Histamine and its metabolism in mammals part II: Catabolism of histamine and histamine liberation

Maśliński, Cz.

doi:10.1007/bf02026434

Cited by 68 publications

(29 citation statements)

References 615 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Capacity for histamine synthesis in glomeruli may be even higher than suggested by the present results. In our experiments, only one catabolic pathway-diamine oxidase (histaminase)-was inhibited with aminoguanidine (45,48). Because the rat kidney has a very high activity of histamine methyltransferase (31) it cannot be excluded that some portion of de novo-synthesized histamine has been consumed through this other inactivation pathway (45).…”

Section: Resultsmentioning

confidence: 77%

Dynamics of Renal Histamine in Normal Rat Kidney and in Nephrosis Induced by Aminonucleoside of Puromycin

Abboud

Velosa

et al. 1982

J. Clin. Invest.

View full text Add to dashboard Cite

A B S T R A C T Histamine is known to have a profound effect on capillary permeability in nonrenal tissues and this effect is presumably mediated by cyclic (c)AMP. Because in our previous experiments we found that histamine stimulates cAMP accumulation in glomeruli (Torres, V. E., T. E. Northryn, R. M. Edwards, S. V. Shah, and T. P. Dousa. 1978. Modulation of cyclic nucleotides in isolated rat glomeruli. J. Clin. Invest. 62: 1334.), we now explored whether this amine is formed in renal tissue, namely in glomeruli, and whether its renal metabolism is altered in experimental nephrosis induced by puromycin aminonucleoside (PA) in rats. In normal rats, histamine content was higher (A + 240%) in cortex than in medulla. In glomeruli isolated from renal cortex, histamine content was significantly higher (A + 260%) than in tubules. Incubation of isolated glomeruli with L-histidine resulted in a time-dependent increase of histamine content in glomeruli, but no change was found in tubules. The increase in glomerular histamine was blocked by the histidine decarboxylase inhibitor bromocresine. In rats with PA nephrosis induced by a single intraperitoneal injection of PA (15 mg/100 g body wt) urinary excretion of histamine was markedly increased (>A + 200%), but control rats did not differ from rats with PA nephrosis in urinary excretions of L-histidine and of creatinine. At the peak of proteinuria (day 9 after injection of PA) the plasma level of histamine was slightly elevated, and plasma histidine slightly decreased in animals that developed PA nephrosis. The content of histamine was markedly higher and the level of histidine was significantly lower in the renal cortex of PA-nephrotic rats as compared with controls; PA-nephrotic and control rats did not differ in the content of histidine and histamine in the liver. In addition, the content of histamine was higher in glomeruli isolated from PA-nephrotic rats; lesser difference was found in cortical tubules.The results further indicate that PA-nephrotic rats have higher content of histamine in the renal cortex, predominently in glomeruli with increased urinary histamine excretion. The elevated renal cortical histamine is not due to higher availability of histamine precursor L-histidine. Results thus show that glomeruli are a major site of intrarenal histamine synthesis and accumulation, and also suggest that abnormal renal metabolism of this amine in PA nephrosis may be re-

show abstract

Section: Resultsmentioning

confidence: 77%

Dynamics of Renal Histamine in Normal Rat Kidney and in Nephrosis Induced by Aminonucleoside of Puromycin

Abboud

Velosa

et al. 1982

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…Among the various substances identified so far, histamine has long been known to play an important part in acute inflammation. It is present in large quantities in most tissues, synthesized at an increased rate from the precursor, histidine, in acute inflammation [ 19], and is able to elicit some of the features of acute inflammation.…”

Section: Introductionmentioning

confidence: 99%

Effects of histamine agonists and antagonists on luminol-dependent chemiluminescence of granulocytes

Kume

Ōhashi

1984

Agents and Actions

View full text Add to dashboard Cite

Histamine inhibited luminol-dependent chemiluminescence (CL) of granulocytes in a dose-dependent manner, with an ID50 of about 3 X 10(-5) M. Dimaprit, a selective H2-agonist, produced a histamine-like effect. Furthermore, cimetidine, ranitidine, and TZU 0460, which are selective H2-antagonists, but not mepyramine, a selective H1-antagonist, blocked the inhibitory effect of histamine on CL. Thus it may be concluded that the inhibitory effect of histamine is mediated via histamine H2-receptors. H1- and H2-antagonists per se, except at extremely high concentrations, had no effect on CL of granulocytes.

