Hirsutism, Normal Androgens and Diagnosis of PCOS

Spritzer, Poli Mara; Marchesan, Lucas Bandeira; Santos, Betânia Rodrigues dos; Fighera, Tayane Muniz

doi:10.3390/diagnostics12081922

Cited by 30 publications

(16 citation statements)

References 113 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our finding is consistent with that by Spritzer et al who was found that androgen hormones were related to the development of hirsutism. 23 Hirsutism can occur if the level of these hormones rises or if the body develops a greater sensitivity to them. PCOS is the most prevalent cause of hirsutism.…”

Section: Discussionmentioning

confidence: 99%

Effects of KISS1 structural polymorphism on the risk of polycystic ovary syndrome and reproductive hormones in Iraqi women who take metformin

Kadhem,

Gholizadeh,

Khalaj-Kondori

2023

J Int Med Res

View full text Add to dashboard Cite

Objective To identify the effects of metformin and kisspeptin structural polymorphism on the risk of polycystic ovary syndrome (PCOS) in Iraqi women. Methods Samples were collected at the family planning center of Al-Hassan Teaching Hospital (infertility clinic), Iraq. Hormonal and hematological parameters were measured. Kisspeptin structural polymorphisms were analyzed by polymerase chain reaction using a conventional thermal cycler and Phyre2 predictions. Kisspeptin concentrations were assessed by an enzyme-linked immunosorbent assay. Results Follicle-stimulating hormone (FSH) was the only sex hormone that changed in women with PCOS after metformin treatment. FSH concentrations were significantly increased after therapy compared with before therapy (9.39 ± 2.1 vs 5.13 ± 1.53 IU/L). We found that a single nucleotide polymorphism substituting G to C was related to PCOS. The kisspeptin structural polymorphism showed that the C allele was related to low FSH concentrations after treatment (6.92 ± 2.2 IU/L to 5.34 ± 1.58 IU/L). Kisspeptin concentrations were significantly lower after metformin treatment than before metformin treatment (395.44 ± 67.83 vs 273.18 ± 42.98 ng/mL). Conclusion A variation in the KISS1 gene or its protein structure may be involved in the development of PCOS. The response to metformin may be used as an indicator and could contribute to the early diagnosis and medical therapy of PCOS.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of KISS1 structural polymorphism on the risk of polycystic ovary syndrome and reproductive hormones in Iraqi women who take metformin

Kadhem,

Gholizadeh,

Khalaj-Kondori

2023

J Int Med Res

View full text Add to dashboard Cite

show abstract

“…The diagnosis of hirsutism was based on taking a history and performing a clinical examination with the modified Freeman-Galloway rating score, which examines coarse terminal hairs in nine areas of the body including the upper lip, chin, chest, upper and lower abdomen, arms, and thighs. The severity of hirsutism in each section was scored from 0 to 4 26 . In the summation of scores, women with a level ≥ 4 were considered as hirsute 27 .…”

Section: Methodsmentioning

confidence: 99%

Free androgen index (FAI)’s relations with oxidative stress and insulin resistance in polycystic ovary syndrome

