hiPSC-Neural Stem/Progenitor Cell Transplantation Therapy for Spinal
Cord Injury

Du, Xingqiang; Asiamah, Ernest Amponsah; Kong, Desheng; He, Jifeng; Ma, Zhenzhen; Ma, Jun; Cui, Huixian

doi:10.2174/1574888x17666220509222520

Cited by 4 publications

(2 citation statements)

References 84 publications

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“…Pre-clinical studies have shown that NSC transplantation can effectively promote spinal cord repair [ 133 , 134 ]. In various animal models, NSCs have been successfully transplanted into injured spinal cords, and the therapeutic potential, safety and technical challenges of NSCs transplantation have been tested under multiple conditions [ 135 – 137 ]. These cells integrate with the host tissue, forming functional synapses and improving motor and sensory function.…”

Section: Pre-clinical Studiesmentioning

confidence: 99%

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The roles of neural stem cells in myelin regeneration and repair therapy after spinal cord injury

Li,

Luo,

2024

Stem Cell Res Ther

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Spinal cord injury (SCI) is a complex tissue injury that results in a wide range of physical deficits, including permanent or progressive disabilities of sensory, motor and autonomic functions. To date, limitations in current clinical treatment options can leave SCI patients with lifelong disabilities. There is an urgent need to develop new therapies for reconstructing the damaged spinal cord neuron-glia network and restoring connectivity with the supraspinal pathways. Neural stem cells (NSCs) possess the ability to self-renew and differentiate into neurons and neuroglia, including oligodendrocytes, which are cells responsible for the formation and maintenance of the myelin sheath and the regeneration of demyelinated axons. For these properties, NSCs are considered to be a promising cell source for rebuilding damaged neural circuits and promoting myelin regeneration. Over the past decade, transplantation of NSCs has been extensively tested in a variety of preclinical models of SCI. This review aims to highlight the pathophysiology of SCI and promote the understanding of the role of NSCs in SCI repair therapy and the current advances in pathological mechanism, pre-clinical studies, as well as clinical trials of SCI via NSC transplantation therapeutic strategy. Understanding and mastering these frontier updates will pave the way for establishing novel therapeutic strategies to improve the quality of recovery from SCI.

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Section: Pre-clinical Studiesmentioning

confidence: 99%

“…Pre-clinical studies have also evaluated different sources of NSCs, such as fetal spinal cord, adult brain and iPSCs. The use of iPSCs offers an attractive alternative since they can be derived from patients’ own cells, avoiding ethical issues and immune rejection [ 137 ].…”

Section: Pre-clinical Studiesmentioning

confidence: 99%

The roles of neural stem cells in myelin regeneration and repair therapy after spinal cord injury

Li,

Luo,

2024

Stem Cell Res Ther

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Stem cells in central nervous system diseases: Promising therapeutic strategies

Ying,

Zhang,

Zhang

et al. 2023

Experimental Neurology

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Spinal cord neural stem cells derived from human embryonic stem cells promote synapse regeneration and remyelination in spinal cord injury model rats

Wang,

Hu,

Xie

et al. 2024

Eur J of Neuroscience

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Spinal cord injury (SCI) is a devastating injury that significantly impairs patients' quality of life. To date, there is no effective treatment to mitigate nerve tissue damage and restore neurological function. Neural stem cells (NSCs) derived from human embryonic stem cells (hESCs) are considered an important cell source for reconstructing damaged neural circuits and enabling axonal regeneration. Recent preclinical studies have shown that NSCs are potential therapeutic cell sources for neuroprotection and neuroregeneration in SCI animal models. NSCs can be derived from different sources and the spinal cord‐specific NSCs have a higher potential for the regeneration of SCI. However, the long‐term therapeutic efficacy of spinal cord‐specific NSCs remains unproven. Here, we generated human spinal cord NSCs (hSCNSCs) and investigated the effects of transplanted hSCNSCs on the repair of the SCI model rats for 60 days. The transplanted hSCNSCs improved BBB scores, reduced the lesion area and promoted an increase in the number of Nestin‐positive cells in the spinal cord compared to the model rats. Meanwhile, hSCNSC transplantation promoted the expression of synaptophysin, a synaptic signature protein and MBP, a protein associated with remyelination. Interestingly, BAF45D, a chromatin remodelling factor that contributes to the induction of hSCNSCs with region‐specific spinal cord identity, were increased by the hSCNSC transplantation. In addition, conditioned medium derived from the hSCNSCs also promoted regenerative repair of the injured spinal cord. These results demonstrate that hSCNSCs may play a critical role in the regenerative repair of SCI.

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hiPSC-Neural Stem/Progenitor Cell Transplantation Therapy for Spinal Cord Injury

Cited by 4 publications

References 84 publications

The roles of neural stem cells in myelin regeneration and repair therapy after spinal cord injury

The roles of neural stem cells in myelin regeneration and repair therapy after spinal cord injury

Stem cells in central nervous system diseases: Promising therapeutic strategies

Spinal cord neural stem cells derived from human embryonic stem cells promote synapse regeneration and remyelination in spinal cord injury model rats

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