Histamine, But Not Leukotriene C4, is an Essential Mediator in Cold Urticaria Wheals

Nuutinen, Pauliina; Harvima, Ilkka T.; Ackermann, Leena

doi:10.2340/00015555-0185

Cited by 16 publications

(13 citation statements)

References 30 publications

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“…Most types of urticaria, including chronic spontaneous urticaria and the majority of inducible urticarias, are mediated primarily by mast cell-derived histamine[20] which reaches very high concentrations due to the poor diffusibility of substances in the dermis. [2122] They are characterized by short-lived wheals ranging from a few millimeters to several centimeters in diameter which are accompanied by severe itching which is usually worse in the evening or night-time.…”

Section: Introductionmentioning

confidence: 99%

Pharmacology of antihistamines

Church

Church²

2013

Indian J Dermatol

152

103

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H1-antihistamines, the mainstay of treatment for urticaria, were developed from anticholinergic drugs more than 70 years ago. They act as inverse agonists rather than antagonists of histamine H1-receptors which are members of the G-protein family. The older first generation H1-antihistamines penetrate readily into the brain to cause sedation, drowsiness, fatigue and impaired concentration and memory causing detrimental effects on learning and examination performance in children and on impairment of the ability of adults to work and drive. Their use should be discouraged. The newer second-generation H1-antihistamines are safer, cause less sedation and are more efficacious. Three drugs widely used for symptomatic relief in urticaria, desloratadine, levocetirizine and fexofenadine are highlighted in this review. Of these levocetirizine and fexofenadine are the most potent in humans in vivo. However, levocetirizine may cause somnolence in susceptible individuals, whereas fexofenadine has a relatively short duration of action and may be required to be given twice daily for all round daily protection. Although desloratadine is less potent, it has the advantages of rarely causing somnolence and having a long duration of action.

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Section: Introductionmentioning

confidence: 99%

Pharmacology of antihistamines

Church

Church²

2013

Indian J Dermatol

152

103

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“…Symptoms are usually limited to coldexposed skin areas, but extensive cold contact may result in generalized symptoms, such as headache, dyspnoea, hypotension and loss of consciousness (5,6). Hives are caused by histamine (7)(8)(9)(10) and other mediators, such as platelet-activating factor (PAF) and cytokines released from activated mast-cells, after exposure to cold triggering factors (1,2,(11)(12)(13)(14)(15)(16). To confirm the diagnosis cold stimulation standardized tests are mandatory.…”

mentioning

confidence: 99%

Temperature Thresholds in Assessment of the Clinical Course of Acquired Cold Contact Urticaria: A Prospective Observational One-year Study

Martínez-Escala

Curto‐Barredo²,

Carnero³

et al. 2015

Acta Derm Venerol

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Cold contact urticaria is the second most common subtype of physical urticaria. Cold stimulation standardized tests are mandatory to confirm the diagnosis. The aim of this study is to define the utility of determining thresholds (critical time and temperature) in assessment of the clinical course of typical acquired cold contact urticaria. Nineteen adult patients (10 women and 9 men; mean age 45 years) were included in the study and the diagnosis was confirmed with the ice-cube test and TempTest 3.0. Patients were treated continuously for 1 year with 20 mg/day rupatadine (anti-H1). Thresholds measurements were made before and after treatment. Improvements in temperature and critical time thresholds were found in the study sample, demonstrating the efficacy of continuous treatment with rupatadine. In most cases association with a clinical improvement was found. We propose an algorithm for the management of acquired cold contact urticaria based on these results.

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“…A pilot study of nettle- Burn injury (132) induced urticaria showed immediate discomfort and stinging pain but marginal histamine release and no leukotriene release (123). The absence of leukotriene release was directly confirmed in cold urticaria using microdialysis samples and indirectly by the absence of a clinical effect of montelukast, a leukotriene antagonist (124). recently, Kring Tannert et al (125) performed an elegant study showing normalisation of histamine release in the skin of patients with cold-test urticaria after successful cold desensitisation but the maintenance of its releasability to codeine treatment.…”

Section: Urticariamentioning

confidence: 96%

Microdialysis of Inflammatory Mediators in the Skin: A Review

Hersini¹,

Melgaard²,

Gazerani³

et al. 2014

Acta Derm Venerol

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Skin microdialysis is an established method for in vivo sample collection from the extracellular fluid space. This method has been extensively used in studies of inflammatory reactions in the skin of animals and humans. Skin microdialysis consists of the implantation of semi-permeable probes into the upper dermis, perfusion with a physiological buffer, and the recovery of the substances that diffused from the skin into the perfusion fluid. Microdialysis allows the simultaneous assessment of the temporal variations of inflammatory mediator release in the skin as well as the monitoring of vascular and sensory functions. By the aid of this technique, potential associations can be found between functional changes and a variety of substances and mediators released at the site of interest. This allows further insights into the possible mechanisms underlying physiological and pathophysiological events in the skin, including cutaneous inflammation. This review provides a comprehensive but not exhaustive review of the use of microdialysis in studies of experimental and clinical inflammatory reactions in the skin in animals and humans.

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Histamine, But Not Leukotriene C4, is an Essential Mediator in Cold Urticaria Wheals

Cited by 16 publications

References 30 publications

Pharmacology of antihistamines

Pharmacology of antihistamines

Temperature Thresholds in Assessment of the Clinical Course of Acquired Cold Contact Urticaria: A Prospective Observational One-year Study

Microdialysis of Inflammatory Mediators in the Skin: A Review

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