Histamine and Leukocytes in Blood During Muscular Work in Man

Dunér, H; Pernow, Bengt

doi:10.3109/00365515809051243

Cited by 46 publications

(23 citation statements)

References 10 publications

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“…The effect of various types of stress on the circulating basophile leucocyte counts was observed in the present study.The metabolic stress(i.e.,food intake) caused a minimal decrease in the basophile counts.RORSMAN(1962)also reported insignificant effect of food intake on the number of circulating basophils in nonallergic persons.The physical stress produced an increase in the basophile counts by 19% which confirms earlier observations by DUNAR and PERNOW(1958). However,a major operative trauma significantly reduced the basophile counts by 60.3%.This reduction is because of multiple factors and may be attributed to excessive secretion of corticosteroids from adrenal cortex during surgery under general anaesthesia.Similarly,a decrease in the basophile counts after a single electro-convulsive shock seems to be due to adrenocortical stimulation.…”

Section: Discussionsupporting

confidence: 86%

“…A course of irradiation therapy reduced the basophile counts significantly as observed earlier (BRAUNSTEINER and THUMB,1958;FREDRICKS and MOLONEY, 1959;BRAUNSTEINER et al,1960).The possible mechanism of basopenia following a long course of irradiation therapy may be due to a generalized depression of leucopoiesis (CRADDOCK et al,1955).Moreover,there is no indication that the basophile leucocytes are radio-resistant (FREDRICKS and MOLONEY,1959).…”

Section: Discussionmentioning

confidence: 69%

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Physiological and Clinical Studies on Norms and Variations in Counts of Circulating Basophile Leucocytes

Baldwa

Goyal²,

Garg³

et al. 1977

Jpn.J.Physiol

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Variations in the counts of circulating basophile leucocytes in 225 subjects were studied. The results obtained are as follows: 1) The counts (per mm3) show a gradual rise with growth, from infancy to adolescence, and maintain a fair constancy in adults. 2) No significant sex difference was found in the peripheral basophile counts. 3) A definite diurnal variation in the counts exists, which is lowest in the morning and highest in the evening. 4) The counts are altered in different phases of the menstrual cycle. 5) Pregnant women show lower counts than nonpregnant women. 6) Surgical trauma and a single electroconvulsive shock lowers the counts significantly but variations are not significant after meals and physical exercise. 7) Smokers have slightly higher counts than non-smokers. 8) A course of irradiation therapy lowers the counts significantly in patients with inoperable neoplastic diseases. 9) Counts show insignificant variation with alteration of blood glucose level. The results mentioned above are discussed.Of the various formed elements of blood being studied by researchers, basophile leucocytes have attracted comparatively little attention. This was partly due to lack of suitable counting methods and ignorance about their functions. A major problem in studying them is the relative paucity of these cells in blood and difficulty in staining. The peripheral counts based on direct examination of blood smears are unreliable because a large number of cells have to be counted in order to obtain an accurate estimation of the number of circulating basophile leucocytes. Moreover, basophils have a tendency to clump together which further complicates the reliability of the smear method. The introduction of the counting chamber method (MOORE and JAMES, 1953) made the counting of peripheral baso-

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 69%

Physiological and Clinical Studies on Norms and Variations in Counts of Circulating Basophile Leucocytes

Baldwa

Goyal²,

Garg³

et al. 1977

Jpn.J.Physiol

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“…It is reasonable to speculate that NCFEX may also be mast cell-dependent because (a) its release was inhibited by the prior administration of DSCG (Fig. 4), an agent thought to act predominantly on mast cells, and (b) the elevation in plasma histamine concentrations (using a modified radioenzymatic assay (14,15)) after exercise or antigen challenge, closely paralleled the increase in NCF.2 However, the possibility that NCFEx may originate from circulating basophils that are known to increase after exercise (34,35) cannot be excluded at this time.…”

Section: Discussionmentioning

confidence: 99%

Identification and partial characterization of an exercise-induced neutrophil chemotactic factor in bronchial asthma.

