Histamine in Anaesthesia and Surgery: Causality Analysis

Histamine content of human osseous tissue: detection and possible source of plasma histamine increase during orthopaedic surgery

“…In 4/20 (20 %) patients bone manipulation led to relevant histamine release [2,4]. Histamine release and different types of operation and different phases of bone repair were not associated.…”

“…Nevertheless, osseous tissue and the different interventions during orthopaedic surgery in our study are unlikely to be the source for histamine release in the intraoperative period. [2,4].…”

“…It can result in anaphylactoid reactions which compromise the function of vital organs [2]. However, these effects of histamine release can be successfully blocked by preoperative administration of H 1 + H 2 -histamine receptor antagonists [1].…”

“…In trauma patients increased plasma histamine levels were observed [3]. Although several surgical procedures cause histamine release [2], no data were available about histamine content of human osseous tissue and a possible association between fracture repair and plasma histamine increases during orthopaedic surgery. The aim of this study was to investigate the histamine content of human osseous tissue and to proof the association of bone repair procedures and plasma histamine changes during orthopaedic surgery.…”

Early and late histamine release induced by albumin, hetastarch and polygeline: some unexpected findings

“…The detrimental consequences of those cardiovascular instabilities, such as silent myocardial infarction, during anaesthesia and their influence on postoperative outcome were demonstrated by Mangano and colleagues [3]. Both experimental and clinical studies have shown that the extent and clinical relevance of histamine release depend on the clinical scenario, concomitant drugs, infusion speed, duration and amount of infusion [4]. Histamine release in general and especially under perioperative conditions can result in anaphylactic/anaphylactoid reactions which can compromise the function of vital organs [4].…”