Histamine, Histamine Antagonists and Cromones

Foreman, J. C.

doi:10.1007/978-3-642-73797-8_18

Cited by 2 publications

(2 citation statements)

References 124 publications

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“…Thus, the present finding that histamine was able to contract ovine airways only after blockade of H 2 -receptors, may reflect the fact that the PCLS were derived from the lung periphery. In addition, the expression of histamine H 2 -receptors in the lungs may also differ depending on the type of lung sample, previous sensitization or infection, frequently leading to down-regulation of H 2 -receptors [47][48][49]. Therefore, H 2 -receptor deficiency in the airways may, at least in part, explain the commonly observed airway hyperreactivity to histamine in asthmatics.…”

Section: Discussionmentioning

confidence: 99%

Comparison Of Airway Responses In Sheep Of Different Age In Precision-cut Lung Slices (PCLS)

Schlepütz

Dassow

Kramer

et al. 2010

C65. Mechanics of the Lung Periphery in Asthma: New Findings

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Background: Animal models should display important characteristics of the human disease. Sheep have been considered particularly useful to study allergic airway responses to common natural antigens causing human asthma. A rationale of this study was to establish a model of ovine precision-cut lung slices (PCLS) for the in vitro measurement of airway responses in newborn and adult animals. We hypothesized that differences in airway reactivity in sheep are present at different ages.

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Section: Discussionmentioning

confidence: 99%

Comparison Of Airway Responses In Sheep Of Different Age In Precision-cut Lung Slices (PCLS)

Schlepütz

Dassow

Kramer

et al. 2010

C65. Mechanics of the Lung Periphery in Asthma: New Findings

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“…The effects of histamine in skin were studied by another English legend in the medical field. Sir Thomas Lewis, whose descriptions of the so-called "triple response" (local reddening, wheal and flare) and of hyperalgesia have recently again been discussed in the context of certain major scientific endeavors (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Histaminergic nerves demonstrated in the skin. A new direct mode of neurogenic inflammation?

Johansson

Virtanen

Hilliges

1995

Experimental Dermatology

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An intradermal administration of histamine into human skin results in a local erythema, edema and often also the sensations of itch and/or pain. These effects have classically been attributed to the presence of histamine-containing mast cells. However, in the present investigation, we report the observation of histamine-immunoreactive nerves in the skin of Sprague-Dawley rats using a new and highly sensitive immunohistochemical approach. These data suggest a more direct route of cutaneous histamine effects, mediated exclusively by the peripheral nervous system. The findings could also give a new basis for explaining histamine-related issues, such as itch.

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Histamine, Histamine Antagonists and Cromones

Cited by 2 publications

References 124 publications

Comparison Of Airway Responses In Sheep Of Different Age In Precision-cut Lung Slices (PCLS)

Comparison Of Airway Responses In Sheep Of Different Age In Precision-cut Lung Slices (PCLS)

Histaminergic nerves demonstrated in the skin. A new direct mode of neurogenic inflammation?

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