Histamine H<sub>3</sub> receptor‐mediated inhibition of noradrenaline release in the human brain

Schlicker, Eberhard; Werthwein, Sven; Zentner, Josef

doi:10.1111/j.1472-8206.1999.tb00330.x

Cited by 37 publications

(13 citation statements)

References 6 publications

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“…In addition, to regulating the release of histamine, H3 receptor activation has been found to inhibit the release of many other neurotransmitters, including acetylcholine, glutamate, GABA, 5-HT, noradrenaline and dopamine (Blandina et al, 1996;Brown and Reymann, 1996;Schlicker et al, 1999;Jang et al, 2001;Fox et al, 2005;Medhurst et al, 2007). As with the effect of H3 receptors on histamine release, there appear to be regional differences in the regulation of other neurotransmitters, although this has been less systematically investigated.…”

Section: The H 3 Receptor and Its Interaction With Dopaminementioning

confidence: 99%

Histamine H₃ receptors, the complex interaction with dopamine and its implications for addiction

Ellenbroek

2013

British J Pharmacology

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Histamine H3 receptors are best known as presynaptic receptors inhibiting the release of histamine, as well as other neurotransmitters including acetylcholine and dopamine. However, in the dorsal and ventral striatum, the vast majority of H3 receptors are actually located postsynaptically on medium sized spiny output neurons. These cells also contain large numbers of dopamine (D1 and D2) receptors and it has been shown that H3 receptors form heterodimers with both D1 and D2 receptors. Thus, the anatomical localization of H3 receptors suggests a complex interaction that could both enhance and inhibit dopaminergic neurotransmission. Dopamine, especially within the striatal complex, plays a crucial role in the development of addiction, both in the initial reinforcing effects of drugs of abuse, as well as in maintenance, relapse and reinstatement of drug taking behaviour. It is, therefore, conceivable that H3 receptors can moderate the development and maintenance of drug addiction. In the present review, we appraise the current literature on the involvement of H3 receptors in drug addiction and try to explain these data within a theoretical framework, as well as provide suggestions for further research. Linked Articles This article is part of a themed issue on Histamine Pharmacology Update. To view the other articles in this issue visit

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Section: The H 3 Receptor and Its Interaction With Dopaminementioning

confidence: 99%

Histamine H₃ receptors, the complex interaction with dopamine and its implications for addiction

Ellenbroek

2013

British J Pharmacology

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“…This autoinhibition by H 3 receptor agonists [e.g., (R)-a-methylhistamine; 33] and its removal by H 3 receptor antagonists/partial agonists can be demonstrated in recordings from TMN neurons. As presynaptic heteroreceptors, H 3 receptors control the release of several other transmitters, including biogenic amines (Schlicker et al, 1994(Schlicker et al, , 1999, acetylcholine (Blandina et al, 1996;Arrang, 2007), GABA (Jang et al, 2001), and glutamate; field potentials evoked by stimulation of glutamate fiber bundles, e.g., in hippocampus or striatum, show a marked decrease in the presence of an H 3 receptor agonist (Brown and Haas, 1999;Doreulee et al, 2001) (Fig. 12).…”

Section: Functionmentioning

confidence: 99%

International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors

et al. 2015

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“…2), as well as histamine synthesis and release from varicosities (Arrang et al, 1987). As presynaptic heteroreceptors H 3 receptors control the release of a variety of other neurotransmitters involved in sleep-waking regulation, including biogenic amines (Schlicker et al, 1999), acetylcholine (Passani et al, 2004), glutamate (Doreulee et al, 2001), and GABA and peptides (Pillot et al, 2002) (Fig. 1).…”

Section: Histamine H 3 Receptorsmentioning

confidence: 99%

“…Similar presynaptic interactions occur ubiquitously in the central nervous system e.g., at catecholaminergic, cholinergic, serotonergic, glutamatergic, GABAergic, and peptidergic terminal axons. Direct measurements of these phenomena at single cells or even single synapses are difficult but they have been extensively studied at more macroscopic levels with push-pull, microdialysis, or superfusion studies (Schlicker et al, 1999).…”