Rahmatnezhad

Moghaddam-Banaem

lak

et al. 2023

Sci Rep

View full text Add to dashboard Cite

This study aimed to determine the levels of the free androgen index (FAI) and its association with oxidative stress and insulin resistance (IR) in patients with polycystic ovary syndrome (PCOS). This cross-sectional study was performed on 160 women aged 18–45 years, visiting gynecology clinics of Urmia in northwestern Iran during 2020–2021 who were diagnosed with PCOS and exhibited one of the four phenotypes of PCOS. All the participants underwent clinical examinations, paraclinical tests, and ultrasounds. FAI cut-off point was considered to be 5%. The significance level was set at < 0.05. Among the 160 participants, the prevalence of the four phenotypes was as follows: phenotype A: 51.9%, phenotype B: 23.1%, phenotype C: 13.1%, and phenotype D: 11.9%. High FAI was detected in 30 participants (18.75%). Additionally, It was found that phenotype C had the highest FAI levels among the PCOS phenotypes, with a significant difference between phenotypes A and C (p value = 0.03). IR was observed in 119 (74.4%) of the participants, and the median (interquartile range: IQR) of malondialdehyde (MDA) levels among the participants was 0.64 (0.86) μM/L. In linear regression, the PCOS phenotype (standard beta = 0.198, p-value = 0.008), follicle-stimulating hormone (FSH) levels (standard beta = 0.213, p-value = 0.004), and MDA levels (standard beta = 0.266, p-value < 0.001) were significantly related to the FAI level, but the homeostatic model assessment for insulin resistance (HOMA-IR) was not statistically associated with FAI. Thus, in this study, PCOS phenotypes and MDA levels (an indicator of stress oxidative) were significantly related to FAI, but HOMA-IR (the indicator of IR) was not associated with it.

show abstract

“…Moreover, there was a significant association of mFG score with androstenedione (A4) and DHEAS from a total of 6,593 PCOS patients distributed across different countries [77]. Using the Rotterdam criteria, US NIH or Androgen Excess Society (AES) criteria, another recent systematic review provided a comprehensive distribution of hirsutism scores in women with PCOS, according to geographic locations [78]. Similar to the different studies, our studies found hirsutism to be a major complaint among medical and dental students.…”

Section: Pcos Among Medical and Dental Studentsmentioning

confidence: 99%

A Review and Meta-Analysis of the Prevalence and Health Impact of Polycystic Ovary Syndrome Among Medical and Dental Students

Coffin¹,

Wray²,

Sah³

et al. 2023

Cureus

View full text Add to dashboard Cite

Women currently comprise the majority of students graduating from medical school and face unique stressors not seen with their male counterparts. In particular, during their medical education, women with polycystic ovary syndrome (PCOS) experience symptoms of the disorder, which strongly impact both their academic and social lives. This in turn influences their academic and professional future. Although women as medical professionals, in general, are happy with their careers, awareness, and understanding on the part of medical educators will definitely be helpful to women medical students in their path to being successful medical professionals. The first objective of our current study is to find the prevalence of PCOS in medical and dental students. The second objective is to find the academic and health impacts of PCOS and what type of interventions are being adopted to relieve the symptoms. Using the keywords such as "PCOS," "medical students," and "dental students", the search engines PubMed, Embase, and Scopus were used to retrieve relevant articles published from 2020 to 2022. After removing the duplicates, 11 prospective cross-sectional studies were utilized for qualitative and quantitative analysis. The pooled prevalence of 2,206 female medical students diagnosed with PCOS was 24.7%. The students in the various studies were aware of their PCOS diagnosis and were taking therapeutic medications. The most common associated complications reported were BMI abnormalities, abnormal hair growth, and acne, along with other complications such as stress and poor academic and social life. The majority also had significant family histories of concurrent clinical conditions such as diabetes, hypertension, and other menstrual abnormalities. Considering the huge impact of PCOS, medical educators, policymakers, and all stakeholders should take proactive measures to accommodate students' needs and bridge the social gap. Special awareness of needed lifestyle changes should be a part of the medical education curriculum for an inclusive educational environment, as it will minimize the gender discrepancy in academic satisfaction and professional life.

show abstract

Hirsutism, Normal Androgens and Diagnosis of PCOS

Cited by 30 publications

References 113 publications

Effects of KISS1 structural polymorphism on the risk of polycystic ovary syndrome and reproductive hormones in Iraqi women who take metformin

Effects of KISS1 structural polymorphism on the risk of polycystic ovary syndrome and reproductive hormones in Iraqi women who take metformin

Free androgen index (FAI)’s relations with oxidative stress and insulin resistance in polycystic ovary syndrome

A Review and Meta-Analysis of the Prevalence and Health Impact of Polycystic Ovary Syndrome Among Medical and Dental Students

Contact Info

Product

Resources

About