Histamine and H1-histamine receptors faster venous circulation

Abstract

The study has analysed the action of histamine in the rabbit venous system and evaluated its potential role in contraction during increased venous pressure. We have found that a great variety exists in histamine sensitivity and H1-histamine receptor expression in various types of rabbit veins. Veins of the extremities (saphenous vein, femoral vein, axillary vein) and abdomen (common iliac vein, inferior vena cava) responded to histamine by a prominent, concentration-dependent force generation, whereas great thoracic veins (subclavian vein, superior vena cavas, intrathoracic part of inferior vena cava) and a pelvic vein (external iliac vein) exhibited slight sensitivity to exogenous histamine. The lack of reactivity to histamine was not due to increased activity of nitric oxide synthase (NOS) or heme oxygenase-1. H1-histamine receptor expression of veins correlated well with the histamine-induced contractions. Voltage-dependent calcium channels mediated mainly the histamine-induced force generation of saphenous vein, whereas it did not act in the inferior vena cava. In contrast, the receptor-operated channels were not involved in this response in either vein. Tyrosine phosphorylation occurred markedly in response to histamine in the saphenous vein, but not in the inferior vena cava. Histamine induced a prominent ρ kinase activation in both vessels. Protein kinase C and mitogen-activated protein kinase (MAPK) were not implicated in the histamine-induced intracellular calcium sensitization. Importantly, transient clamping of the femoral vein in animals caused a short-term constriction, which was inhibited by H1-histamine receptor antagonist in vivo. Furthermore, a significantly greater histamine immunopositivity was detected in veins after stretching compared to the resting state. We conclude that histamine receptor density adapts to the actual requirements of the circulation, and histamine liberated by the venous wall during increased venous pressure contributes to the contraction of vessels, providing a force for the venous return.

An Insight into the Triabin Protein Family of American Hematophagous Reduviids: Functional, Structural and Phylogenetic Analysis

“…In brief, vasoconstriction is the first response to a vascular injury, and is activated by second messengers like epinephrine that interact with adrenergic receptors and trigger the release of Ca 2+ of the sarcoplasmic reticulum that activates the calmodulin system in order to induce myogenic contractions. There are other second messengers that can activate the vasoconstriction in blood vessels like tromboxane A 2 (TA 2 ) that interacts with prostanoid receptors and shows effects also in hypertension [ 5 , 6 ].…”

The Effects of a Chactoid Scorpion Venom and Its Purified Toxins on Rat Blood Pressure and Mast Cells Histamine Release

“…Interestingly, from the point of view of scorpion venom pharmacology, the Scorpio maurus palmatus venom evolution regarding hemodynamics effects on blood pressure resembles evolutionary aspects of snake’s venoms. Since it has been reported that scorpion venoms induce mast cell degranulation and histamine release [14,15] and since histamine by activating H1 histamine receptor on endothelial cells [16] and generating nitric oxide produces vasodilation and fast hypotensive effects, we sought to investigate if the hypotensive effect of Scorpio maurus palmatus venom and isolated PlA 2 is mediated by histamine release in vitro (Figure 4) and in vivo (data not shown). Indeed, the Scorpio maurus palmatus venom similar to the reference compound 48/80 induced a dose-dependent degranulation and histamine release from mast cells.…”

Re‐sensitization of desensitized histamine H1 receptors in the human skin takes more than 18 hours

“…However, also low sensitivity may contribute to vasodilatation of post‐capillary resistance vessels. Galajda et al have shown that histamine contributes via H1 receptors to the tone of venous vessels . Experiments were done on isolated veins from rabbits, but the authors suggested similar reactions in humans.…”

“…Subcutaneous histamine injections in rats evoked within five to ten minutes local constriction of veins, increased permeability, haemoconcentration and stasis in venules. Regarding vasodilatation in histamine wheals during the phase of re‐sensitization there can only be speculation based on the studies of Galajda et al mentioned above . Other factors of uncertainty are the varying effects of histamine on blood vessels of different vascular regions both in vitro and in vivo.…”