Histamine content in human kidneys with hypernephroid carcinoma. Is there a pathophysiological mechanism?

Reimann, H. J.; Tauber, R.; Wendt, P.; Melamed, I; Gebauer, Paul W.; Permanetter, G.; Meyer, H. J.; Halt, Th.; Swoboda, Kathryn J.

doi:10.1007/bf02004706

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…High concentrations of histamine have been reported in various cancers [35][36][37][38]. Patients with colorectal tumors that are infiltrated by histamine secreting cells such as basophils and mast cells have a poor prognosis indicating the importance of histamine in tumor progression [39].…”

Section: Discussionmentioning

confidence: 99%

Effect of Pre-Operative Short Course Famotidine on Tumor Infiltrating Lymphocytes in Colorectal Cancer: A Double Blind, Placebo Controlled, Prospective Randomized Study

Kapoor

Pal

Sahni

et al. 2005

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

Effect of Pre-Operative Short Course Famotidine on Tumor Infiltrating Lymphocytes in Colorectal Cancer: A Double Blind, Placebo Controlled, Prospective Randomized Study

Kapoor

Pal

Sahni

et al. 2005

Journal of Surgical Research

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Histamine content, diamine oxidase activity and histamine methyltransferase activity in human tissues: Fact or fictions?

et al. 1984

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To understand the role of histamine in the aetiology and pathogenesis of human diseases reliable data are urgently needed for the histamine content and for the activities of histamine-forming and -inactivating enzymes in human tissues. In order to make a substantial progress toward this aim a tissue-sampling programme during surgical interventions was carefully conceived and conducted. From March 1982 until January 1983 106 tissue specimens were taken from 56 patients who underwent surgery. Only healthy tissues, not injured or oedematous, and without adherent structures were taken by only one surgeon who was interested in this research and experienced in tissue preparation procedures in biochemistry. The times of 'warm' ischaemia during the operative procedures were visually estimated, the times between resection of the organs or specimens and deep-freezing of the tissues were precisely recorded. Compared to previous work in the literature and especially to our own work using the same assays for determination higher histamine contents were found in this study in most of the tissues, in particular in the gastrointestinal tract. Also the diamine oxidase activities were considerably higher in many organs, e.g. 3-4 times higher in the gastrointestinal tract when compared with those in publications of our group who used always the same analytical test. However, the histamine methyltransferase activities in this study were not at variance to those determined in previous investigations. Many of them were reported in this communication for the first time. Since the methods for histamine determination and those for measuring enzymic activities were not different in this study and in previous communications of our group we are convinced that the optimized tissue-sampling and -preparation techniques were responsible for the higher values in this communication. But the problem of the 'warm' ischaemia period could not be solved by sample-taking procedures of this type during operations. There are good reasons to prefer biopsy specimens for the analysis of histamine storage and metabolism in human tissues in health and disease, but - unfortunately - they are not always available.

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Histamine H1 receptor antagonists inhibit autoregulation of renal blood flow in the dog.

Banks¹,

Inscho²,

Jacobson³

1984

Circulation Research

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Histamine H1 and H2 receptors are present in the canine renal circulation. We have examined the effects of H1 and H2 receptor antagonists on autoregulation of renal blood flow in the dog. Renal arterial pressure was reduced in a step-wise fashion to 80 mm Hg by means of an adjustable aortic clamp positioned above the left renal artery. Infusion of H2 antagonists, cimetidine or ranitidine, into the left renal artery at 10(-5) mol/min had no effect on autoregulation of renal blood flow or on the reactive hyperemia that occurred when the aortic constriction was released. By contrast, intrarenal infusion of 10(-5) mol/min chlorpheniramine, an H1 receptor antagonist, reversibly attenuated reactive hyperemia and the ability of the kidney to autoregulate renal blood flow. Similar results were obtained with other, chemically dissimilar H1 antagonists (terfenadine, diphenhydramine, and pyrilamine). The effects of chlorpheniramine on autoregulation of glomerular filtration rate also were evaluated. Before chlorpheniramine was infused (at 10(-5) mol/min), the reduction of renal arterial pressure to 90 mm Hg had no effect on the glomerular filtration rate, whereas, during infusion of the H1 antagonist, the glomerular filtration rate fell significantly when renal arterial pressure was reduced to 90 mm Hg. Infusion of histamine (1 microgram/kg per min) with increasing amounts of cimetidine, chlorpheniramine, diphenhydramine, or pyrilamine resulted in virtually identical dose-dependent decreases in histamine-induced renal vasodilation. However, even with 10(-5) mol/min cimetidine or 10(-5) mol/min chlorpheniramine, diphenhydramine, or pyrilamine, a significant histamine-induced renal vasodilation was observed.(ABSTRACT TRUNCATED AT 250 WORDS)

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Histamine content in human kidneys with hypernephroid carcinoma. Is there a pathophysiological mechanism?

Cited by 3 publications

References 5 publications

Effect of Pre-Operative Short Course Famotidine on Tumor Infiltrating Lymphocytes in Colorectal Cancer: A Double Blind, Placebo Controlled, Prospective Randomized Study

Effect of Pre-Operative Short Course Famotidine on Tumor Infiltrating Lymphocytes in Colorectal Cancer: A Double Blind, Placebo Controlled, Prospective Randomized Study

Histamine content, diamine oxidase activity and histamine methyltransferase activity in human tissues: Fact or fictions?

Histamine H1 receptor antagonists inhibit autoregulation of renal blood flow in the dog.

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