Histamine reduces boron neutron capture therapy‐induced mucositis in an oral precancer model

Hughes, Andrea Monti; Pozzi, E. C. C.; Thorp, Silvia Inés; Curotto, Paula; Medina, Vanina Araceli; Lamas, Diego José Martinel; Rivera, Elena; Garabalino, MA; Farías, R.O.; Gonzalez, S.; Heber, EM; Itoiz, M. E.; Aromando, RF; Nigg, DW; Trivillin, VA; Ae, Schwint

doi:10.1111/odi.12346

Cited by 17 publications

(12 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Estimation of the absolute boron concentrations in normal tissues is important, because alpha-particles from 10 B show large energy transfer and have the potential to cause severe adverse effects in the event of overexposure of the neutron beam [10]. Careful estimation is essential, especially when BNCT is applied for lung or abdominal cancers.…”

Section: Discussionmentioning

confidence: 99%

Practical calculation method to estimate the absolute boron concentration in tissues using 18F-FBPA PET

et al. 2017

View full text Add to dashboard Cite

PurposeThe purpose of this study was to establish a practical method to estimate the absolute boron concentrations in the tissues based on the standardized uptake values (SUVs) after administration of 4-borono-phenylalanine (BPA) using 4-borono-2-18F-fluoro-phenylalanine (18F-FBPA) PET.MethodsRat xenograft models of C6 glioma (n = 7, body weight 241 ± 28.0 g) were used for the study. PET was performed 60 min after intravenous injection of 18F-FBPA (30.5 ± 0.7 MBq). After the PET scanning, BPA-fructose (167.3 ± 18.65 mg/kg) was administered by slow intravenous injection to the same subjects. The rats were killed 60 min after the BPA injection and tissue samples were collected from the major organs and tumors. The absolute boron concentrations (unit: ppm) in the samples were measured by inductively coupled plasma optical emission spectrometry (ICP-OES). The boron concentrations in the tissues/tumors were also estimated from the 18F-FBPA PET images using the following formula: estimated absolute boron concentration (ppm) = 0.0478 × [BPA dose (mg/kg)] × SUV. The measured absolute boron concentrations (mBC) by ICP-OES and the estimated boron concentrations (eBC) from the PET images were compared.ResultsThe percent difference between the mBC and eBC calculated based on the SUVmax was −5.2 ± 21.1% for the blood, −9.4 ± 22.3% for the brain, 1.6 ± 21.3% for the liver, −14.3 ± 16.8% for the spleen, −9.5 ± 27.5% for the pancreas, and 3.4 ± 43.2% for the tumor. Relatively large underestimation was observed for the lung (−48.4 ± 16.2%), small intestine (−37.8 ± 19.3%) and large intestine (−33.9 ± 11.0%), due to the partial volume effect arising from the air or feces contained in these organs. In contrast, relatively large overestimation was observed for the kidney (34.3 ± 29.3%), due to the influence of the high uptake in urine.ConclusionsThe absolute boron concentrations in tissues/tumors can be estimated from the SUVs on 18F-FBPA PET using a practical formula. Caution must be exercised in interpreting the estimated boron concentrations in the lung, small intestine and large intestine, to prevent the adverse effects of overexposure, which could occur due to underestimation by partial volume effect using PET.Electronic supplementary materialThe online version of this article (doi:10.1007/s12149-017-1172-5) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Practical calculation method to estimate the absolute boron concentration in tissues using 18F-FBPA PET

et al. 2017

View full text Add to dashboard Cite

show abstract

“… 3 , 4 , 5 Histamine has also demonstrated efficacy in ameliorating boron neutron capture therapy-induced mucositis in an oral pre-cancer model. 6 …”

mentioning

confidence: 99%

Histamine: a potential cytoprotective agent to improve cancer therapy?

et al. 2015

View full text Add to dashboard Cite

“…It is well known that DMBA-induced squamous cell carcinomas in hamsters have similar morphological, histological and genetic features to human oral squamous cell carcinomas (8). Most of the recent research studies refer to our work as an example of an animal model of oral cancer (8,13,(14)(15)(16)(17)(18)(19)(20). Some studies have used hamster models for applying therapeutic methods such as boron neutron capture therapy (14-16), photoangiolytic treatment (17), photodynamic therapy (18), or chemopreventive compounds, including resveratrol (21), medicinal herbs (22), and phenolic compounds (23) such as apigenin and carnosic acid (19) and olive oil (20).…”

Section: Articles Citing the Foundation Report On The Hamster Model Omentioning

confidence: 93%

The Hamster Model of Sequential Oral Carcinogenesis: An Update

Yapijakis

Kalogera²,

Papakosta

et al. 2019

In Vivo

View full text Add to dashboard Cite

show abstract

Histamine reduces boron neutron capture therapy‐induced mucositis in an oral precancer model

Cited by 17 publications

References 44 publications

Practical calculation method to estimate the absolute boron concentration in tissues using 18F-FBPA PET

Practical calculation method to estimate the absolute boron concentration in tissues using 18F-FBPA PET

Histamine: a potential cytoprotective agent to improve cancer therapy?

The Hamster Model of Sequential Oral Carcinogenesis: An Update

Contact Info

Product

Resources

About