Histamine as an Intracellular Messenger in Human Platelets

Histamine

“…The importance of histamine in regulating the function of lymphocytes, monocytes, or platelets has been inferred from previous studies. 10,25,26 Because HDC is necessary for the synthesis of histamine, the use of α-fluoro-methyl histidine provides a relatively specific means with which to inhibit its production. The compound N´Ndiethyl-2-4-(phenylmethyl) phenoxyethan-amine-HCl has been characterized as an inhibitor of the H IC "receptor" and as a cell permanent antagonist that can be used in conjunction with α-fluoro-methyl histidine to define the functional role of intracellular histamine.…”

Increased histidine decarboxylase expression during in vitro monocyte maturation; a possible role of endogenously synthesised histamine in monocyte/macrophage differentiation

“…The question obviously arises, how does histamine mediate differentiation of monocytes through a yet not characterized intracellular interaction. Histamine may play a similar role to polyamines: putrescine, spermine and spermidine, as it belongs to this group of compounds on the basis of its structure [27]. Considering these data a function similar to second messengers can be assumed but the precise mechanism of effects is still obscure.…”