Histamine Increases Lung Permeability by an H2-Receptor Mechanism

Braude, S.; Royston, David; Coe, Christopher; Barnes, Peter J.

doi:10.1016/s0140-6736(84)90542-7

Cited by 45 publications

(35 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, H 2 receptors may also play a part, as for example in the lung (Braude et al 1984), in porcine proximal colon (Ahrens et al 2003) and in rat pleura (Lo et al 1985). Based on our results, it is evident that the effect of histamine on the electrophysiology of human pleura is mediated mainly via the H 1 histamine receptors, whereas H 2 receptors seem to be involved partially in this effect.…”

Section: Discussionsupporting

confidence: 49%

“…The permeability of other tissues such as bronchial, alveolar, lung (Devalia and Davis, 1991, Braude et al 1984, Vianna and Calixto, 1998 or intestine tissues (Kanwar et al 1994) may be either increased or decreased by histamine. Therefore, depending on the tissue exposed to histamine, permeability may differ, a fact that may explain the discrepancy noted in our results.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of histamine on the electrophysiology of the human parietal pleura

Kouritas

Tsantsaridou

Tepetes

et al. 2011

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Effect of histamine on the electrophysiology of the human parietal pleura

Kouritas

Tsantsaridou

Tepetes

et al. 2011

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

“…Several mechanisms may account for the enhanced bronchial reactivity after allergen provocation. Firstly, disruption of the airway epithelium by cytotoxic mediators released from inflammatory cells (Frigas & Gleich, 1986) or opening of tight junctions between the airway epithelial cells by endogenous histamine released after allergen provocation (Braude et al, 1984), may facilitate the access of various bronchoconstrictor compounds to the airway smooth muscle.…”

Section: Discussionmentioning

confidence: 99%

Contribution of a cholinergic reflex mechanism to allergen‐induced bronchial hyperreactivity in permanently instrumented, unrestrained guinea‐pigs

Santing

Pasman

Olymulder

et al. 1995

British J Pharmacology

View full text Add to dashboard Cite

1 In conscious, permanently instrumented, unrestrained, ovalbumin-sensitized guinea-pigs the development of allergen-induced bronchial hyperreactivity to histamine-and methacholine-inhalation was investigated after the early as well as after the late asthmatic response. 2 The allergen-induced increase in bronchial reactivity to histamine was significantly higher than to methacholine. 3 The muscarinic receptor antagonist, ipratropium bromide (1.0 mM, 3 min inhalation), blocked methacholine-induced bronchoconstriction and caused a significant 1.7 fold inhibition of the histamineinduced bronchoconstriction of control animals. 4 A lower dose of ipratropium bromide (0.1 mM, 3 min inhalation) had no significant effect on histamine-induced bronchoconstriction in control animals, but significantly reduced the allergen-induced increase in bronchial reactivity to histamine between the early and late asthmatic response. At 1.0 mM ipratropium bromide, no further reduction was observed. 5 These results clearly indicate that an exaggerated cholinergic reflex mechanism contributes to allergen-induced bronchial hyperreactivity to histamine.

show abstract

“…A number of workers have stressed a possible role for epithelial tight junctions in the development of chronic bronchitis (Hulbert et al, 1981;Walker et al, 1984), asthma (Devalia et al, 1994;Boucher et al, 1978;Braude et al, 1984), and cystic fibrosis (Boucher et al, 1983;Geddes, 1990). However, owing to the difficulty in obtaining physiological measurements on the function of human airway epithelial tight junctions in vivo, little data to support these hypotheses have been published.…”

Section: Functionmentioning

confidence: 99%