Histamine‐binding suppressor T cells in rabbit peripheral blood

Vaeck, Mark; Smet, W. De; Baetseĺier, Patrick De

doi:10.1002/eji.1830100810

Cited by 12 publications

(5 citation statements)

References 24 publications

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“…The presence of histamine receptors on mononuclear cells in peripheral blood, and the suppressive role of these cells in inflammation, were confirmed in animal models. Further studies showed that histamine-binding peripheral blood T lymphocytes are responsible for inhibition of inflammation [5]. In 1992, Shibata et al .…”

Section: Histamine As Immunomodulator Of Lymphocyte Activitymentioning

confidence: 99%

State of the art paper T lymphocytes as a target of histamine action

Kmiecik

Otocka-Kmiecik²,

Górska-Ciebiada³

et al. 2012

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Histamine is one of the most important biogenic amines in medicine and biology but its role in allergy, autoimmune and neoplastic diseases has not yet been fully defined. The last few years have brought many discoveries concerning important modulatory effects of histamine and its receptors on basic mechanisms of the immunological processes. The role of histamine H1 and H2 receptors in immunomodulation has been established. The immunomodulatory function of a newly described histamine H4 receptor has been revealed. One of the most important modulatory effects of histamine currently studied is its influence on T lymphocyte differentiation and function. Our present knowledge suggests that histamine may have a wider influence on various immunological processes than is now accepted; therefore, we need further studies to fully clarify the role of histamine and its receptors. This knowledge can bring new therapeutic solutions in allergies, autoimmune diseases and malignancies.

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Section: Histamine As Immunomodulator Of Lymphocyte Activitymentioning

confidence: 99%

State of the art paper T lymphocytes as a target of histamine action

Kmiecik

Otocka-Kmiecik²,

Górska-Ciebiada³

et al. 2012

aoms

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“…As reported previously, a good secondary antibody response can be obtained with such PBL on condition that histamine-binding suppressor T cells are removed [Z]. The cell fractionation procedure on insolubilized histamine and the culture conditions for PBL have been described [25]. The numbers of direct and indirect plaques were determined following the Cunningham method.…”

Section: Induction Of An In Vitro Plaque-forming Cell (Pfc) Responsementioning

confidence: 99%

The immunomodulatory effect of anti‐Micrococcus luteus antibodies I. Effect on in vitro rabbit T cell functions

et al. 1983

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A range of purified rabbit anti-Micrococcus luteus antibodies (anti-MCAb) were tested for their ability to interfere with a variety of in vitro immune responses. Such antibodies strongly inhibited the secondary IgG antibody response to sheep red blood cells without affecting the IgM response or the proliferative responses to mitogens and antigens. By exposing lymphocyte populations to anti-MCAb, it was found that such reagents exerted a strong mitogenic effect on rabbit T lymphocytes, provided these cells were derived from antigen-activated lymph nodes. This mitogenic effect was also obtained with F(ab')2 fragments of anti-MCAb and with hybridoma-derived anti-MCAb. Collectively, these data indicate that anti-MCAb inhibit the initiation of IgG synthesis possibly through the expansion of immunoregulatory T cell subsets.

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“…Although the mechanisms responsible for autoimmunity are still poorly defined, both functional and numerical defects in the cells actively suppressing autoaggressive lymphocytes are likely candidates (6)(7)(8). A subset of T cells with the potential to suppress B cells, has been recognized by its ability specifically to bind histamine to membrane receptors (H + T cells) (9)(10)(11)(12)(13)(14)(15)(16).…”

Section: Accepted For Publication 21 January I984mentioning

confidence: 99%