Histamine and Cytokine Therapy: Paper presented at the annual meeting of the Swedish Oncology Society, Stockholm, 1997

Hellstrand, Kristoffer; Hermodsson, Svante; Naredi, Peter; Mellqvist, Ulf‐Henrik; Brüne, Martin

doi:10.1080/028418698430566

Cited by 29 publications

(3 citation statements)

References 29 publications

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“…Besides, in addition to maintaining the potent antitumor properties of IL-2, histamine was found to constrain tumor growth in a rat model of prostate adenocarcinoma [65]. Furthermore, clinical data advocate for the co-administration of histamine with IL-2 and/or IFN-α to prolong survival time and to suppress tumors, such as MM and liver melanoma, which are refractory to IL-2 or IFN-α therapy [66]. It is worth highlighting the use of histamine in combination with low-dose IL-2 in a Phase IV trial to prevent the relapse of acute myeloid leukemia and improve overall survival (OS) [66,67].…”

Section: Effects Of Histamine On Antigen-presenting Cellsmentioning

confidence: 99%

“…Furthermore, clinical data advocate for the co-administration of histamine with IL-2 and/or IFN-α to prolong survival time and to suppress tumors, such as MM and liver melanoma, which are refractory to IL-2 or IFN-α therapy [66]. It is worth highlighting the use of histamine in combination with low-dose IL-2 in a Phase IV trial to prevent the relapse of acute myeloid leukemia and improve overall survival (OS) [66,67]. These findings strengthen the importance of combination therapy in cancer treatment and encourage the investigation of histamine as an adjuvant for cancer immunotherapy.…”

Section: Effects Of Histamine On Antigen-presenting Cellsmentioning

confidence: 99%

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Pathophysiological Roles of Histamine Receptors in Cancer Progression: Implications and Perspectives as Potential Molecular Targets

Nguyen

Cho

2021

Biomolecules

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High levels of histamine and histamine receptors (HRs), including H1R~H4R, are found in many different types of tumor cells and cells in the tumor microenvironment, suggesting their involvement in tumor progression. This review summarizes the latest evidence demonstrating the pathophysiological roles of histamine and its cognate receptors in cancer biology. We also discuss the novel therapeutic approaches of selective HR ligands and their potential prognostic values in cancer treatment. Briefly, histamine is highly implicated in cancer development, growth, and metastasis through interactions with distinct HRs. It also regulates the infiltration of immune cells into the tumor sites, exerting an immunomodulatory function. Moreover, the effects of various HR ligands, including H1R antagonists, H2R antagonists, and H4R agonists, on tumor progression in many different cancer types are described. Interestingly, the expression levels of HR subtypes may serve as prognostic biomarkers in several cancers. Taken together, HRs are promising targets for cancer treatment, and HR ligands may offer novel therapeutic potential, alone or in combination with conventional therapy. However, due to the complexity of the pathophysiological roles of histamine and HRs in cancer biology, further studies are warranted before HR ligands can be introduced into clinical settings.

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Section: Effects Of Histamine On Antigen-presenting Cellsmentioning

confidence: 99%

Section: Effects Of Histamine On Antigen-presenting Cellsmentioning

confidence: 99%

Pathophysiological Roles of Histamine Receptors in Cancer Progression: Implications and Perspectives as Potential Molecular Targets

Nguyen

Cho

2021

Biomolecules

View full text Add to dashboard Cite

show abstract

“…Histamine is involved in numerous physiological and pathophysiological processes [6] – immunological response, immunomodulation, inflammation, allergic response, gastric acid secretion, cell proliferation, wound healing, cognitive function, memory, sleep cycle, endocrine homeostasis – and has an influence on release of other neurotransmitters [7] and modulation of tumor growth [8].…”

Section: Introductionmentioning

confidence: 99%