Hispidulin inhibits proliferation and enhances chemosensitivity of gallbladder cancer cells by targeting HIF-1α

Gao, Hui; Xie, Jing; Peng, Jianjun; Han, Yantao; Jiang, Qixiao; Han, Mei; Wang, Chunbo

doi:10.1016/j.yexcr.2014.11.021

Cited by 52 publications

(42 citation statements)

References 37 publications

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“…In recent years, accumulating evidence has revealed the pleiotropic effects of hispidulin, including antioxidant, anti‐inflammatory, neuroprotective, antithrombotic, anti‐osteoporotic, and anti‐epileptic activities . More importantly, many in vivo and in vitro studies have reported that hispidulin shows its antitumor effects against a variety of solid tumors and hematological malignancies, including acute myeloid leukemia, hepatocellular carcinoma, colon carcinoma, gallbladder cancer, and renal cell carcinoma . Our previous studies have identified that hispidulin inhibited the growth and metastasis of cells by regulating the activity of sphingosine kinase 1 in renal cell carcinoma .…”

Section: Introductionmentioning

confidence: 99%

Retracted: Hispidulin suppresses cell growth and metastasis by targeting PIM1 through JAK2/STAT3 signaling in colorectal cancer

et al. 2018

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Colorectal cancer (CRC) accounts for over 600 000 deaths annually worldwide. The current study aims to evaluate the value of proto‐oncogene PIM1 as a therapeutic target in CRC and investigate the anticancer activity of hispidulin, a naturally occurring phenolic flavonoid compound, against CRC. Immunohistochemistry analysis showed that PIM1 was upregulated in CRC tissue. The role of PIM1 as an oncogene was evidenced by the fact that PIM1 knockdown inhibits cell growth, induces apoptosis, and suppresses invasion. Our results showed that hispidulin exerts antitumor activity in CRC through inhibiting the expression of PIM1. Moreover, our findings revealed that hispidulin downregulated the expression of PIM1 by inhibiting JAK2/STAT3 signaling by generating reactive oxygen species. Furthermore, our in vivo studies showed that hispidulin can significantly inhibit tumor growth and metastasis in CRC. Collectively, our results provide an experimental basis for trialing hispidulin in CRC treatment. PIM1 can be considered a potential therapeutic target in CRC.

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Section: Introductionmentioning

confidence: 99%

Retracted: Hispidulin suppresses cell growth and metastasis by targeting PIM1 through JAK2/STAT3 signaling in colorectal cancer

et al. 2018

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“…Recent studies have shown that regulating HIF‐1 α in normoxia in tumour cells can significantly affect the cellular behavior of tumour cells, which exhibit relatively higher constitutive HIF‐1 α expression compared with other cell types, and a number of signalling pathways have been proposed to regulate HIF‐1 α expression, including the PTEN/PI3k/Akt, AMPK, JNK, and ERK pathways. Given the modulatory effect of icaritin on PTEN/Akt signalling, this study postulated that icaritin might regulate HIF‐1 α levels via inhibiting the PTEN/Akt signalling pathway in U87MG cells.…”

Section: Discussionmentioning

confidence: 99%

“…To investigate the effects of EMMPRIN or HIF‐1 α on the icaritin‐induced suppression of the invasive potential of U87MG cells, EMMPRIN or HIF‐1 α was overexpressed as previously described . The resulting plasmid was designated pCMV‐EMMPRIN (HIF‐1 α ).…”

Section: Methodsmentioning

confidence: 99%

Icaritin inhibits the invasion and epithelial‐to‐mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF‐1α signalling

Jiang

Han

et al. 2015

Clin Exp Pharma Physio

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SUMMARYIcaritin, a hydrolytic product of icariin from the Epimedium genus, exerts anti-tumour effects on a variety of tumour cell types, mainly by inhibiting cell proliferation and inducing apoptosis. However, little is known about the role of icaritin in cancer invasion and epithelial-to-mesenchymal transition (EMT). In the present study, the glioblastoma (GBM) cell line U87MG was used as a model to investigate the effects of icaritin on the invasion and EMT of cancer cells. The results showed that icaritin significantly inhibited the invasion and EMT of GBM cells by targeting extracellular matrix metalloproteinase (EMMPRIN). Furthermore, the findings strongly indicate that the modulatory effect of icaritin on EMMPRIN is mediated via the PTEN/Akt/HIF-1a signalling pathway. The data provide the first experimental evidence of the inhibitory effect of icaritin on cancer cell invasion and EMT, thus highlighting the potential of icaritin to be employed as a promising anti-cancer agent in the treatment of GBM.

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“…[9][10][11] Although studies on isorhamnetin have reported its anti-cancer efficacy, direct effects on HIF-1α regulation have not been identified. In this study, we observed that isorhamnetin inhibited HIF-1α following induction of HIF-1α accumulation in HCT116 and HT29 cells using hypoxia or CoCl 2 (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…8) Hispidulin, a flavonoid from natural products, in-hibits HIF-1α via AMP-activated protein kinase (AMPK) in gallbladder cancer cells. 9) Luteolin can inhibit free radicals in the bronchial epithelial cells, which decreases HIF-1α. 10) In addition, quercetin can suppress HIF-1α-dependent transcriptional activity in hypoxic colon cancer cells.…”

mentioning

confidence: 99%

Isorhamnetin Inhibits Reactive Oxygen Species-Dependent Hypoxia Inducible Factor (HIF)-1α Accumulation

Seo

et al. 2016

Biological & Pharmaceutical Bulletin

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Isorhamnetin is a flavonoid metabolite of quercetin and isolated from water dropwort (Oenanthe javanica, Umbelliferae). It has been reported that isorhamnetin exerts beneficial effects including antioxidant, anti-inflammatory, and anti-proliferative activities. The present study investigated whether the antioxidant activity of isorhamnetin is correlated with its anti-cancer effects on colorectal cancer cells. Key words colorectal cancer; hypoxia-inducible factor-1α; isorhamnetin; reactive oxygen species Isorhamnetin, a 3′-O-methylated metabolite of quercetin (Figs. 1A, B), is a flavonoid-based compound, which is extracted from Oenanthe javanica, Umbelliferae.

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Hispidulin inhibits proliferation and enhances chemosensitivity of gallbladder cancer cells by targeting HIF-1α

Cited by 52 publications

References 37 publications

Retracted: Hispidulin suppresses cell growth and metastasis by targeting PIM1 through JAK2/STAT3 signaling in colorectal cancer

Retracted: Hispidulin suppresses cell growth and metastasis by targeting PIM1 through JAK2/STAT3 signaling in colorectal cancer

Icaritin inhibits the invasion and epithelial‐to‐mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF‐1α signalling

Isorhamnetin Inhibits Reactive Oxygen Species-Dependent Hypoxia Inducible Factor (HIF)-1α Accumulation

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