Histamine, Metabolic Remodelling and Angiogenesis: A Systems Level Approach

Moya‐García, Aurelio A.; Pino-Ángeles, Almudena; Sánchez‐Jiménez, Francisca; Urdiales, José Luis; Medina, Miguel Ángel

doi:10.3390/biom11030415

Cited by 18 publications

(8 citation statements)

References 118 publications

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“…Histamine has previously been identified as one of the factors of tumorigenesis across many types of cancers because of its roles in immune responses, cell proliferations, angiogenesis, etc. [ 8 , 17 , 22 , 24 ]. Therefore, the matching results reinforce the validity of our experiment.…”

Section: Discussionmentioning

confidence: 99%

Spatial metabolomics on liver cirrhosis to hepatocellular carcinoma progression

Wang

et al. 2022

Cancer Cell Int

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Background Hepatocellular carcinoma (HCC) is one of the deadliest cancers and is mainly developed from chronic liver diseases such as hepatitis-B infection-associated liver cirrhosis (LC). The progression from LC to HCC makes the detection of diagnostic biomarkers to be challenging. Hence, there have been constant efforts to improve on identifying the critical and predictive changes accompanying the disease progression. Methods In this study, we looked to using the mass spectrometry mediated spatial metabolomics technique to simultaneous examine hundreds of metabolites in an untargeted fashion. Additionally, metabolic profiles were compared between six subregions within the HCC tissue to collect spatial information. Results Through those metabolites, altered metabolic pathways in LC and HCC were identified. Specifically, the amino acid metabolisms and the glycerophospholipid metabolisms experienced the most changes. Many of the altered metabolites and metabolic pathways were able to be connected through the urea cycle. Conclusions The identification of the key metabolites and pathways can expand our knowledge on HCC metabolic reprogramming and help us exam potential biomarkers for earlier detection of the malignant disease progression.

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Section: Discussionmentioning

confidence: 99%

Spatial metabolomics on liver cirrhosis to hepatocellular carcinoma progression

Wang

et al. 2022

Cancer Cell Int

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“…The changes reported here could be attributed to the indirect effect of chlorpheniramine on H 1 Rs in the placenta, where it has an angiogenic function ( Moya-García et al, 2021 ), and H 1 R blockade may thus lead to negative consequences on fetoplacental circulation. However, the results reported here, together with the effect of HA and chlorpheniramine on neurogenesis in vivo and in vitro reported previously ( Molina-Hernández and Velasco, 2008 ; Molina-Hernández et al, 2013 ; Solís et al, 2017 ), support a direct effect on brain development.…”

Section: Discussionmentioning

confidence: 83%

Long-Term Functional and Cytoarchitectonic Effects of the Systemic Administration of the Histamine H1 Receptor Antagonist/Inverse Agonist Chlorpheniramine During Gestation in the Rat Offspring Primary Motor Cortex

et al. 2022

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The transient histaminergic system is among the first neurotransmitter systems to appear during brain development in the rat mesencephalon/rhombencephalon. Histamine increases FOXP2-positive deep-layer neuron differentiation of cortical neural stem cells through H1 receptor activation in vitro. The in utero or systemic administration of chlorpheniramine (H1 receptor antagonist/inverse agonist) during deep-layer cortical neurogenesis decreases FOXP2 neurons in the developing cortex, and H1R- or histidine decarboxylase-knockout mice show impairment in learning and memory, wakefulness and nociception, functions modulated by the cerebral cortex. Due to the role of H1R in cortical neural stem cell neurogenesis, the purpose of this study was to evaluate the postnatal impact of the systemic administration of chlorpheniramine during deep-layer cortical neuron differentiation (E12–14) in the primary motor cortex (M1) of neonates (P0) and 21-day-old pups (P21). Chlorpheniramine or vehicle were systemically administered (5 mg/kg, i.p.) to pregnant Wistar rats at gestational days 12–14, and the expression and distribution of deep- (FOXP2 and TBR1) and superficial-layer (SATB2) neuronal cortical markers were analyzed in neonates from both groups. The qRT-PCR analysis revealed a reduction in the expression of Satb2 and FoxP2. However, Western blot and immunofluorescence showed increased protein levels in the chlorpheniramine-treated group. In P21 pups, the three markers showed impaired distribution and increased immunofluorescence in the experimental group. The Sholl analysis evidenced altered dendritic arborization of deep-layer neurons, with lower excitability in response to histamine, as evaluated by whole-cell patch-clamp recording, as well as diminished depolarization-evoked [3H]-glutamate release from striatal slices. Overall, these results suggest long-lasting effects of blocking H1Rs during early neurogenesis that may impact the pathways involved in voluntary motor activity and cognition.

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“…Histamine‐induced angiogenesis via H1 and H2 receptors in vivo was subsequently verified in the mouse (56). Also, histamine synergistically promotes bFGF‐induced angiogenesis by enhancing VEGF‐A production via H1 receptor in human endothelial cells in vitro (57,58).…”

Section: Triad Tissue Response To Mast Cell Secretion In Vivomentioning

confidence: 99%

Do mast cells contribute to the continued survival of vertebrates?

Norrby

2022

APMIS

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This study is an attempt to shed light on why the connective tissue mast cell (MC) is preserved in all species with a blood circulatory system, i.e., the vertebrates since >500 million years, which suggests that the MC performs as yet not understood indispensible life-promoting actions. The literature survey focuses on data in published papers on MC functions in immunological and nonimmunological reactions, host protection, pregnancy, inflammation, and wound healing. All data are thus accessible to the reader. The MC is a secretory cell with a unique mediator profile. A distinctive role for MCs is defined not only by their extensive mediator composition but also by their prominent ability to affect the vasculature to expedite selective cell recruitment and permeability changes and to set the stage for an appropriate acquired response. MCs, harboring a wide range of surface membrane receptors, are activated by the major female sex hormones as well as by diverse potentially adverse stimuli. MC activation/degranulation creates a presumably unique triad tissue response in physiological and pathological situations alike: extracellular matrix degradation and tissue remodeling, de novo cell proliferation, and de novo angiogenesis. As shown in the literature, MCactivation is crucial for successful female reproduction in the mouse, implying one of possibly several yet unidentified physiological roles of MCs. Moreover, the activated MC aids newborns to survive to reproductive age owing to its key beneficial actions in inflammation and wound healing. Thus, a not previously described life-perpetuating loop spanning generations are apparently formed, which, hypothetically, could contribute to the continued survival of the vertebrates.

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Histamine, Metabolic Remodelling and Angiogenesis: A Systems Level Approach

Cited by 18 publications

References 118 publications

Spatial metabolomics on liver cirrhosis to hepatocellular carcinoma progression

Spatial metabolomics on liver cirrhosis to hepatocellular carcinoma progression

Long-Term Functional and Cytoarchitectonic Effects of the Systemic Administration of the Histamine H1 Receptor Antagonist/Inverse Agonist Chlorpheniramine During Gestation in the Rat Offspring Primary Motor Cortex

Do mast cells contribute to the continued survival of vertebrates?

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