Histamine content in lymph nodes from patients with malignant lymphomas

Tumor formation and antitumor immunity; the overlooked significance of histamine

“…The median levels of HA were determined in lymph nodes of patients with malignant lymphomas, HD, or NHL, and in all cases, the values were higher than in controls. In patients with NHL, the levels of HA showed a dependence on the grade of malignancy, as they were significantly higher in those classified as high-grade-malignant [66]. Immunostaining and ELISA also confirmed the presence of HA in the cytoplasm of ALL cells.…”

Roles of histamine on the expression of aldehyde dehydrogenase 1 in endometrioid adenocarcinoma cell line

“…In addition, histamine induces the proliferation and differentiation of hematopoietic and neural stem cells [7][8][9]. Since the first report in 1984 showing that the inhibition of the histamine-synthesizing enzyme, HDC which catalyzes the biosynthesis of histamine from histidine, resulted in antitumoral effects on experimental tumors in rodents [46], a large body of experimental evidence has supported the critical role of HDC and histamine in tumor development and progression [5,6,[12][13][14][15][16][17]. In diverse human tumors, histamine concentration is higher than that of surrounding normal tissue [15,17,47].…”

“…In diverse human tumors, histamine concentration is higher than that of surrounding normal tissue [15,17,47]. Moreover, histamine has been reported to be involved in cancer cell proliferation, migration and invasion, tumor microenvironment, and immune system responses in diverse human tumors including melanoma, lymphomas, leukemia, colon, gynecologic and breast cancer, as well as in experimental tumors [12][13][14][15][16][17]. Similar with these reports, our findings suggested that histamine appeared to play a tumorigenic role in endometrioid adenocarcinoma cell line.…”

“…Of particular note is that histamine has been reported to induce the proliferation and differentiation of hematopoietic and neural stem cells [7][8][9]. Moreover, high histamine biosynthesis and content have been indicated in human tumors including melanoma, lymphoma, leukemia, colon, gynecologic, and breast cancer, as well as in experimental tumors [12][13][14][15][16][17]. Histamine is considered to play a critical role in cancer cell proliferation, migration, and invasion, the tumor microenvironment and immune system responses [5,6,[12][13][14][15][16][17].…”

Histamine Receptors as Potential Therapeutic Targets for Cancer Drug Development

“…The histamine levels were determined in lymph nodes of patients with malignant lymphomas, Hodking´s disease (HD) or non-Hodking lymphomas (NHL), and in all cases the values were higher than in controls. In patients with NHL, these levels showed www.intechopen.com dependence on the grade of malignancy as they found to be significantly higher in those classified as high-grade malignant (Belcheva & Mishkova, 1995). Immunostaining and ELISA method also confirmed the presence of histamine in the cytoplasm of acute lymphocytic leukaemia (ALL) cells, and H 1 R antihistamines inhibited their clonogenic growth.…”