Histamine-mediated regulation of cAMP levels and inositol phosphate metabolism in isolated rabbit retina

Nowak, Jerzy Z.; Sek, B.; Szkiel, B.

doi:10.1007/bf02222219

Cited by 7 publications

(5 citation statements)

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“…We found, however, in human RPE, histamine stimulated PPI turnover of 179 5 10% (n = 5 ) with an ECsO of 20 pM. A nearly identical accumulation (1 80%) was reported with histamine stimulation of PPI metabolism in rabbit retina (Nowak et al, 1989). The histaminergic response in human RPE likely occurred by the HI receptor because mepyramine, a selective HI antagonist, completely blocked histamine-stimulated PPI metabolism.…”

Section: Discussionsupporting

confidence: 68%

“…The histaminergic response in human RPE likely occurred by the HI receptor because mepyramine, a selective HI antagonist, completely blocked histamine-stimulated PPI metabolism. This receptor subtype is present in bovine (Nowak and Maslinski, 1986) and rabbit (Nowak et al, 1989) retina. In a similar pattern in the CNS, HI receptors are linked to CNS inositol lipid turnover, especially in the cerebellum and hypothalamus, whereas cyclic AMP accumulation occurs by the H2 receptor (Fisher and Agranoff, 1986).…”

Section: Discussionmentioning

confidence: 90%

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Receptor‐Coupled Phosphoinositide Hydrolysis in Human Retinal Pigment Epithelium

Feldman

Randolph

Johnston

et al. 1991

Journal of Neurochemistry

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Carbachol and histamine stimulated phosphoinositide (PPI) hydrolysis in cultured human retinal pigment epithelium (RPE), as reflected by an accumulation of 3H-inositol phosphates in the presence of 10 mM Li+. Carbachol increased PPI hydrolysis to greater than 600% of basal with an EC50 of 60 microM; stimulation was linear up to 60 min. This activation likely occurred via the M3 muscarinic cholinergic receptor based on the IC50 values for 4-diphenylacetoxy-N-methylpiperidine methiodide (0.47 nM), pirenzepine (280 nM), and 11-[[2-[(diethylamino)methyl]-1-piperidinyl]-acetyl]-5,11- dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one (1.4 microM). Carbachol-mediated PPI hydrolysis was decreased by 80% in the absence of extracellular Ca2+. Histamine stimulated PPI turnover in a linear manner by 180% with an EC50 of 20 microM by the H1 histaminergic receptor. Serotonin, glutamate, norepinephrine, and dopamine were inactive. In human RPE, the resting cytoplasmic Ca2+ concentration, as determined by fura-2 fluorescence, was 138 +/- 24 nM. On the addition of carbachol, there was a 180% increase in peak intracellular Ca2+; addition of histamine increased intracellular Ca2+ by 187%. These results suggest receptor-mediated, inositol lipid hydrolysis is coupled to intracellular Ca2+ flux in human RPE.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 90%

Receptor‐Coupled Phosphoinositide Hydrolysis in Human Retinal Pigment Epithelium

Feldman

Randolph

Johnston

et al. 1991

Journal of Neurochemistry

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“…However, there is indirect evidence that HR2 and HR3 are also present in mammalian retinas. Histamine inhibits a forskolin-induced increase in cAMP in the rabbit retina via HR2 (Nowak, 1991;Nowak et al, 1989). Histamine also increases a GABA A -mediated chloride current in amacrine cells from rat retinal slices via protein kinase A (PKA; Feigenspan and Bormann, 1994), the signaling pathway typically used by HR2 (Gantz et al, 1991).…”

