Histamine, neutrophil chemotactic factor and circulating basophil levels following exercise in asthmatic and control subjects

Morgan, D. J. R.; Phillips, Melissa; Moodley, I.; Elliott, E. V.; Davies, R. Jeremy H.

doi:10.1111/j.1365-2222.1982.tb03296.x

Cited by 21 publications

(8 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some investigators have reported increased levels of histamine and neutrophil chemotactic factors in the serum ofpatients postexercise, and suggest that exercise-induced asthma is due to mediator release from mast cells (9,10,16,17). Other investigators have failed to detect such mediators (11,12,15), while yet others report similar increases after exercise of nonasthmatic individuals (13,14). We feel that our finding of mediator release in the upper respiratory tract supports the hypothesis that mast cell mediator release is involved in exercise-induced asthma.…”

Section: Discussionsupporting

confidence: 79%

“…This condition is experienced by most asthmatic patients, and controversy exists among investigators regarding its pathogenesis. Attempts to establish the involvement of mast cell mediators have led to ambiguous results (9)(10)(11)(12)(13)(14)(15)(16)(17). Recently, low levels of histamine and another mediator, neutrophil chemotactic factor, have been found in the circulation of asthmatic patients when they exercise while breathing cold air (9,10,16,17), but not upon breathing warm and moist air (WMA) (18).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nasal challenge with cold, dry air results in release of inflammatory mediators. Possible mast cell involvement.

et al. 1985

View full text Add to dashboard Cite

The purpose of our study was to assess the effect of cold, dry air (CDA) on the nasal mucosa of selected individuals in relation to the release of inflammatory mediators associated with mast cells. 12 subjects with a history of nasal symptoms of rhinorrhea and congestion upon cold or dry environmental exposure were challenged by nasal breathing of CDA and warm, moist air (WMA). Each subject was tested on two occasions with the order of the challenges reversed. Symptom scores were recorded, and the levels of histamine, prostaglandin (PG) D2, kinins, and 1H1-N-a-tosyl-L-arginine methyl ester (TAME)-esterase activity in nasal lavage fluids were measured.CDA caused a significant increase in mediator levels and in symptom scores as compared to baseline or to WMA. No significant increase in symptom scores or mediators was noted after WMA challenge, with the exception of a marginal increase in kinins. The response to CDA was similar, regardless of challenge order. Changes in mediators correlated with one another, and symptom scores correlated significantly with the levels of histamine, kinins, and PGD2. Five subjects without a history of nasal symptoms on cold air exposure had no change in mediators or symptom scores after CDA or WMA challenge. We conclude that CDA causes the release of inflammatory mediators possibly associated with mast cells and speculate that such a mechanism may be involved in the bronchospasm induced by CDA in asthmatics.

show abstract

Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Nasal challenge with cold, dry air results in release of inflammatory mediators. Possible mast cell involvement.

et al. 1985

View full text Add to dashboard Cite

show abstract

“…However, the mechanism of this difference is not clear. Recently, the role of chemical mediators, such as histamine and neutrophil chemotactic factor, have been emphasized, although their roles remain controversial (Morgan et al 1982;Howarth et al 1984 ; Lee et al 1984 ;Juniper et al 1987 ;Badier et al 1988;Broide et al 1990). This study showed that chlorpheniramine could suppress RIB suggesting that histamine might play an important role in the induction of HIB in sensitized rabbits.…”

Section: Discussionmentioning

confidence: 99%

Eucapnic Hyperventilation-Induced Bronchoconstriction in Rabbits.

