Among hippocampal subfields, only smaller presubiculum volume was significantly associated with decrease in gait velocity. Addition of the memory performance to the models attenuated the association between gait velocity and all volumetric measures. Conclusions Our findings indicate that total GM and hippocampal volumes as well as specific hippocampal subfield volumes are inversely associated with locomotor function. These associations are probably affected by cognitive status of study population.

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Section: Discussioncontrasting

confidence: 71%

The association of brain structure with gait velocity in older adults: a quantitative volumetric analysis of brain MRI

et al. 2015

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“…Thus, more research is needed to better understand the role of the hippocampus in mobility. With some exceptions, the majority of the evidence to date suggests that gray matter is more strongly associated with impaired mobility among community-dwelling older adults without a diagnosis of dementia, compared to white matter, Zimmerman et al 2009;Shimada et al 2013;Beauchet et al 2015). Furthermore, we extend previous studies by demonstrating differences in regional cerebral white matter volume between fallers and non-fallers.…”

Section: Discussionsupporting

confidence: 75%

“…left lateral orbitofrontal cortex, bilateral pars triangularis, and left superior frontal gyrus) (Bench et al 1993;Elliott et al 2000;Aron et al 2003;Cools et al 2004), motor control (i.e. pallidum and hippocampus) (Wichmann and DeLong 1996;Beauchet et al 2015), and memory (i.e., left pars triangularis and hippocampus) (Squire 1992; Badre and Wagner 2007). Notably, lower left lateral orbitofrontal cortex white matter volume at baseline was independently associated with greater decline in set shifting performance over the 12-month period.…”

Section: Discussionmentioning

confidence: 98%

“…Recently, Rosso and colleagues ) extended these previous findings by demonstrating that lower integrity (or high mean diffusivity as measured via diffusion tensor imaging) of normal-appearing gray matter, especially of the hippocampus and anterior cingulate gyrus, was associated with higher step length variability (i.e., poor gait control). A number of cross-sectional studies have found that lower hippocampal volume is associated with poor gait control (Zimmerman et al 2009;Shimada et al 2013;Beauchet et al 2015). Specifically, Beauchet and colleagues (Beauchet et al 2015) recently showed that lower hippocampal volume was associated with higher gait variability among older adults with MCI.…”

Section: Discussionmentioning

confidence: 99%

“…A number of cross-sectional studies have found that lower hippocampal volume is associated with poor gait control (Zimmerman et al 2009;Shimada et al 2013;Beauchet et al 2015). Specifically, Beauchet and colleagues (Beauchet et al 2015) recently showed that lower hippocampal volume was associated with higher gait variability among older adults with MCI. However, among other cognitively healthy older adults, higher hippocampal volume was associated with higher gait variability.…”

Section: Discussionmentioning

confidence: 99%

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Structural neural correlates of impaired mobility and subsequent decline in executive functions: a 12-month prospective study

Hsu

Best

Chiu

et al. 2016

Experimental Gerontology

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Impaired mobility, such as falls, may be an early biomarker of subsequent cognitive decline and is associated with subclinical alterations in both brain structure and function. In this 12-month prospective study, we examined whether there are volumetric differences in gray matter and subcortical regions, as well as cerebral white matter, between older fallers and non-fallers. In addition, we assessed whether these baseline volumetric differences are associated with changes in cognitive function over 12 months. A total of 66 community-dwelling older adults were recruited and categorized by their falls status. Magnetic resonance imaging occurred at baseline and participants' physical and cognitive performances were assessed at baseline and 12-months. At baseline, fallers showed significantly lower volumes in gray matter, subcortical regions, and cerebral white matter compared with non-fallers. Notably, fallers had significantly lower left lateral orbitofrontal white matter volume. Moreover, lower left lateral orbitofrontal white matter volume at baseline was associated with greater decline in set-shifting performance over 12 months. Our data suggest that falls may indicate subclinical alterations in regional brain volume that are associated with subsequent decline in executive functions.

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Apathy in idiopathic normal pressure hydrocephalus: A marker of reversible gait disorders

Allali

Laidet

Armand

et al. 2018

Int J Geriat Psychiatry

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Objective: Apathy-the most common behavioral disturbance in idiopathic normal pressure hydrocephalus (iNPH)-is associated with poor gait, but the role of apathy on gait improvement after cerebrospinal fluid (CSF) tapping has not been studied yet. This study aims to compare gait improvement after CSF tapping in iNPH patients with and without apathy.Methods: Stride time variability (STV), a marker of higher level of gait control, was measured in 33 iNPH patients (78.4 ± 5.7 years; 36.4% women) with an optoelectronic system during usual walking (single task) and during walking while dual tasking of counting and verbal fluency before and 24 hours after CSF tapping. Apathy was defined by a score ≥14 on the Starkstein apathy scale.Results: Apathy was present in 60.6% of patients. Cerebrospinal fluid tapping led to greater improvement of STV (ie, decrease) during dual-task walking (and more specifically categorical verbal fluency) in apathetic compared to nonapathetic patients (−44.7 ± 58.1% versus +4.24 ± 67.6%, respectively; P = .040), even after adjusting for age and depressive symptoms.More severe apathy was correlated with better STV improvement while dual tasking (categorical verbal fluency) after CSF tapping (r = −0.412; P-value = 0.021), while it was not correlated with improvement on executive tests. Conclusions:Our findings suggest that the presence of apathy is a predictor of better outcomes of gait disorders after CSF tapping in patients with iNPH.

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Hippocampal volume, early cognitive decline and gait variability: Which association?

Cited by 58 publications

References 49 publications

The association of brain structure with gait velocity in older adults: a quantitative volumetric analysis of brain MRI

The association of brain structure with gait velocity in older adults: a quantitative volumetric analysis of brain MRI

Structural neural correlates of impaired mobility and subsequent decline in executive functions: a 12-month prospective study

Apathy in idiopathic normal pressure hydrocephalus: A marker of reversible gait disorders

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