Histamine and its Release from Nasal Polyps: Preliminary Communication

Abstract

Two hundred consecutive patients admitted for polypectomy had no evidence of an increased incidence of allergic disorders. Mast cell degranulation was found on transmission electron microscopy and this resulted in considerable quantities of histamine in polyp extracellular fluid (124–7300 ng/ml). RAST levels of allergen-specific IgE to house-dust mite and mixed-grass pollens were raised in 4 out of 28 cases in polyp fluid, and in only one matched serum. In vitro challenge of polyp tissue with allergen extract and anti-IgE suggested an IgE-mediated response in only 4 of 36 patients.

Role of atopy in chronic rhinosinusitis with nasal polyps: does an atopic condition affect the severity and recurrence of disease?

“…Allergy is more prevalent in chronic rhinosinusitis patients than in control participants, and is associated with more severe manifestations and worse outcomes 6 , 7 . The reported prevalence of allergy in chronic rhinosinusitis with nasal polyps patients varies between 10 per cent and 64 per cent 8 , 9 ; however, some studies have failed to demonstrate an association 10 – 12…”

Epidemiology of chronic rhinosinusitis, selected risk factors, comorbidities, and economic burden

“…The relatively high prevalence and incidence of allergic rhinosinusitis and CRS make it difficult to analyze the interaction: the prevalence of allergic rhino-conjunctivitis was reported with 10–68% [ 129 ], [ 130 ] (Canada: 17% [ 131 ], Finland: 37.3% [95% CI: 33.3–41.2%] [ 27 ]) while an increased prevalence in CRS patients is still controversially discussed [ 1 ].…”

Inhibition of Mediator Release from Dispersed Nasal Polyp Cells by Cyclosporin A

“…A vast array of mediators involved in the allergic reaction are released by airways cells. Polyp–dispersed cells have the potential to produce mediators like arachidonic acid metabolites or histamine upon stimulation by anti–IgE or nonspecific agonists [15, 16, 17, 18, 19, 20, 21]. The release of histamine is, however, less consistent than that of the other mediators [18].…”