Hirnelektrische Korrelate der Wirkungen zentral d�mpfender chemischer Substanzen im normalen EEG des Erwachsenen

Adams, Arthur E.; Hubach, H

doi:10.1007/bf00242709

Cited by 6 publications

(1 citation statement)

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“…Some of these EEGs were normal, with normal sleep spindles and vertex sharp waves. However, in most a relatively undifferentiated pattern of diffuse beta activity and frequent spindles without vertex sharp waves was seen, which may be related to the hypnotic drugs used [Adams and Hubach, 1960;Fink, 19681. Also, during sleep, focal independent bilateral temporal spikes, and sharp waves were also seen.…”

Section: Resultsmentioning

confidence: 99%

The fra(X) syndrome: Neurological, electrophysiological, and neuropathological abnormalities

et al. 1991

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We have evaluated 62 fragile X syndrome [fra(X)] individuals (55 males and 7 females) with different degrees of developmental disabilities that were clinically non-progressive and non-focal in character. The mean age for the 55 males was 23.1 years +/- 14.3 SD with a range of 2-70: for the 7 females, the mean age was 15.7 years +/- 3.5 SD with a range of 10-20 years. Mental retardation (MR) was found in 53 males (8/53 [15.1%] mild, 26/53 [49.1%] moderate, 14/53 [26.4%] severe, and 5/53 [9.4%] profound). Learning disabilities were found in 2/55 (3.6%) of males. One of the 7 females had mild and one had moderate MR: the other 5 were learning disabled. Autistic stigmata were present in 10/62 (16%) of the patients. Only 14/62 (23%) had a history of seizures, all of which were controlled with anticonvulsants. In 36/62 cases, an electroencephalogram (EEG) was performed. We compared these data with that of others. Brain stem auditory evoked response (BAER) was performed in 12 cases. Abnormalities were found in only 5/12. Neuroimaging and computerized cranial transaxial tomography (CT scan) were performed on 21/62 (34%) of the patients. Only 8 of these 21 (38%) studies were abnormal. One patient died; neuropathological studies showed mild brain atrophy, with light microscopic and ultrastructural abnormalities. Rapid Golgi dendritic spine patterns showed that the proximal apical segments were abnormally developed. Very thin, long tortuous spines with prominent terminal heads and irregular dilatations were present. Marked reductions in the length of the synapses, as determined on EPTA-postfixed tissue where noted.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Resultsmentioning

confidence: 99%