1993
DOI: 10.1007/bf01658706
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Hirschsprung's disease: Clinical and experimental observations

Abstract: Hirschsprung's disease (HD) is a relatively common cause of intestinal obstruction in the newborn. It is characterized by an absence of ganglion cells in the distal bowel beginning at the internal sphincter and extending proximally for varying distances. The etiology of HD-associated enterocolitis remains a complex issue. This study has provided further support for a possible infectious etiology of enterocolitis complicating HD.

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Cited by 31 publications
(12 citation statements)
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“…4 Chromosomal abnormalities such as Down's syndrome are frequently (2 ± 15%) associated with HSCR. 7,8 The relatively constant association of Down's syndrome with HSCR disease suggests the involvement of a modifier gene on chromosome 21 in the pathogenesis of the disease.…”
Section: Introductionmentioning
confidence: 99%
“…4 Chromosomal abnormalities such as Down's syndrome are frequently (2 ± 15%) associated with HSCR. 7,8 The relatively constant association of Down's syndrome with HSCR disease suggests the involvement of a modifier gene on chromosome 21 in the pathogenesis of the disease.…”
Section: Introductionmentioning
confidence: 99%
“…As most (14) of these patients were more than one year old, we think that prolong stasis of fecal matter leads to inflammation of the bowel wall and causes edema & thickening. Puri also mentioned this feature as a diagnostic tool 19 . Spastic colon was found in 7.3% of our patients.…”
Section: Discussionmentioning
confidence: 99%
“…Total aganglionosis is found in 5 % to 15 % of cases of Hirschsprung's disease. According to the literature, many patients with total aganglionosis suffer from malabsorption syndromes and frequent episodes of enterocolitis (2,5,10,18,25).…”
Section: Introductionmentioning
confidence: 99%