Histamine and H1-antihistamines: Celebrating a century of progress

Simons, F. Estelle R.; Simons, Keith J.

doi:10.1016/j.jaci.2011.09.005

Cited by 462 publications

(427 citation statements)

References 124 publications

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“…However, there is not such strong evidence for some indications in this population as in adults. The first generation antihistamines are not indicated in children due to many adverse events connected to activity of these drugs against other than H1 receptors in peripheral tissues' (muscarinic, α-adrenergic and serotonin receptors) and H1 receptors in CNS, or cardiac ion channels [62]. A few years ago Schad and Skoner summarized the role and position of antihistamines for use in children [63].…”

Section: Antihistamines In Paediatric Patients and Patients With Asthmamentioning

confidence: 99%

The role and choice criteria of antihistamines in allergy management – Expert opinion

Kuna

Jurkiewicz

Czarnecka‐Operacz

et al. 2017

Alergologia Polska - Polish Journal of Allergology

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A b s t r a c tAllergic diseases are the most common chronic conditions lasting throughout the patient's life. They not only cause significant deterioration in the quality of life of patients but also lead to significant absenteeism and reduced productivity, resulting in very high costs for society. Effective and safe treatment of allergic diseases is therefore one of the main challenges for public health and should be carried out by all the specialists in family medicine, internists and paediatricians in collaboration with allergists, otorhinolaryngologists and dermatologists. Antihistamines are most commonly used in the treatment of allergies. Several dozen drugs are available on the pharmaceutical market, and their generic forms are advertised widely as very effective drugs for the treatment of allergic diseases. What is the truth? What are the data from clinical trials and observational studies? Are all drugs equally effective and safe for the patient? According to a panel of experts representing various fields of medicine, inappropriate treatment of allergies can be very risky for patients, and seemingly equally acting medications may differ greatly. Therefore, a panel of experts gathered the latest data from the entire scientific literature and analysed the latest standards and recommendations prepared by scientific societies. This paper provides a summary of these studies and highlights the importance for the patient of the proper choice of drug to treat his allergies.Key words: antihistamines, bilastin, allergic rhinitis, urticaria, allergy. Which antihistamines should be chosen according to current standards and recommendations?In the last few decades the incidence of allergic diseases has grown to epidemic status. According to the current data, more than 600 million people suffer from allergic rhinitis worldwide, approximately 25% of them in Europe. In the ECAP trial (Epidemiology of Allergic Diseases in Poland) as many as 30% of respondents reported allergic rhinitis, less than 7% mentioned urticaria, but over 40% of patients had positive skin tests with common inhaled allergens (e.g. plant pollen, dust mites, mould and animal hair). Despite this huge number of patients, these data are frequently underestimated, since allergic diseases are generally believed to be trivial and non-hazardous. However, it has already been proven that allergic rhinitis, asthma and urticaria are associated with a significant socioeconomic burden all over the world -regardless of region, development level and financial status. The total cost of allergic diseases brings both reduced quality of life and also direct costs of drugs and health services as well as indirect social costs such as the absence from work; it also decreases productivity and concentration and generates learning disorders and

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Section: Antihistamines In Paediatric Patients and Patients With Asthmamentioning

confidence: 99%

The role and choice criteria of antihistamines in allergy management – Expert opinion

Kuna

Jurkiewicz

Czarnecka‐Operacz

et al. 2017

Alergologia Polska - Polish Journal of Allergology

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“…H 1 -антигистаминные препараты много лет применяют-ся при лечении аллергических заболеваний [1][2][3][4][5]. История их создания началась в 1910 г., когда британский ученый Dale Henry Hallett открыл гистамин.…”

Section: патофизиологическая роль гистамина и механизмы действия антиunclassified

“…Последние соединены с этиламином через соединительный атом (Х) азота, углерода или кислорода. В отличие от гистамина атом N, входящий в состав боковой группы, является четвертичным и двузамещенным [1][2][3][4].…”

Section: патофизиологическая роль гистамина и механизмы действия антиunclassified

“…В последние годы показано, что эти средства стабилизиру-ют Н 1 -рецептор в неактивном состоянии [3][4][5]. Поэтому их правильнее называть обратными агонистами (рис.…”

Section: патофизиологическая роль гистамина и механизмы действия антиunclassified

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Clinical use of H1-antihistamines

Емельянов¹

2016

Med. sov.

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“…Both oral and intranasal 2 nd generation antihistamines are efficient for treating AR А [5]. Oral medications feature better tolerability, while nasal preparations are characterized by a quicker effect [17]. Systemic antihistamines prevent and diminish such AR symptoms as itching, sneezing, rhinorrhea, but they are less efficient in terms of alleviating nasal obstruction.…”

Section: Antihistaminesmentioning

confidence: 99%

Modern Principles of Allergic Rhinitis Therapy in Children

Вишнёва¹,

Намазова-баранова²,

Алексеева³

et al. 2014

Pediatr. farmakol.

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Modern principles of allergic rhinitis therapy in childrenAllergic diseases, the prevalence rate of which continues to grow, constitute a global issue for the world healthcare. Allergic rhinitis (AR) is a disease widespread among the children and adolescents, causing extensive socio-economic load as well as negative influence on the quality of life of both the patients and the members of their families [1−5]. Moreover, according to the results of the epidemiological studies, 10-40% of AR patients also suffer from bronchial asthma (BA). At the same time, almost 100% of BA patients, at least among the children, complain of AR manifestations. Constant sneezing, itching, rhinorrhea, nasal obstruction, cough and snoring, sleep disorders and fatigue negatively influence physical and psychological condition and social wellbeing, causing downslide in school performance [6]. Despite the presence of excruciating symptoms, the proven interconnection with and the influence on bronchial asthma, the issue of AR is often paid very little attention to, sometimes no more than a usual cold [5]. As a result, most of the pediatric patients either do not receive any adequate therapy they require, or are treated sporadically, taking palliative medications, falling out of modern treatment regimens. One of the reasons of this situation, which is not exclusively typical for our country, is the absence of guidelines on allergic rhinitis in children and its differences from the rhinitis in adults. The acute problem of choosing the correct treatment aiming at controlling the AR

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Histamine and H1-antihistamines: Celebrating a century of progress

Cited by 462 publications

References 124 publications

The role and choice criteria of antihistamines in allergy management – Expert opinion

The role and choice criteria of antihistamines in allergy management – Expert opinion

Clinical use of H1-antihistamines

Modern Principles of Allergic Rhinitis Therapy in Children

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