Histamine and Microglia

Iida, Takahiro; Yanai, Kazuhiko; Yoshikawa, Takeo

doi:10.1007/7854_2022_322

Cited by 5 publications

(2 citation statements)

References 113 publications

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“…The excellent recent literature reports the presence and the role of many microglia-expressed receptor families. Purinergic, serotoninergic, histaminergic, and cannabinoid receptors are the most relevant in tuning the microglia state by regulating their phenotypic characteristics and functions, including proliferation, branch motility, cytokine release, cell migration, and phagocytosis, in physiological [ 60 , 61 , 62 , 63 , 64 ] and pathological conditions, including neurodegenerative diseases [ 65 , 66 , 67 , 68 , 69 , 70 , 71 ]. Although supported by limited evidence in the literature, it is worth mentioning that microglia also express GABAergic, cholinergic, adrenergic, and dopaminergic receptors [ 45 , 72 ].…”

Section: Glutamate Receptors Expressed In Microgliamentioning

confidence: 99%

The Physio-Pathological Role of Group I Metabotropic Glutamate Receptors Expressed by Microglia in Health and Disease with a Focus on Amyotrophic Lateral Sclerosis

Balbi

Bonanno

Bonifacino

et al. 2023

IJMS

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Microglia cells are the resident immune cells of the central nervous system. They act as the first-line immune guardians of nervous tissue and central drivers of neuroinflammation. Any homeostatic alteration that can compromise neuron and tissue integrity could activate microglia. Once activated, microglia exhibit highly diverse phenotypes and functions related to either beneficial or harmful consequences. Microglia activation is associated with the release of protective or deleterious cytokines, chemokines, and growth factors that can in turn determine defensive or pathological outcomes. This scenario is complicated by the pathology-related specific phenotypes that microglia can assume, thus leading to the so-called disease-associated microglia phenotypes. Microglia express several receptors that regulate the balance between pro- and anti-inflammatory features, sometimes exerting opposite actions on microglial functions according to specific conditions. In this context, group I metabotropic glutamate receptors (mGluRs) are molecular structures that may contribute to the modulation of the reactive phenotype of microglia cells, and this is worthy of exploration. Here, we summarize the role of group I mGluRs in shaping microglia cells’ phenotype in specific physio-pathological conditions, including some neurodegenerative disorders. A significant section of the review is specifically focused on amyotrophic lateral sclerosis (ALS) since it represents an entirely unexplored topic of research in the field.

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Section: Glutamate Receptors Expressed In Microgliamentioning

confidence: 99%

The Physio-Pathological Role of Group I Metabotropic Glutamate Receptors Expressed by Microglia in Health and Disease with a Focus on Amyotrophic Lateral Sclerosis

Balbi

Bonanno

Bonifacino

et al. 2023

IJMS

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“…HA is primarily derived from histaminergic neurons expressing histidine decarboxylase (HDC), which are located solely in the tuberomammillary nucleus in the posterior hypothalamus and project axons throughout the brain [19]. HA exerts its function by mobilizing four G protein-coupled receptors (H1R, H2R, H3R, and H4R) [20]. Several reports demonstrated that histamine modulates the proliferation and differentiation of neural stem cells and contributes to synaptic plasticity during embryonic and postnatal development [21].…”

Section: Histaminementioning

confidence: 99%

Potential of Heterogeneous Compounds as Antidepressants: A Narrative Review

Zhang

Wang

et al. 2022

IJMS

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Depression is a globally widespread disorder caused by a complicated interplay of social, psychological, and biological factors. Approximately 280 million people are suffering from depression worldwide. Traditional frontline antidepressants targeting monoamine neurotransmitters show unsatisfactory effects. The development and application of novel antidepressants for dissimilar targets are on the agenda. This review characterizes the antidepressant effects of multiple endogenous compounds and/or their targets to provide new insight into the working mechanism of antidepressants. We also discuss perspectives and challenges for the generation of novel antidepressants.

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