Histamine evokes excitatory response of neurons in the cerebellar dentate nucleus via H2 receptors

Qin, Yong-Ting; Ma, Songhua; Zhuang, Qian-Xing; Qiu, Yihua; Li, Bing; Peng, Yu‐Ping; Wang, Jianjun

doi:10.1016/j.neulet.2011.05.241

Cited by 8 publications

(7 citation statements)

References 18 publications

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“…Statistical analysis showed a difference between testing days (OF1 and OF2) for the time that the mice ceived SAL (Figure 1). planning and initiating of movement [26]. In the present study, when we used an H4 agonist microinjected in the cerebellar vermis in mice, there was a deficit in the consolidation of motor learning in the animals in the rotarod test.…”

Section: Open Fieldmentioning

confidence: 46%

Intracerebellar Microinjection of an H4 Agonist Impairs Memory Consolidation in Open Field and Rotarod Tasks in Mice

C.E.M.¹,

Guilherme²,

Serafim³

et al. 2021

Int J Cogn Behav

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The cerebellum is known to participate in motor functions, but the role of the histaminergic system, and specifically the H4 receptors, in its functions is still unclear. In the present study, we investigated the effects of intravermis microinjections of an H4 receptor agonist (VUF-8430) on mice behavior undergoing a rotarod (Experiment 1) and open field (Experiment 2) test. The cerebellar vermis of male mice was implanted with a single guide cannula. All experiments were performed on two consecutive days: exposure (R1-first day in the rotarod test or OF1-first day in the open field test), followed by re-exposure (R2-second day in the rotarod test or OF2-second day in the open field test) 24 h later. The animals received saline (SAL) or VUF (0.15 nmol; 0.49 nmol; 1.48 nmol/0.1 μl) administered intravermis immediately after R1 or OF1. The data were analyzed using one-way ANOVA and Duncan's post hoc test. In Experiment 1, the drug led to a decrease of consolidation latency for the VUF 0.49 and VUF 1.48 groups compared to the control SAL group in R2. In Experiment 2, the VUF 1.48 group had a significant increase in freezing time in the open field in OF2 compared to OF1. These results suggests that the H4 agonist VUF 8430 at its highest dose (1.48 nmol) impairs memory consolidation in open field and rotarod tasks in mice (Graphical abstract).

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Section: Open Fieldmentioning

confidence: 46%

Intracerebellar Microinjection of an H4 Agonist Impairs Memory Consolidation in Open Field and Rotarod Tasks in Mice

C.E.M.¹,

Guilherme²,

Serafim³

et al. 2021

Int J Cogn Behav

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“…H2R mainly mediates the neuronal excitability elicited by histamine. Histamine induced excitatory response in globus pallidus neurons and cerebellar dentate nucleus neurons, as well as cerebellar Purkinje cells through H2 receptors (Chen, Wang, Yung, Chan & Chow, 2005;Qin et al, 2011;Tian, Wen, Li, Zuo & Wang, 2000), which linked to intracellular G-protein-adenylate cyclase (AC)-PKA signaling pathway (Chen, Wang, Yung, Chan & Chow, 2005). Additionally, histamine elicits excitatory response in the lateral vestibular nucleus neurons in rats, which is co-mediated by the H2R linked-hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and K + channels (Li et al, 2016).…”

Section: H2r and Neural Excitabilitymentioning

confidence: 99%

Central Histaminergic Signaling, Neural Excitability and Epilepsy

Yang

Wang

Chen

2020

Preprint

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Epilepsy is a common neurological disorder characterized by repeated and spontaneous epileptic seizures, which is not well controlled by current medication. Traditional theory supports that epilepsy results from the imbalance of excitatory glutamate neurons and inhibitory GABAergic neurons. Recently, shreds of evidence from available clinical and preclinical researches suggest that histamine in the central nervous system plays an important role in the modulation of neural excitability and pathogenesis of epilepsy. Many histamine receptor ligands show positive response in animal epilepsy models, among which the H3R antagonist pitolisant even has shown a good anti-epileptic effect in clinical trials. New insights are focusing on the potential action of histamine receptors to control and treat epilepsy. This review summarizes the findings from animal and clinical researches on the role of brain histamine and histamine receptor in epilepsy. Importantly, we further provide perspectives on some possible research directions for future studies.

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“…The selected nuclear neurons give rise to the cerebellohypothalamic fibers, the closing section of the ascending limb. It is interesting that neurons in all the cerebellar nuclei received histaminergic terminals from collaterals of the hypothalamocerebellar fibers [18][19][20]. In practice, histamine would be important both in regulating some intrinsic circuits of the cortex, from which activity the efferents destined to the nuclei arise, and in regulating the activity of some nuclear neurons, at the origin of efferents to the hypothalamus.…”

Section: Volume 2 -Issuementioning

confidence: 99%

Isolated and Recurrent Peripheral Facial Palsy Revealing Primary Sjogren’s Syndrome

Bouomrani

Guermazi

Yahyaoui

et al. 2019

OJNBD

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The distribution of histamine in the human cerebellar cortex was studied by light microscope immunohistochemistry using a rabbit polyclonal antibody anti-histamine. In all layers of the cerebellar cortex, were revealed punctate immunoreactive elements related to putative histaminergic nerve terminals. These findings provide insights into the existence of a histaminergic system in the human cerebellar cortex, presumably involved in the cerebrocerebellar circuit, the feedback circuit through which the cerebellum is widely connected with the neocortex and the hypothalamus and intervene in the regulation of motor and non-motor functions.

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Histamine evokes excitatory response of neurons in the cerebellar dentate nucleus via H2 receptors

Cited by 8 publications

References 18 publications

Intracerebellar Microinjection of an H4 Agonist Impairs Memory Consolidation in Open Field and Rotarod Tasks in Mice

Intracerebellar Microinjection of an H4 Agonist Impairs Memory Consolidation in Open Field and Rotarod Tasks in Mice

Central Histaminergic Signaling, Neural Excitability and Epilepsy

Isolated and Recurrent Peripheral Facial Palsy Revealing Primary Sjogren’s Syndrome

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