Histamine H3 antagonist thioperamide dose-dependently enhances memory consolidation and reverses amnesia induced by dizocilpine or scopolamine in a one-trial inhibitory avoidance task in mice

The histamine H3-receptor inverse agonist Pitolisant improves fear memory in mice

“…injections of Pitolisant also enhance consolidation in the contextual fear conditioning paradigm. These results are in agreement with previous experiments demonstrating that the systemic injection of H 3 R inverse agonists facilitates memory consolidation in the passive avoidance task [17], the social memory test [18,19] and the two-trail place recognition task [20]. Together, these data indicate that H 3 R inverse agonists have beneficial effects on different aspects of memory but the neuronal mechanisms underlying these effects are still unclear.…”

“…In addition, other neurotransmitter systems like histamine can facilitate the consolidation of memories [16]. The systemic injection of H 3 R inverse agonists improve consolidation in the inhibitory avoidance test [17], the social memory test [18,19], the two-trail place recognition task [20] and the fear conditioning task [14].…”

The impact of scopolamine pretreatment on 3-iodothyronamine (T1AM) effects on memory and pain in mice

“…One possible candidate is histamine which is endowed with pro-learning and anti-amnestic features (Alleva et al, 2013) (Bernaerts et al, 2004). In addition, since memory retention implies protein synthesis, we can postulate that T1AM, throughout its biotransformation into TA1, is a potent activator of transcriptional activity.…”

The Effects of Clonidine on Discrete-Trial Delayed Spatial Alternation in Two Rat Models of Memory Loss

“…The effects of these antagonists on spatial working memory may be mediated through specific brain regions, such as the medial prefrontal cortex and hippocampus, since microinfusions of NMDA antagonists into either region can disrupt this form of memory (Aura and Riekkinen, 1999;Yoshihara and Ichitani, 2004). To date, the NMDA hypofunction model has been useful in identifying potential memory-enhancing drugs with novel mechanisms of action, such as acetylcholinesterase inhibitors (Csernansky et al, 2005;Keseberg and Schmidt, 1993), agonists at group II metabotropic glutamate receptors , histamine H 3 antagonists (Bernaerts et al, 2004), combinations of a 2 adrenergic/D 2 dopamine receptor antagonists (Marcus et al, 2005), and agonists at a 2 adrenergic receptors (Jentsch and Anzivino, 2004;Marrs et al, 2005;McCann et al, 1987).…”