Hippocampus and entorhinal cortex in frontotemporal dementia and Alzheimer’s disease: a morphometric MRI study

Laakso, Mikko P.; Frisoni, Giovanni B.; Könönen, Mervi; Mikkonen, Mia; Beltramello, Alberto; Geroldi, Cristina; Bianchetti, Angelo; Trabucchi, Marco; Soininen, Hilkka; Aronen, Hannu J.

doi:10.1016/s0006-3223(99)00306-6

Cited by 168 publications

(105 citation statements)

References 24 publications

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“…Although ERC volumes were not better discriminators of AD or CI from normal elderly controls than hippocampal volumes, consistent with findings from other MRI studies [28,30,34], they were better for differentiating CI versus AD. The present data show that the rate of ERC atrophy increases according to disease severity, i.e.…”

Section: Discussionsupporting

confidence: 89%

Comparison of methods for measuring longitudinal brain change in cognitive impairment and dementia

Cardenas

Hardin

et al. 2003

Neurobiology of Aging

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Purpose: The goal of this project was to compare MRI measures of hippocampal, entorhinal cortex (ERC), and whole brain longitudinal change in cognitively normal elderly controls (C), non-demented subjects with cognitive impairment (CI), and demented (D) subjects.Methods: 16 C, 6 CI, and 7 D subjects of comparable age were studied with MRI twice, at least 1 year apart. Longitudinal change in total brain size was measured by several methods, including computerized segmentation, non-linear warping, and change in the fluid/tissue boundaries between cerebrospinal fluid (CSF) and brain. Change in hippocampal volume was measured by semi-automated methods, and ERC volumes were manually measured.Results: The annual rate of atrophy was greater in D versus C and D versus CI for cortical gray matter (cGM) (P = 0.009 and 0.002), hippocampus (P = 0.0001 and 0.002), and for the change in the fluid/tissue boundary (P = 0.03 and 0.03). The annual rate of atrophy of ERC was greater in both CI and D versus C (P = 0.01 and 0.0002). No significant differences between groups were found using non-linear warping.Conclusions: In CI, the greatest annual rates of atrophy were in ERC, while in D the greatest annual rates of atrophy were in hippocampus and cortex. Progressive ERC atrophy was observed with a greater degree of cognitive impairment, while hippocampal and cortical atrophy were only observed in demented subjects.

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Section: Discussionsupporting

confidence: 89%

Comparison of methods for measuring longitudinal brain change in cognitive impairment and dementia

Cardenas

Hardin

et al. 2003

Neurobiology of Aging

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“…Structural studies indicate that AD may be associated with greater atrophy to the posterior hippocampus in comparison to anterior regions, whereas the reverse profile is seen in SD, with disproportionate anterior compared with posterior hippocampal damage (Laakso et al, 2000;Chan et al, 2001). In rat and monkey brain, the anterior and posterior portions of the hippocampus receive differing afferents via the enthorinal cortex (Witter et al, 1989;Burwell and Amaral, 1998) and electrophysiological studies have observed a higher proportion of neurons signaling aspects of spatial memory in the posterior than anterior hippocampus (Jung et al, 1994;Colombo et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Differentiating the Roles of the Hippocampus and Perirhinal Cortex in Processes beyond Long-Term Declarative Memory: A Double Dissociation in Dementia

Lee¹,

Buckley²,

Gaffan³

et al. 2006

J. Neurosci.

143

139

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There is increasing evidence to suggest that the hippocampus and perirhinal cortex may mediate processes beyond long-term declarative memory. We assessed patients with Alzheimer's disease (AD) or semantic dementia (SD) on a visual oddity judgment task that did not place an explicit demand on long-term memory and is known to be sensitive to hippocampal and perirhinal cortex lesions. Importantly, within the medial temporal lobe, AD is associated with predominant hippocampal atrophy, whereas SD patients have greater perirhinal cortex damage. The AD group was selectively impaired in oddity judgment for scenes, whereas the SD patients demonstrated a deficit in face oddity judgment only. This compelling double dissociation supports the idea that the hippocampus and perirhinal cortex may be critical for the processing of scenes and objects, respectively, in the domain of perception or very short-term working memory.

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“…The research works [7][8][9][10] have found that the rate of volume loss over a certain period of time within the medial temporal lobe is a potential diagnostic marker in Alzheimer's disease. Moreover, lateral ventricles are on average larger in patients with Alzheimer's disease.…”

Section: Introductionmentioning

confidence: 99%

First and Second Order Statistics Features for Classification of Magnetic Resonance Brain Images

Aggarwal¹,

Agrawal²

2012

JSIP

151

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In literature, features based on First and Second Order Statistics that characterizes textures are used for classification of images. Features based on statistics of texture provide far less number of relevant and distinguishable features in comparison to existing methods based on wavelet transformation. In this paper, we investigated performance of texture-based features in comparison to wavelet-based features with commonly used classifiers for the classification of Alzheimer's disease based on T2-weighted MRI brain image. The performance is evaluated in terms of sensitivity, specificity, accuracy, training and testing time. Experiments are performed on publicly available medical brain images. Experimental results show that the performance with First and Second Order Statistics based features is significantly better in comparison to existing methods based on wavelet transformation in terms of all performance measures for all classifiers.

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Hippocampus and entorhinal cortex in frontotemporal dementia and Alzheimer’s disease: a morphometric MRI study

Cited by 168 publications

References 24 publications

Comparison of methods for measuring longitudinal brain change in cognitive impairment and dementia

Comparison of methods for measuring longitudinal brain change in cognitive impairment and dementia

Differentiating the Roles of the Hippocampus and Perirhinal Cortex in Processes beyond Long-Term Declarative Memory: A Double Dissociation in Dementia

First and Second Order Statistics Features for Classification of Magnetic Resonance Brain Images

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