Hirudin CGP 39393 as thromboprophylaxis

Williams, David; Mahomed, Anies; Eriksson, B. I.

doi:10.1016/s0140-6736(96)90718-7

Cited by 1 publication

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“…The pharmacokinetics and effects on coagulation parameters have been characterised in healthy human volunteers after s.c. and i.v administration (11)(12)(13)(14)(15)(16). TMREVASC has been assessed in the therapeutic setting for the management of thrombotic events in cardiovascular indications (17)(18)(19)(20)(21) as an anticoagulant during surgical and other interventions (22) and as thromboprophylaxis (23,24).…”

Section: Introductionmentioning

confidence: 99%

Effect of a 15-Minute Infusion of DDAVP on the Pharmacokinetics and Pharmacodynamics of ™REVASC during a Four-Hour Intravenous Infusion in Healthy Male Volunteers

Amin

Mant

Walker³

et al. 1997

Thromb Haemost

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SummaryPlasma pharmacokinetics, effect on coagulation parameters, and safety and tolerability of an intravenous infusion of ™REVASC before, during and after a DDAVP infusion were investigated.Twelve healthy volunteers were given an intravenous bolus dose followed by a constant rate four-hour infusion of ™REVASC. Fifteen-minute infusions of 0.9% saline and DDAVP were started two and three hours respectively after the start of the ™REVASC infusion.Plasma ™REVASC concentrations were not affected by either the saline or DDAVP infusion. ™REVASC infusion produced an increase in APTT which plateaued between 0.5 and 3 hours. After the DDAVP infusion there was a tendency towards a new lower plateau whilst the ™REVASC infusion continued. There were no serious adverse events or bleeding episodes throughout the study.In conclusion, the co-administration of intravenous DDAVP has no effect on the plasma pharmacokinetics of ™REVASC and partially reverses the ™REVASC-induced increase in APTT. This may represent a role for DDAVP in the partial reversal of anticoagulation induced by ™REVASC.

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