Histamine Release in Man by Propanidid and Thiopentone: Pharmacological Effects and Clinical Consequences

Abstract

ing anaesthesia with both substances led us to undertake this investigation. To demonstrate, however, that the increased concentration of plasma histamine was actually free, pharmacologically active histamine, we studied gastric acid secretion, heart or pulse rate, and peripheral arterial pressure in the subjects of the investigation.

An improved method for the determination of histamine release in man: Its application in studies with propanidid and thiopentone

“…However, release of histamilm from the heart cannot be excluded as a cause of these reactions and this aspect must be separately studied; (3) in persons with abnormalities relating to histamine storage or catabolism, as well as in those with an 'allergic diathesis', release of large amounts of histamine by propanidid or thiopentone, sufficient to evoke strong reactions from the circulatory system cannot be excluded. Such incidents with propanidid are described in another paper (Lorenz et al, 1972a).…”

“…1 : 100) is the reason why only large increases of plasma histamine, as seen in severe incidents (Lorenz et al, 1972a), can dependably be measured by histamine determination in whole blood, and then only when the basophil content remains constant. However, since the histamine increase in whole blood is not entirely free histamine, the determination of this amine in human whole blood as a method for determining histamine release by anesthetics and muscle relaxants (Westgate andvan Bergen, 1962: Lorenz et al, 1969;Doenicke and Lorenz, 1970), is of limited value and should be combined with indirect measures such as gastric secretion, heart or pulse rate and blood pressure.…”

Histamine and peptic ulcer: A prospective study of mucosal histamine concentration in duodenal ulcer patients and in control subjects suffering from various gastrointestinal diseases

“…There are several speculative mechanisms by which free histamine levels might be elevated around the parietal cell: (1) increased plasma histamine concentrations may occur in liver insufficiency and portacaval shunting, but have been demonstrated conclusively only in acute situations such as after drug administration and operations (Lorenz et al, 1972;, (2) histamine may be released from gastric mast cell stores in abnormally large amounts by gastric stimulants, (3) enhanced formation of (induced?) histamine may be elicited by various nervous and humoral factors (for a review see Lorenz and Pfleger, 1968), (4) finally, the inactivation of histamine may be decreased by influences on histamine methyltransferase activity Barth et al, 1975) or on histamine uptake .…”

Histamine release in anaesthesia and surgery. Premedication with H1- and H2-receptor antagonists: Indications, benefits and possible problems

“…Correlation between plasma histamine concentration, pulse rate and blood pressure in 4 cases of pseudo-allergic reactions to propanidid (Epontol). Values from single determinations [19]. = Histamine; --= pulse rate; --[-i-= blood pressure; n.p.…”

“…Mean vatues±SEM from 5 patients. --= Heart rate; .... blood pressure [19] Since our first investigation in 1969 [17] we investigated eight anaesthetic and hypnotic agents in man. Our studies on thiopentone in volunteers were made in 1970 (Fig.…”