show abstract

“…The rate of change of cortisol concentration (dCort/dt) can be described by a periodic time-dependent production function k in (t) and the first-order elimination rate constant k out : (2) After the administration of methylprednisolone, the inhibitory effect on cortisol secretion can be described by an indirect response model ( Figure 1) 17 : (3) where I max is the maximum inhibitory factor and IC 50 is the concentration of methylprednisolone producing 50% suppression of cortisol circadian secretion. I max was assumed to be equal to 1 and C MP was generated using equation 1.…”

Section: Pharmacodynamicsmentioning

confidence: 99%

“…2 Histamine N-methyltransferase catalyzes the N-methylation of histamine, which was suggested to be the major significant pathway for the biotransformation of histamine in bronchial epithelium and the brain. [3][4][5] Interindividual variation of HNMT activity has been demonstrated in whites and Han Chinese.…”

mentioning

confidence: 99%

Altered Methylprednisolone Pharmacodynamics in Healthy Subjects With Histamine N‐Methyltransferase C314T Genetic Polymorphism

Hon

Jusko

Spratlin

et al. 2006

The Journal of Clinical Pharma

View full text Add to dashboard Cite

This study investigated the potential differences in methylprednisolone pharmacodynamics between healthy subjects with different histamine N-methyltransferase (HNMT) C314T genotypes. Six individuals with C/C genotype and 4 with C/T genotype were administered a single intravenous dose of methylprednisolone 0.6 mg/kg ideal body weight in a randomized 2-period manner. Methylprednisolone plasma concentrations were fitted with a 1-compartment model. Cortisol and whole blood histamine suppression were assessed by indirect response models, with circadian baseline cortisol analyzed by Fourier analysis. The area between the baseline and effect curve and the area under the effect versus time curve suppression ratiowere used to characterize plasma histamine suppression. Methylprednisolone pharmacokinetics and plasma and whole blood histamine suppression were similar between the 2 genotype groups. Median nadir of cortisol and the 50% inhibitory concentration for cortisol were significantly higher in subjects with C/T genotype than those with C/C genotype (P = .031 and .033, respectively, Wilcoxon rank sum test). Subjects who are heterozygous for the T314 variant allele thus appeared less sensitive to the suppressive effects of methylprednisolone on cortisol secretion. KeywordsCorticosteroids; methylprednisolone pharmacodynamics; cortisol suppression; histamine suppression; HNMT polymorphism Histamine is an important mediator in the body that is involved in the regulation of numerous physiologic and pathophysiologic processes including gastric acid secretion, central nervous system functioning, bronchial asthma, and hypersensitivity reactions. It is formed by decarboxylation of histidine, a metabolic pathway that is catalyzed by histidine NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript decarboxylase (HDC) 1 and is metabolized by diamine oxidase and histamine Nmethyltransferase (HNMT). 2 Histamine N-methyltransferase catalyzes the N-methylation of histamine, which was suggested to be the major significant pathway for the biotransformation of histamine in bronchial epithelium and the brain. [3][4][5] Interindividual variation of HNMT activity has been demonstrated in whites and Han Chinese. 6,7 This variability can be explained in part by a C to T transition at nucleotide 314 (exon 4) of the HNMT gene, causing an amino acid change of threonine to isoleucine at codon 115, which results in low immunoreactive HNMT protein and activity. 8 Previously, HNMT activity in red blood cell lysate was found to be lower in persons who are heterozygous for the T314 allele than in those with homozygous wild-type genotype. 7,8 Corticosteroids are widely used for their anti-inflammatory and immunosuppressive effects in various diseases including allergic diseases such as asthma, urticaria, rhinitis, and anaphylaxis. These agents elicit a number of pharmacodynamic responses including suppression of cortisol secretion, cell trafficking, and whole blood histamine (WBH) concentrations. The suppressive effects of c...

show abstract

Histamine and its metabolism in mammals part II: Catabolism of histamine and histamine liberation

Cited by 68 publications

References 615 publications

Dynamics of Renal Histamine in Normal Rat Kidney and in Nephrosis Induced by Aminonucleoside of Puromycin

Dynamics of Renal Histamine in Normal Rat Kidney and in Nephrosis Induced by Aminonucleoside of Puromycin

Effects of histamine agonists and antagonists on luminol-dependent chemiluminescence of granulocytes

Altered Methylprednisolone Pharmacodynamics in Healthy Subjects With Histamine N‐Methyltransferase C314T Genetic Polymorphism

Contact Info

Product

Resources

About