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confidence: 99%

Histamine receptors in mammalian retinas

Gastinger

Barber

Vardi

et al. 2006

J of Comparative Neurology

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Mammalian retinas are innervated by histaminergic axons that originate from perikarya in the posterior hypothalamus. To identify the targets of these retinopetal axons, we localized histamine receptors (HR) in monkey and rat retinas by light and electron microscopy. In monkeys, puncta containing HR3 were found at the tips of ON-bipolar cell dendrites in cone pedicles and rod spherules, closer to the photoreceptors than the other neurotransmitter receptors. This is the first ultrastructural localization of any histamine receptor and the first direct evidence that HR3 is present on postsynaptic membranes in the central nervous system. In rat retinas, most HR1 were localized to dopaminergic amacrine cells. The differences in histamine receptor localization may reflect the differences in the activity patterns of the two species. Indexing termsretinopetal; centrifugal; bipolar; amacrine; primate; dopamine Vertebrate retinas receive input from the brain via retinopetal axons, and this pathway has important modulatory effects on retinal neurons in birds and fish, the groups that have been studied most intensively. The functions of retinopetal axons in mammalian retinas are not well understood, however (Uchiyama, 1989). Histamine has been localized to retinopetal axons in the guinea pig (Airaksinen and Panula, 1988), monkey (Gastinger et al., 1999), and rat (Gastinger et al., 2001) retinas. These axons originate from perikarya in the tuberomammillary nucleus of the posterior hypothalamus (Manning et al., 1996;Panula et al., 1989). Mast cells, another possible source of histamine, are not present in the retina (Smelser and Silver, 1963). With the identification of the neurotransmitter of these retinopetal axons, it is now possible to predict how these inputs contribute to information processing in mammalian retinas.These retinopetal axons are expected to be active at night in rats and during the day in monkeys. Histaminergic neurons play an important role in the ascending arousal system (Saper et al., 2001), firing at a steady rate during waking and becoming silent during sleep (Steininger et al., 1999;Vanni-Mercier et al., 2003). In rats, a nocturnal species, histaminergic neurons are most active at night, and the rate of histamine release in the posterior hypothalamus is higher at night than during the day (Prast et al., 1992). In macaques, a diurnal species, levels of histamine metabolites in the third ventricular cerebral spinal fluid are higher during the day than at night (Prell et al., 1989).In the central nervous system, histamine acts on three types of G-protein-coupled receptors: histamine receptor 1 (HR1), histamine receptor 2 (HR2) and histamine receptor 3 (HR3). Among these, only HR1 has been characterized previously in mammalian retinas (Nowak, 1993;Sawai et al., 1988). However, there is indirect evidence that HR2 and HR3 are also present in mammalian retinas. Histamine inhibits a forskolin-induced increase in cAMP in the rabbit retina via HR2 (Nowak, 1991;Nowak et al., 1989). Histamine also increa...

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“…Histamine inhibits a forskolin-induced increase in cAMP in rabbit retina via HR2. 66,67 Histamine also increases a GABA A -mediated chloride current in amacrine cells in rat retinas via protein kinase A, a signaling pathway frequently used by HR2. 68,69 If amacrine cells are inhibited more effectively, there would be less tonic inhibition of the ganglion cells and bipolar cells.…”

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confidence: 99%

Retinopetal Axons in Mammals: Emphasis on Histamine and Serotonin

Gastinger

Tian

Horváth

et al. 2006

Current Eye Research

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Since 1892, anatomical studies have demonstrated that the retinas of mammals, including humans, receive input from the brain via axons emerging from the optic nerve. There are only a small number of these retinopetal axons, but their branches in the inner retina are very extensive. More recently, the neurons in the brain stem that give rise to these axons have been localized, and their neurotransmitters have been identified. One set of retinopetal axons arises from perikarya in the posterior hypothalamus and uses histamine, and the other arises from perikarya in the dorsal raphe and uses serotonin. These serotonergic and histaminergic neurons are not specialized to supply the retina; rather, they are a subset of the neurons that project via collaterals to many other targets in the central nervous system, as well. They are components of the ascending arousal system, firing most rapidly when the animal is awake and active. The contributions of these retinopetal axons to vision may be predicted from the known effects of serotonin and histamine on retinal neurons. There is also evidence suggesting that retinopetal axons play a role in the etiology of retinal diseases. Keywordscentrifugal; efferent; histamine; primate; serotonin MORPHOLOGY AND FUNCTIONS OF RETINOPETAL AXONS IN MAMMALSIn mammalian retinas, three types of retinopetal axons have been distinguished by morphological criteria. The first type gives rise to terminals in the outer strata of the inner plexiform layer (IPL). Typically, the axons terminate along the border with the inner nuclear Copyright (Figs. 1A and 1C). Using the Golgi method, axons with this pattern of branching have been identified in dog 1 and chimpanzee 2 retinas. The second type of retinopetal axon is larger in diameter, varicose, and terminates in the outer plexiform layer (OPL). In rats, these axons are labeled with antibodies to serotonin after loading the retina with a related indoleamine, 5,7-dihydroxytryptamine (5,7-DHT). They originate from perikarya in the optic chiasm or the preoptic area of the hypothalamus. 3 Retinopetal axons similar to these are labeled with neurofilament antibodies in the mouse retina. 4 Neurons that project from the anterior hypothalamus to the retina have been identified in a prosimian, 5 but their terminals in the retina have not been described.The third type of retinopetal axon branches extensively in IPL (Fig. 1B). Using the Golgi method, Polyak described axons like these in macaque retinas. 2 They run in the optic fiber layer (OFL), and they give off a nearly vertical branch to the IPL, where they branch extensively in a broad band in the center of the layer. In the mouse retina, axons with a similar branching pattern are labeled with neurofilament antibodies. 4 These axons are also labeled using reduced silver stains in monkey 6,7 and human 8,9 retinas. These studies confirmed and extended Polyak's descriptions, and they also demonstrated clear morphological differences between retinopetal axons and those of ganglion cells with intraretin...

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Histamine-mediated regulation of cAMP levels and inositol phosphate metabolism in isolated rabbit retina

Cited by 7 publications

References 8 publications

Receptor‐Coupled Phosphoinositide Hydrolysis in Human Retinal Pigment Epithelium

Receptor‐Coupled Phosphoinositide Hydrolysis in Human Retinal Pigment Epithelium

Histamine receptors in mammalian retinas

Retinopetal Axons in Mammals: Emphasis on Histamine and Serotonin

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