Section: Autoreceptors and Heteroreceptorsmentioning

confidence: 99%

Histamine H₃ Receptors and Sleep-Wake Regulation

Lin

Sergeeva²,

Haas³

2010

J Pharmacol Exp Ther

121

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The histaminergic system fulfills a major role in the maintenance of waking. Histaminergic neurons are located exclusively in the posterior hypothalamus from where they project to most areas of the central nervous system. The histamine H 3 receptors are autoreceptors damping histamine synthesis, the firing frequency of histamine neurons, and the release of histamine from axonal varicosities. It is noteworthy that this action also extends to heteroreceptors on the axons of most other neurotransmitter systems, allowing a powerful control over multiple homeostatic functions. The particular properties and locations of histamine H 3 receptors provide quite favorable attributes to make this a most promising target for pharmacological interventions of sleep and waking disorders associated with narcolepsy, Parkinson's disease, and other neuropsychiatric indications. Sleep and WakingWakefulness and consciousness depend on perturbation of intrinsic cortical activity that is achieved through ascending activating systems taking a ventral route, the ascending reticular activating system of Moruzzi and Magoun, and a dorsal route whose main station is the hypothalamus. Both pathways send direct projections to the cortex and indirect ones through the thalamus, the door to perception of sensory input. Both waking and paradoxical sleep (REM) are conscious states and need activation by subcortical structures, although in different ways.Cholinergic neurons of the brainstem and the basal forebrain discharge tonically during both wakefulness and paradoxical sleep, can directly excite cortical neurons, and facilitate the thalamo-cortical transmission by inhibiting the thalamic reticular sleep-onset generator. Brainstem and basal forebrain cholinergic neurons are excited by glutamatergic, noradrenergic, and histaminergic neurons; they are particularly important in cortical electroencephalogram arousal, but do not seem to be essential for the waking state (Szymusiak and McGinty, 1986;Lin, 2000).Monoaminergic ascending projections containing catecholamines and serotonin are involved in sleep-waking regulation and the pathophysiology of major psychiatric disorders, schizophrenia, and depression, all of which include disturbance in sleep-waking. Inhibition of catecholamine synthesis decreases waking, and psychostimulants, such as amphetamine, increase waking through accumulation of catecholamines. A lesion of the serotonergic dorsal raphe causes insomnia. These aminergic systems mediate different behavioral expressions during waking, activate immediate early genes, and facilitate locomotion, perception, and cognition (reviewed in Jones, 2005).

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Histamine H₃ receptor‐mediated inhibition of noradrenaline release in the human brain

Abstract: Stimulation-evoked 3H-noradrenaline release in human cerebrocortical slices was inhibited by histamine (in a manner sensitive to clobenpropit) and by imetit, suggesting H3 receptor-mediated inhibition of noradrenaline release in human brain.

Cited by 37 publications

References 6 publications

Histamine H₃ receptors, the complex interaction with dopamine and its implications for addiction

Histamine H₃ receptors, the complex interaction with dopamine and its implications for addiction

International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors

Histamine H₃ Receptors and Sleep-Wake Regulation

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Histamine H3 receptor‐mediated inhibition of noradrenaline release in the human brain

Abstract: Stimulation-evoked 3H-noradrenaline release in human cerebrocortical slices was inhibited by histamine (in a manner sensitive to clobenpropit) and by imetit, suggesting H3 receptor-mediated inhibition of noradrenaline release in human brain.

Cited by 37 publications

References 6 publications

Histamine H3 receptors, the complex interaction with dopamine and its implications for addiction

Histamine H3 receptors, the complex interaction with dopamine and its implications for addiction

International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors

Histamine H3 Receptors and Sleep-Wake Regulation

Contact Info

Product

Resources

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Histamine H₃ receptor‐mediated inhibition of noradrenaline release in the human brain

Histamine H₃ receptors, the complex interaction with dopamine and its implications for addiction

Histamine H₃ receptors, the complex interaction with dopamine and its implications for addiction

Histamine H₃ Receptors and Sleep-Wake Regulation