Lee¹,

Nagy²,

Nagakura³

et al. 1982

J. Clin. Invest.

186

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A B S T R A C T A heat-stable neutrophil chemotactic factor (NCF) has been identified in the serum of 13 atopic asthmatic subjects after treadmill exercise. Peak activity was detected at 10 min and returned to prechallenge values by 1 h. No NCF activity was detected in the sera of three nonasthmatic atopic or four normal nonatopic individuals performing the same task. NCF produced by exercise (NCFEX) had a similar timecourse of release to NCF provoked by specific antigen (NCFAG). The appearance of circulating NCFEX and NCFAG closely paralleled the fall in peak expiratory flow rate/forced expiratory volume in 1 s (PEFR/ FEVI). Histamine challenge in atopic asthmatics at concentrations giving a comparable change in PEFR/ FEVy to that evoked by exercise or inhaled antigen was not associated with the appearance of circulating NCF. In seven subjects NCFEX release was inhibited by prior administration of disodium cromoglycate. NCFEX and NCFAG eluted as single peaks of activity when applied separately to columns of Sephadex G-200, and both were an estimated 750,000 daltons. NCFEX and NCFAG also eluted as single peaks of activity, at between 0.15 and 0.30 M NaCl, following anion exchange chromatography on DEAE-Sephacel (pH 7.8). The isoelectric points of NCFEX and NCFAG were virtually identical (between pH 6.0 and 6.5) as determined by chromatofocusing on Polybuffer Exchanger 94. The activities of NCFEx and NCFAG were substantially reduced, in both a time-and dose-dependent fashion, after incubation with trypsin and chymotrypsin. Partially purified NCFEX and NCFAG promoted both stimulated random migration (chemokinesis) as well as directional migration (chemotaxis).These experiments indicate that NCFEX and NCFAG might be identical substances and raise the possibility

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“…Mean values ± 1 standard error of the mean for the percentage fall in PEFR after each exercise and each histamine challenge for the16 patients who completed all tests. For definition of subgroups see text.…”

mentioning

confidence: 99%

Multiple exercise and histamine challenge in asthmatic patients

Schoeffel¹,

Anderson²,

Gillam³

et al. 1980

Thorax

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We studied the effects of repeated exercise and histamine challenge in asthmatic patients to determine the frequency and degree to which a state of refractoriness was induced by these stimuli. Twenty-nine patients performed three exercise tests, and on a separate day 16 of these patients had three histamine inhalational challenge tests. Forty minutes separated each challenge. Changes in airways resistance were measured using the peak expiratory flow rate (PEFR). The fall in PEFR (expressed as a percentage of the pre-challenge value) was used to quantify the response to challenge. Significant "protection" was defined as a fall in PEFR after a repeated challenge less than 50% of the fall observed on the first challenge. All patients had a fall in PEFR greater than 220% on the first challenge of the day. With repeated exercise 28 out of 29 patients had a fall in PEFR less than that observed on the first test and 12 had significant "protection". The fall in PEFR after the third exercise challenge was not significantly different to the second challenge and a "plateau" effect was observed. There was no significant difference in the fall in PEFR after the first and second histamine challenge although two of the 16 patients were significantly protected. After the third histamine challenge five of the 16 patients were significantly protected from the effects of the same dose of histamine. The degree to which repeated exercise challenge induces a diminished response is variable. With repeated challenge the response to histamine remains relatively constant in most

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Histamine and Leukocytes in Blood During Muscular Work in Man

Cited by 46 publications

References 10 publications

Physiological and Clinical Studies on Norms and Variations in Counts of Circulating Basophile Leucocytes

Physiological and Clinical Studies on Norms and Variations in Counts of Circulating Basophile Leucocytes

Identification and partial characterization of an exercise-induced neutrophil chemotactic factor in bronchial asthma.

Multiple exercise and histamine challenge in asthmatic patients

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