Kirk-Othmer Encyclopedia of Chemical Technology 2023
DOI: 10.1002/0471238961.0809192010011419.a02
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Histamine and Histamine Receptor Ligands

Abstract: Histamine belongs to the group of biogenic amines and exerts its biological properties mainly mediated by four different G‐protein‐coupled receptor class A subtypes, named H 1 –H 4 receptors. While selective agonists are mainly used for pharmacological experiments, antagonists are widely used in different therapeutic fields. Different generations of H 1 receptor antagonists are mainly used for the treatment of allergic diseases and sleep d… Show more

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