Histamine H1 receptors are expressed in mouse and frog semicircular canal sensory epithelia

Botta, Laura; Tritto, Simona; Perin, Paola; Laforenza, Umberto; Gastaldi, Giulia; Zampini, Valeria; Zucca, G; Valli, Stefano; Masetto, Sergio; Valli, Paolo

doi:10.1097/wnr.0b013e3282f76151

Cited by 8 publications

(4 citation statements)

References 18 publications

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“…at the afferent vestibular nerve, since H3 antagonists were still effective when the synapse was blocked by a high Mg 2+ /low Ca 2+ solution [ 11 ]. This hypothesis is consistent with the present results, and also with a recent study showing no evidence for H3 receptors expression by vestibular hair cells [ 12 ].…”

Section: Discussionsupporting

confidence: 94%

“…On the other hand, experiments performed on amphibian semicircular canals have shown that H1 and H3 receptor ligands affect the sensory input recorded from the afferent vestibular neurons [ 9 - 11 ], indicating a possible peripheral site of action for these drugs. Consonant with the latter studies, we recently reported that H1 receptors are expressed in frog and mouse hair cells [ 12 ].…”

Section: Introductionmentioning

confidence: 90%

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Calyx and dimorphic neurons of mouse Scarpa's ganglion express histamine H3 receptors

et al. 2009

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Background: Histamine-related drugs are commonly used in the treatment of vertigo and related vestibular disorders. The site of action of these drugs however has not been elucidated yet. Recent works on amphibians showed that histamine H3 receptor antagonists, e.g. betahistine, inhibit the afferent discharge recorded from the vestibular nerve. To assess the expression of H3 histamine receptors in vestibular neurons, we performed mRNA RT-PCR and immunofluorescence experiments in mouse Scarpa's ganglia.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 90%

Calyx and dimorphic neurons of mouse Scarpa's ganglion express histamine H3 receptors

et al. 2009

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“…Studies using RT-PCR and immunoblotting and immunocytochemical experiments in frog and mouse semicircular canal sensory epithelia showed that both frog and mouse vestibular epithelia express H 1 receptors, although no clear evidence for H 3 receptor expression in hair cells was found [19]. However, RT-PCR analysis showed the presence of H 3 receptor mRNA in mouse vestibular ganglia, and H 3 protein expression was found in vestibular neurons characterized by large and round soma, which showed positive staining for calretinin and calbindin [153].…”

Section: Drugs With Effects On Neurotransmitters and Neuromodulator Rmentioning

confidence: 99%

Neuropharmacology of Vestibular System Disorders

Soto¹,

Vega²

2010

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This work reviews the neuropharmacology of the vestibular system, with an emphasis on the mechanism of action of drugs used in the treatment of vestibular disorders. Otolaryngologists are confronted with a rapidly changing field in which advances in the knowledge of ionic channel function and synaptic transmission mechanisms have led to the development of new scientific models for the understanding of vestibular dysfunction and its management. In particular, there have been recent advances in our knowledge of the fundamental mechanisms of vestibular system function and drug mechanisms of action. In this work, drugs acting on vestibular system have been grouped into two main categories according to their primary mechanisms of action: those with effects on neurotransmitters and neuromodulator receptors and those that act on voltage-gated ion channels. Particular attention is given in this review to drugs that may provide additional insight into the pathophysiology of vestibular diseases. A critical review of the pharmacology and highlights of the major advances are discussed in each case.

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“…However, the specific topic of histamine and its signaling in the cochlea or vestibular organs remains scarcely addressed in the literature. A few research teams have identified the expression of histamine receptors in the inner ear of mammals [38][39][40][41]. Additionally, in 2020, our group found mast cells in the inner ear of both rats and mice [42].…”

Section: Introductionmentioning

confidence: 86%

Histamine and Its Receptors in the Mammalian Inner Ear: A Scoping Review

2023

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Background: Histamine is a widely distributed biogenic amine with multiple biological functions mediated by specific receptors that determine the local effects of histamine. This review aims to summarize the published findings on the expression and functional roles of histamine receptors in the inner ear and to identify potential research hotspots and gaps. Methods: A search of the electronic databases PubMed, Web of Science, and OVID EMBASE was performed using the keywords histamine, cochlea*, and inner ear. Of the 181 studies identified, 18 eligible publications were included in the full-text analysis. Results: All four types of histamine receptors were identified in the mammalian inner ear. The functional studies of histamine in the inner ear were mainly in vitro. Clinical evidence suggests that histamine and its receptors may play a role in Ménière’s disease, but the exact mechanism is not fully understood. The effects of histamine on hearing development remain unclear. Conclusions: Existing studies have successfully determined the expression of all four histamine receptors in the mammalian inner ear. However, further functional studies are needed to explore the potential of histamine receptors as targets for the treatment of hearing and balance disorders.

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Histamine H1 receptors are expressed in mouse and frog semicircular canal sensory epithelia

Cited by 8 publications

References 18 publications

Calyx and dimorphic neurons of mouse Scarpa's ganglion express histamine H3 receptors

Calyx and dimorphic neurons of mouse Scarpa's ganglion express histamine H3 receptors

Neuropharmacology of Vestibular System Disorders

Histamine and Its Receptors in the Mammalian Inner Ear: A Scoping Review

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