Histamine Receptors and Signaling

Hegyesi, Hargita; Darvas, Zsuzsanna; Thurmond, Robin L.; Falus, András

doi:10.1007/3-540-26511-2_9

Cited by 5 publications

(5 citation statements)

References 135 publications

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“…H 1 receptors are highly expressed in the endothelium and H 1 receptor antagonists suppress histamine-induced endothelial hyperpermeability (9,18). Histamine binding to H 1 receptors activates phospholipase C, which hydrolyzes phosphatidylinositol 4,5-bisphosphate to produce inositol trisphosphate (IP 3 ) and diacylglycerol (19). IP 3 in turn triggers Ca 2ϩ release from the endoplasmic reticulum (ER) through IP 3 receptors; a key signaling event mediating various physiological and pathophysiological processes of the cell (20 -22).…”

Section: Stim1 and Orai1 In Mediating Camentioning

confidence: 99%

Stromal Interaction Molecule 1 (STIM1) and Orai1 Mediate Histamine-evoked Calcium Entry and Nuclear Factor of Activated T-cells (NFAT) Signaling in Human Umbilical Vein Endothelial Cells

Zhou

Zheng

et al. 2014

Journal of Biological Chemistry

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Background: Histamine is a major inflammatory mediator. Results: H 1 receptor, STIM1, Orai1, and extracellular calcium are indispensable for histamine-induced intracellular calcium mobilization, NFAT nuclear translocation, and IL-8 production in HUVECs. Conclusion: STIM1 and Orai1 mediate histamine-evoked calcium entry and NFAT signaling in endothelial cells. Significance: STIM1 and Orai1 are essential for histamine-induced inflammatory signaling of endothelial cells.

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Section: Stim1 and Orai1 In Mediating Camentioning

confidence: 99%

Stromal Interaction Molecule 1 (STIM1) and Orai1 Mediate Histamine-evoked Calcium Entry and Nuclear Factor of Activated T-cells (NFAT) Signaling in Human Umbilical Vein Endothelial Cells

Zhou

Zheng

et al. 2014

Journal of Biological Chemistry

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“…H1 receptors express in mammalian brain, airway smooth muscle, gastrointestinal tract, genitourinary system, cardiovascular system, adrenal medulla, endothelial and various immune cells. Enhanced expression of H1R was also observed in the nasal mucosa of patients with allergic rhinitis (Hegyesi et al, 2005). H2 receptors are primarily related to gastric acid secretion, while H3 receptor is an autoreceptor that mediates histamine release from the neurons.…”

Section: Discussionmentioning

confidence: 94%

“…Histamine, predominantly stored in mast cells, basophils and enterochromaffin cells, is considered to be one of the most relevant early mediators of the allergic and inflammatory processes. Moreover, histamine is a chemical messenger and aminergic neurotransmitter, playing an important role in a multitude of physiological processes in the central nervous system and peripheral tissues (Hegyesi et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the chemotactic response of eosinophils to other chemokines such as eotaxin can be enhanced by activation of the H4 receptors. An upregulation of adhesion molecules on the surface of eosinophils e such as CD11b/CD18 (Mac-1) and CD54 (ICAM-1) e can also be achieved via H4 receptors (Hegyesi et al, 2005). Thus, H4 receptors mediate a number of important mechanisms to recruit eosinophils to the site of inflammation, such as chemotaxis and expression of adhesion molecules.…”

Section: Discussionmentioning

confidence: 99%

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Histamine H4 receptor expression is elevated in human nasal polyp tissue

Jókúti

Hellinger

et al. 2007

Cell Biology International

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Altered histamine metabolism is thought to be involved in the pathomechanism of nasal polyposis characterized by local eosinophil infiltration. The present study was performed to determine whether histamine receptors play a role in the effect of histamine in nasal polyp tissue. The findings suggest that the expression of H1 and H4 receptors is elevated in polyp tissue (p = 0.045; p < 0.001), while the level of H2 and H3 receptors is not increased significantly. The elevation of H1 and H4 receptors' expression may indicate that the histamine related mechanisms are preferentially mediated through H1 and H4 histamine receptors in the polyp tissue. Simultaneously with increased H4 receptor expression, the concentration of eosinophil cationic protein (ECP) was increased significantly in polyp tissue (p = 0.002). One may speculate that the H4 receptor mediated histamine effects have a role in eosinophil accumulation and activation in inflammatory diseases of the nasal and paranasal sinus mucosa, such as nasal polyposis.

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“…Histamine increases the production of Th2 cytokines, IL-4, IL-5, IL-9 and IL-13, and decreases the production of Th1 cytokines, IL-2 and interferon-gamma [9,11,12]. Mitogen activated protein kinases (MAPKs), control key cellular functions such as differentiation, proliferation, migration and apoptosis, and are involved in a number of disease states including inflammation [14]. MAPKs are composed of three kinases: MAPKKK, MAPKK and MAPK.…”

Section: Introductionmentioning

confidence: 99%