Koyama

Ohtsuka

Horie

1992

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

We examined whether eucapnic hyperventilation with dry air produces the bronchoconstriction in anesthetized, non-sensitized rabbits and in ovalbumin sensitized rabbits. Eucapnic hyperventilation challenge with dry air containing 5% COZ at room temperature was performed with 4 non-sensitized and 7 sensitized rabbits by mechanical ventilation for 15 min (120 breaths/min, 7 ml tidal volume/kg body weight). Total lung resistance (RL) and dynamic compliance (Cdyn) were measured before and 0, 5, 15, and 30 min after hyperventilation. In non-sensitized rabbits, RL and Cdyn did not change significantly. However, in sensitized rabbits, RL increased maximally by 48.9%±9.0% at 5 min, and then decreased to the baseline level at 30 min after challenge. Cdyn decreased maximally by 12.5%± 3.5% at 15 min after challenge. These changes were significantly different from the baselines (p <0.05). Furthermore, to investigate the role of histamine on hyperventilation-induced bronchoconstriction (HIB) in sensitized rabbits, we performed the hyperventilation challenges in 5 sensitized rabbits with the pretreatment of Hl-receptor antagonist (chlorpheniramine, 1 mg/kg, iv.) and found that the maximum increment of RL was suppressed to 24.2%± 7.4% of the control, which was significantly lower than the maximal RL in nontreated sensitized rabbits (p <0.05). We concluded that HIB occurrs only in sensitized rabbits and that histamine may play an important role in the development of HIB in sensitized rabbits.hyperventilation-induced bronchoconstriction ; ovalbumin sensitized rabbits ; chlorpheniramine It has been reported that hyperventilation or exercise challenge can produce bronchoconstriction in some asthmatic subjects. However, the mechanisms of hyperventilation-induced (HIB) and exercise-induced bronchoconstriction (EIB) remain uncertain. Recently, several animal studies were reported clarifying the mechanisms of HIB. coworkers (1988, 1989) demonstrated that HIB in guinea pigs was diminished with humidification of inspired gas, which was reproduced on consecutive identical challenges, and that HIB was independent of

show abstract

“…NCA release has been shown to be initiated by both immunologically specific (i.e. antigen-specific) and non-specific stimuli such as in physical urticarias [28,29] and in exerciseinduced asthma [30,31]. Efl"ects other than, or in addition to, blocking of mast cells might therefore by involved.…”

Section: Discussionmentioning

confidence: 99%

Reduction of increased serum neutrophil chemotactic activity following effective hyposensitization in house dust mite allergy

McHugh

Ewan

1989

Clin Experimental Allergy

View full text Add to dashboard Cite

Changes in the level of serum neutrophil chemotactic activity (S-NCA) were investigated in 20 subjects with allergic rhinitis, with or without asthma, undergoing clinically effective hyposensitization to house dust mite with Pharmalgen Dermatophagoides pteronyssinus. Two control groups were studied: 28 subjects with allergic rhinitis, with or without asthma, receiving placebo injections for 1 yr in a double-blind controlled trial with Pharmalgen D. pteronyssinus (from whom the actively treated group in this study were recruited), and eight non-atopic asymptomatic controls. S-NCA and serum IgE specific to D. pteronyssinus were measured in the subjects before, during (3-6 months) and 12 months after treatment, and once in the non-atopic controls. The mean S-NCA was significantly higher (0.01 greater than P greater than 0.001) in subjects before treatment (mean +/- s.e. = 63.8 +/- 3.6 arbitrary units of migration (AUM] compared with the non-atopic controls (48.5 +/- 3.7 AUM), but had fallen to normal levels after 6 months (46.8 +/- 4.0 AUM) and 12 months treatment (45.2 +/- 3.8 AUM). The levels of S-NCA in the placebo treated group were significantly higher than normal at the start of treatment (69.2 +/- 4.1) and remained raised throughout the 12 months treatment. In the actively treated group, the level of S-NCA had fallen in 18 out of 19 subjects after 12 months immunotherapy, and was unaltered in one. Mean levels of D. pteronyssinus IgE rose during the first 6 months and declined to initial levels by the end of the treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Histamine, neutrophil chemotactic factor and circulating basophil levels following exercise in asthmatic and control subjects

Cited by 21 publications

References 12 publications

Nasal challenge with cold, dry air results in release of inflammatory mediators. Possible mast cell involvement.

Nasal challenge with cold, dry air results in release of inflammatory mediators. Possible mast cell involvement.

Eucapnic Hyperventilation-Induced Bronchoconstriction in Rabbits.

Reduction of increased serum neutrophil chemotactic activity following effective hyposensitization in house dust mite allergy

Contact Info

Product

Resources

About