Histamine and H1 Antihistamines

Simons, F. Estelle R.; Akdiş, Cezmi A.

doi:10.1016/b978-0-323-08593-9.00095-4

Cited by 5 publications

(5 citation statements)

References 231 publications

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“…Our study demonstrated that pediatricians used 2nd-GAHs in the ED treatment in only one third of urticaria patients in the pretraining period; however, this rate doubled in the posttraining period. The 2nd-GAHs have been in the market for more than 20 years, and their clinical effectiveness has been demonstrated in all age groups 12,13 . Related studies have ascertained that 2nd-GAHs are superior to 1st-GAHs in the treatment of allergic rhinitis and atopic dermatitis 14,15 .…”

Section: Discussionmentioning

confidence: 99%

“…Besides their superior clinical effectiveness, 2nd-GAHs have a much lower systemic side effect profile than 1st-GAHs, as well 16 . The 2nd-GAHs do not cause sedation and affect cognitive functions because they do not cross the blood-brain barrier 12,13 . Moreover, they have a wide therapeutic dose range and do not develop serious side effects even at high doses 13 .…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, 1st-GAHs are lipophilic drugs that can easily cross the blood-brain barrier, have weak specificity, and low molecular weight; therefore, they suppress the central nervous system and cause significant sedation and cognitive function impairment 17 . Many side effects associated with 1st-GAHs that affect daily life have been reported, such as impaired REM sleep and reduced school success 12 . Even if administered at night, they can cause the deterioration of attention, motor coordination, and memory functions the next day 12 .…”

Section: Discussionmentioning

confidence: 99%

“…Many side effects associated with 1st-GAHs that affect daily life have been reported, such as impaired REM sleep and reduced school success 12 . Even if administered at night, they can cause the deterioration of attention, motor coordination, and memory functions the next day 12 . These side effects are more serious at initial doses and particularly in children with low body mass 17 .…”

Section: Discussionmentioning

confidence: 99%

“…The main reason may be that 1st-GAHs have been used for a longer time in clinical practice than 2nd-GAHs and there is no age restriction for the use of 1st-GAHs, unlike 2nd-GAHs, the use of which is only permitted in children older than 6 months 12 . Additionally, physicians might be regarding 1st-GAHs as more reliable 13 .…”

Section: Discussionmentioning

confidence: 99%

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Do Pediatric Emergency Physicians Comply With Guideline Recommendations in Management of Patients With Acute Urticaria?

Yiğit

Cavkaytar²,

Besli

et al. 2021

Pediatr Emer Care

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Objectives: To determine the level of knowledge and practical preferences of pediatricians regarding acute urticaria (AU) management and to assess the effects of training provided in accordance with the current urticaria guideline recommendations on pediatricians who work in the pediatric emergency department (PED).Methods: A theoretical training was provided to pediatricians regarding the diagnosis and treatment of AU in line with current urticaria guideline recommendations. Before the training, pediatricians completed a 10-item questionnaire. This prospective study assesses their treatment approaches in patients admitted to PED because of AU during the 6-month period before and the 1-year period after training.Results: Four hundred seventeen children in the pretraining and 1085 children in the posttraining periods were treated for AU in PED. Forty-eight pediatricians participated in the training. According to their questionnaire responses, 35% of them used only H 1 antihistamine (AH) treatment, 50% used second-generation H 1 AH (2nd-GAH) as AHs, 75% preferred the oral route of administration, and 85.4% did not administer systemic corticosteroid (sCS) to all patients. Comparing the practice approaches of the pediatricians in the pretraining and posttraining periods, first-generation H 1 antihistamine (1st-GAH) preference rate decreased from 68.4% to 30.3% and the sCS preference rate decreased from 58.5% to 25.7%, while the 2nd-GAH preference rate increased from 31.7% to 69.7% (P < 0.001 for all). No treatments were prescribed for 10.8% of patients before the training and 3% after the training during discharge at home (P < 0.05). Comparing the home treatment choices of the pediatricians in the pretraining and posttraining periods, 1 st -GAH preference rate decreased from 11.5% to 5%, while the 2 nd -GAH preference rate increased from 78.7% to 91.5% (for both parameters, P < 0.001).Conclusions: Practical treatment preferences of pediatricians in the treatment of children with AU differ considerably from both current guideline recommendations and their own theoretical knowledge, and training can enhance pediatricians' compliance with current guideline recommendations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Do Pediatric Emergency Physicians Comply With Guideline Recommendations in Management of Patients With Acute Urticaria?

Yiğit

Cavkaytar²,

Besli

et al. 2021

Pediatr Emer Care

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Analysis of spatiotemporal pattern and quantification of gastrointestinal slow waves caused by anticholinergic drugs

et al. 2017

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ABSTRACT. Anticholinergic drugs are well-known to cause adverse effects, such as constipation, but their effects on baseline contractile activity in the gut driven by slow waves is not well established. In a video-based gastrointestinal motility monitoring (GIMM) system, a mouse's small intestine was placed in Krebs solution and recorded using a high definition camera. Untreated controls were recorded for each specimen, then treated with a therapeutic concentration of the drug, and finally, treated with a supratherapeutic dose of the drug. Next, the video clips showing gastrointestinal motility were processed, giving us the segmentation motions of the intestine, which were then converted via Fast Fourier Transform (FFT) into their respective frequency spectrums. These contraction quantifications were analyzed from the video recordings under standardised conditions to evaluate the effect of drugs. Six experimental trials were included with benztropine and promethazine treatments. Only the supratherapeutic dose of benztropine was shown to significantly decrease the amplitude of contractions; at therapeutic doses of both drugs, neither frequency nor amplitude was significantly affected. We have demonstrated that intestinal slow waves can be analyzed based on the colonic frequency or amplitude at a supratherapeutic dose of the anticholinergic medications. More research is required on the effects of anticholinergic drugs on these slow waves to ascertain the true role of ICC in neurologic control of gastrointestinal motility.

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